“Roseanne is a delight to work with. She is very astute, driven, and has an amazing work ethic. Problem solving is her forte, as a result, she welcomes challenges and takes them on willingly. While she provides insight to others, she also welcomes it.”
San Francisco, California, United States
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I’m excited to announce that Auxilius has raised an additional $10M, led by SignalFire, and with participation from XYZ, Renegade Partners, and CP…
I’m excited to announce that Auxilius has raised an additional $10M, led by SignalFire, and with participation from XYZ, Renegade Partners, and CP…
Liked by Roseanne Wincek
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This is incredible debut work from American Haiku and Thom Glover. Brands are about story telling and this video captures that so brilliantly…
This is incredible debut work from American Haiku and Thom Glover. Brands are about story telling and this video captures that so brilliantly…
Liked by Roseanne Wincek
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We're launching the inaugural edition of Beyond Benchmarks, a deep dive into the metrics and trends observed across the early-stage enterprise cloud…
We're launching the inaugural edition of Beyond Benchmarks, a deep dive into the metrics and trends observed across the early-stage enterprise cloud…
Liked by Roseanne Wincek
Experience & Education
Publications
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Oxygen Isotope Effects on Electron Transfer to O2 Probed Using Chemically Modified Flavins Bound to Glucose Oxidase.
Journal of the American Chemical Society
Apo-glucose oxidase has been reconstituted with flavins modified in the 7 and 8 positions and characterized with regard to the catalytic rate of O2 reduction and oxygen-18 isotope effects on this process. Kinetic studies as a function of driving force indicate a reorganization energy for electron transfer to O2 of λ = 28 kcal mol-1 at optimal pH, which is similar to the value obtained earlier from temperature dependencies of rates (Roth, J. P.; Klinman, J. P. Proc. Natl. Acad. Sci. U.S.A. 2003,…
Apo-glucose oxidase has been reconstituted with flavins modified in the 7 and 8 positions and characterized with regard to the catalytic rate of O2 reduction and oxygen-18 isotope effects on this process. Kinetic studies as a function of driving force indicate a reorganization energy for electron transfer to O2 of λ = 28 kcal mol-1 at optimal pH, which is similar to the value obtained earlier from temperature dependencies of rates (Roth, J. P.; Klinman, J. P. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 62−67). For the various enzyme-bound flavins, competitive oxygen-18 kinetic isotope effects fall within the narrow range of 1.0266(5) to 1.0279(6), apparently because of the dominant contribution of outer-sphere reorganization to the activation barrier; within the context of semiclassical and quantum mechanical electron transfer theories, the magnitude of the isotope effects reveals the importance of nuclear tunneling.
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This week I sat down with Edward Ludlow and Caroline Hyde at Bloomberg to discuss Renegade Partners Fund II and our plans to back founders at durable…
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