Sanat Dixit MD, MBA, FACS

Huntsville, Alabama, United States Contact Info
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"Intelligence and capability are not enough. There must also be the joy of doing…

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Experience & Education

  • Vanderbilt University - Owen Graduate School of Management

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Publications

  • Endovascular thrombectomy for acute ischemic stroke in failed intravenous tissue plasminogen activator versus non-intravenous tissue plasminogen activator patients: revascularization and outcomes stratified by the site of arterial occlusions.

    Stroke

    Intracranial mechanical thrombectomy is a therapeutic option for acute ischemic stroke patients failing intravenous tissue plasminogen activator (IV tPA). We compared patients treated by mechanical embolus removal in cerebral ischemia (MERCI) thrombectomy after failed IV tPA with those treated with thrombectomy alone.

    Other authors
    • Shi ZS, Loh Y, Walker G, Duckwiler GR; MERCI and Multi MERCI Investigators.
    See publication
  • Clinical outcomes in middle cerebral artery trunk occlusions versus secondary division occlusions after mechanical thrombectomy: pooled analysis of the Mechanical Embolus Removal in Cerebral Ischemia (MERCI) and Multi MERCI trials.

    Stroke

    The benefit of endovascular revascularization of patients with acute ischemic stroke with middle cerebral artery (MCA) secondary division (M2) occlusions as compared with MCA trunk (M1) occlusions is not known. In this analysis, we compared revascularization status and clinical outcomes in patients with angiographically confirmed MCA M1 versus isolated M2 occlusions treated with mechanical thrombectomy using the Merci Retriever devices.

    Other authors
    • Zhong-Song Shi, MD; Yince Loh, MD; Gary Walker, PhD; Gary R. Duckwiler, MD; for the MERCI and Multi MERCI
    See publication
  • Hydrogel-coated coils for the treatment of cerebral aneurysms: preliminary results.

    Neurosurgical Focus

    The authors present a retrospective analysis of their initial experience with the recently developed MicroVention HydroCoil to treat patients with cerebral aneurysms. Unlike the bare metal coils initially available for endovascular treatment of aneurysms, HydroCoils have a layer of hydrogel polymer surrounding a platinum metallic core. The hydrogel polymer expands soon after making contact with blood. The expanded hydrogel polymer provides increased volumetric filling compared with bare metal…

    The authors present a retrospective analysis of their initial experience with the recently developed MicroVention HydroCoil to treat patients with cerebral aneurysms. Unlike the bare metal coils initially available for endovascular treatment of aneurysms, HydroCoils have a layer of hydrogel polymer surrounding a platinum metallic core. The hydrogel polymer expands soon after making contact with blood. The expanded hydrogel polymer provides increased volumetric filling compared with bare metal coils and offers a more biocompatible surface, as demonstrated in animal models.

    Other authors
    • Adam S Arthur MD,MPH
    • Stephanie S Wilson RN
    • John D Barr, MD
    See publication
  • Neutralizing antibody against interleukin-6 attenuates posthemorrhagic vasospasm in the rat femoral artery model.

    Neurosurgery

    The degree to which inflammation contributes to the development of posthemorrhagic vasospasm is controversial. In the present study, we investigated the relationship between various inflammatory cytokines (tumor necrosis factor-alpha, interleukin [IL]-1alpha, IL-1beta, and IL-6) and the development of experimental vasospasm. Our results indicate that cytokine-mediated inflammation is active in the setting of posthemorrhagic vasospasm produced by the rat femoral artery model. In particular, the…

    The degree to which inflammation contributes to the development of posthemorrhagic vasospasm is controversial. In the present study, we investigated the relationship between various inflammatory cytokines (tumor necrosis factor-alpha, interleukin [IL]-1alpha, IL-1beta, and IL-6) and the development of experimental vasospasm. Our results indicate that cytokine-mediated inflammation is active in the setting of posthemorrhagic vasospasm produced by the rat femoral artery model. In particular, the profound increase in IL-6 levels after exposure to hemorrhage and the ability of a polyclonal antibody against IL-6 to reduce vasospasm suggest that IL-6 may play a prominent role in the development of vasospasm in this model.

    Other authors
    • George Bowman
    • Robert Bonneau PhD
    • Vernon Chinchilli PhD
    • Kevin S Cockroft MD
    See publication

Languages

  • French

    Elementary proficiency

  • Hindi

    Professional working proficiency

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