“I worked in Renee's organization as an engineer. Renee is a very intelligent and knowledgeable director, and I am very impressed with her insight into engineering practices and methodologies. Moreover, she can be briefed on a software or electrical circuit discrepancy, and with ease understand what is going on. She is also very fair with her group, and fosters an atmosphere of trust in task completion. Her thought processes, system knowledge, and discrepancy resolution are matter of fact, logical, and to the point. Renee ranks up there as one of the best directors I have been associated with in my 20 year engineering career.”
About
Activity
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If you're at ADLM 2024 and curious how a CLSI membership can benefit you and your organization, our Director of Member and User Experience, Katie…
If you're at ADLM 2024 and curious how a CLSI membership can benefit you and your organization, our Director of Member and User Experience, Katie…
Liked by Renee Howell, PhD MLS(ASCP)
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Join Dr. Sharon L. Hillier as she discusses the development of new products for HIV prevention, including those that can be used “on demand” and…
Join Dr. Sharon L. Hillier as she discusses the development of new products for HIV prevention, including those that can be used “on demand” and…
Liked by Renee Howell, PhD MLS(ASCP)
Experience & Education
Licenses & Certifications
Volunteer Experience
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President
Eastchester PTA Council
- 2 years
Education
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Co President
Eastchester Middle School PTA
- 1 year
Children
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Treasurer
Friends of the Tuckahoe Public Library
- 2 years 9 months
Arts and Culture
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PTA President
Walter Johnson High School PTSA
- 1 year 10 months
Children
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Traffic Chair
Luxmanor Citizens Association
- 2 years
Publications
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Qualitative and quantitative detection of SARS-CoV-2 antibodies from dried blood spots
Clinical Biochemistry
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Microfluidic Genotyping by Rapid Serial PCR and High-Speed Melt Analysis
Clinical Chemistry
We demonstrate genotyping accuracy on a novel microfluidic platform with rapid serial PCR
and HSM. We used a microfluidic platform tailored to rapid serial PCR and high-speed melting (HSM) to genotype 4 single nucleotide variants. Two study sites each analyzed 100 samples for F2 (c.*97G?A), F5 (c.1601G?A), and MTHFR (c.665C?T and c.1286A?C) after blinding for genotype and genotype proportions. PCR and HSM were completed in a total of 12.5 min. Melting was performed at 0.5 °C/s. All…We demonstrate genotyping accuracy on a novel microfluidic platform with rapid serial PCR
and HSM. We used a microfluidic platform tailored to rapid serial PCR and high-speed melting (HSM) to genotype 4 single nucleotide variants. Two study sites each analyzed 100 samples for F2 (c.*97G?A), F5 (c.1601G?A), and MTHFR (c.665C?T and c.1286A?C) after blinding for genotype and genotype proportions. PCR and HSM were completed in a total of 12.5 min. Melting was performed at 0.5 °C/s. All samples were correctly genotyped by the instrument.Other authorsSee publication -
Cryopreserved PBMCs and cell-based assays: Preserving fundamental characteristics for immune monitoring and drug development.
Genetic Engineering News 30 (3), 2010
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Establishment of the 1st world health organization international standards for human papillomavirus type 16 DNA and type 18 DNA.
International Journal of Cancer
A World Health Organization collaborative study was conducted to evaluate candidate international standards for human papillomavirus (HPV) Type 16 DNA (NIBSC code 06/202) and HPV Type 18 DNA (NIBSC code 06/206) for use in the amplification and detection steps of nucleic acid-based assays. The freeze-dried candidate international standards were prepared from bulk preparations of cloned plasmid containing full-length HPV-16 or HPV-18 genomic DNA. Nineteen laboratories from 13 countries…
A World Health Organization collaborative study was conducted to evaluate candidate international standards for human papillomavirus (HPV) Type 16 DNA (NIBSC code 06/202) and HPV Type 18 DNA (NIBSC code 06/206) for use in the amplification and detection steps of nucleic acid-based assays. The freeze-dried candidate international standards were prepared from bulk preparations of cloned plasmid containing full-length HPV-16 or HPV-18 genomic DNA. Nineteen laboratories from 13 countries participated in the study using a variety of commercial and in-house quantitative and qualitative assays. The data presented here indicate that, upon freeze-drying, there is no significant loss in potency for the candidate HPV-18 DNA and a slight loss in potency for the candidate HPV-16 DNA; although this is likely not scientifically relevant when assay precision is considered. In general, the individual laboratory mean estimates for each study sample were grouped ±∼2 log10 around the theoretical HPV DNA concentration of the reconstituted ampoule (1 × 107 HPV genome equivalents/mL). The agreement between laboratories is improved when potencies are made relative to the candidate international standards, demonstrating their utility in harmonizing amplification and detection steps of HPV-16 and −18 DNA assays. Degradation studies indicate that the candidate international standards are extremely stable and suitable for long-term use. Based on these findings, the candidate standards were established as the 1st WHO international standards for HPV-16 DNA and HPV-18 DNA, each with a potency of 5 × 106 international units (IU) per ampoule or 1 × 107 IU mL−1 when reconstituted as directed.
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HPV Profile of Women in Belize City, Belize: Correlation with Cervical Cytopathologic Findings
Human Pathology
Cervical carcinoma is the most common cancer among Belizean women; however, data regarding the frequency of human papillomavirus (HPV) genotypes and their association with cervical cancer are nonexistent. We therefore included HPV genotyping as part of a week-long cervical cancer screening campaign conducted in Belize City in 2007. Conventional Papanicolaou smears with Hybrid Capture (HC) 2 HPV testing were performed on 463 women. All HC2-positive samples were genotyped using a developmental…
Cervical carcinoma is the most common cancer among Belizean women; however, data regarding the frequency of human papillomavirus (HPV) genotypes and their association with cervical cancer are nonexistent. We therefore included HPV genotyping as part of a week-long cervical cancer screening campaign conducted in Belize City in 2007. Conventional Papanicolaou smears with Hybrid Capture (HC) 2 HPV testing were performed on 463 women. All HC2-positive samples were genotyped using a developmental GP5+/GP6+ polymerase chain reaction-coupled Luminex assay for 2 low-risk and 18 high-risk HPV types. The prevalence of high-risk HPV was 15.6% in the total population, 10.1% in those with normal cytologic findings, and 93.3% in women with a high-grade squamous intraepithelial lesion. Of patients with HPV infections, 35% had multiple types (5.4% of the total group). Of all women and of women with normal cytologic findings, 5.2% and 2.8%, respectively, had HPV16 or 18. For all women, HPV16, 18, 56, and 52 were present in decreasing order of frequency. HPV11 was present in only one patient, and none had HPV6. HPV16 was found in 47% of high-grade squamous epithelial lesions; however, no case of HSIL had HPV18 or 45. HPV35 and HPV58 were the next most common types in high-grade squamous intraepithelial lesion, each occurring in 20% of cases of high-grade squamous intraepithelial lesion, followed by HPV31 in 13.3%. Although women younger than 25 years old were underrepresented, these data suggest that the HPV profile of this cohort of Belizean women differs somewhat from that in the region. In addition, these data are of importance with regard to the development of HPV vaccines that will be used in less developed countries, where care should be taken not to implement vaccination at the cost of basic screening and diagnostic services.
Other authorsSee publication
Patents
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Thermal Calibration
Issued US 10591364
The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers…
The present invention relates to the use of one or more amplicons as temperature calibrators. In some embodiments, the calibrators may be used to calibrate the temperature of a microfluidic channel in which amplification and/or melt analysis is performed. In some embodiments, the amplicons may be genomic, ultra conserved elements and/or synthetic. The amplicon(s) may have a known or expected melt temperature(s). The calibrators may be added to primers of study or may follow or lead the primers of study in the channel. The amplicon(s) may be amplified and melted, and the temperature(s) at which the amplicon(s) melted may be determined. The measured temperature(s) may be compared to the known temperature(s) at which the amplicon(s) was expected to melt. The difference(s) between the measured and expected temperatures may be used to calibrate/adjust one or more temperature control elements used to control and/or detect the temperature of the channel.
Other inventorsSee patent -
Methods and Systems for Sequential Determination of Genetic Mutations and/or Varients
Issued US 9,840,737
The present invention relates to methods and systems for genome scanning using high resolution melting analysis for identifying mutations and/or variants in genes of interest.
Other inventorsSee patent -
Detection of Neighboring Variants
Issued US 9,447,458
The present invention relates to methods, kits, probes, and systems for distinguishing between nucleotide variants that are close in proximity on a gene. The methods, kits, probes, and systems can include the use of a small amplicon assay in combination with two unlabeled probes in a high resolution thermal melting analysis of a biological sample containing a locus of interest in order to discern between disease-causing and benign variants that are close in proximity on a gene within the…
The present invention relates to methods, kits, probes, and systems for distinguishing between nucleotide variants that are close in proximity on a gene. The methods, kits, probes, and systems can include the use of a small amplicon assay in combination with two unlabeled probes in a high resolution thermal melting analysis of a biological sample containing a locus of interest in order to discern between disease-causing and benign variants that are close in proximity on a gene within the biological sample. The present invention also relates to method of detecting a disease in a patient based on the patient's genotype by determining whether the patient has a disease-causing variant at a locus of interest. The signature melt curves produced by the unlabeled probe tests can be analyzed using HRMA software to distinguish between disease-causing and benign variants that are close in proximity on a gene within the biological sample.
Other inventors -
Organizations
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Clinical Laboratory Standards Institute(CLSI)
Advisor/Member Document Development
-Advisor Expert Panel on Molecular Methods 2019 - 2023 Member of the following document committees: M53-A Criteria for Laboratory Testing and Diagnosis of Human Immunodeficiency Virus Infection (advisor) MM20-A Quality Management for Molecular Genetic Testing (advisor) MM01-A3 Molecular Methods for Clinical Genetics and Oncology Testing (member)
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Joint Committee for Traceability in Laboratory Medicine
Siemens Healthcare Representative
-https://www.jctlm.org/
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American Association for Clinical Chemistry
Past Chair Industry Division
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American Association for Clinical Chemistry
Chair Industry Division
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Women's Information Network at Siemens (WIN@S)
Chair - Tarrytown
-WIN@S mission is to inspire our workforce, advance our workplace, and drive innovation and insight to the marketplace through opportunities for women at Siemens Healthineers.
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Association for Molecular Pathology
Industry Member Advisory group
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Maryland Tech Council
BioAlliance Program Committee
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Great to see Frances making this case!
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PTA is the parent organization at school; its the moms' group; its the parents who volunteer at school and run the booksale. And its a non-profit…
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