About
Articles by Dr. Prasun
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GenAI: Revolutionizing Healthcare and Life Sciences
GenAI: Revolutionizing Healthcare and Life Sciences
By Dr. Prasun Mishra
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Revolutionizing Drug Discovery: Unleashing AI and Generative Modeling for Molecular Innovation
Revolutionizing Drug Discovery: Unleashing AI and Generative Modeling for Molecular Innovation
By Dr. Prasun Mishra
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Navigating the Cutting Edge: Recent Trends in Precision Medicine
Navigating the Cutting Edge: Recent Trends in Precision Medicine
By Dr. Prasun Mishra
Activity
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Did you know that some people have never caught COVID-19? A new study might explain why! 🌟 Research published in the June 2024 issue of Nature…
Did you know that some people have never caught COVID-19? A new study might explain why! 🌟 Research published in the June 2024 issue of Nature…
Liked by Dr. Prasun Mishra
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On this day, July 10, in 1856, a brilliant mind was born—Nikola Tesla. His life is filled with stories that could rival the best novels. I am sharing…
On this day, July 10, in 1856, a brilliant mind was born—Nikola Tesla. His life is filled with stories that could rival the best novels. I am sharing…
Shared by Dr. Prasun Mishra
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👁️ Ever wondered how aging affects our eyesight? 🕵️♂️ Check out this fascinating Hitchcockian video of 64 eyeballs rolling and blinking in…
👁️ Ever wondered how aging affects our eyesight? 🕵️♂️ Check out this fascinating Hitchcockian video of 64 eyeballs rolling and blinking in…
Shared by Dr. Prasun Mishra
Experience & Education
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Precision BioPharma
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Licenses & Certifications
Publications
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MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity
Scientific Reports – Nature
Gill P, Bhattacharyya S, McCullough S, Dweep H, Mishra PJ, Luo C, Letzig L, James L (2017)
Other authors -
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Keratinocyte Induced Differentiation of Mesenchymal Stem Cells into Dermal Myofibroblasts: A Role in EffectiveWound Healing
International Journal of Translational Science
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Receptor tyrosine kinase AXL is upregulated in metformin resistant prostate cancer cells
Oncotarget
Nitu Bansal, Prasun J. Mishra, Mark Stein, Robert S. DiPaola, Joseph R. Bertino
(Keywords: Axl receptor tyrosine kinase, metformin, prostate cancer, Axl, drug resistance, personalized medicine)Other authors -
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A MicroRNA Binding Site SNP Leads to Drug Resistance and Cellular Transformation
Book: Published by Rutgers University. 272 pages
See publicationPrasun J Mishra
(Keywords: drug resistance, single nucleotide polymorphism, 3' UTR, translational
regulation, mRNA stability, personalized medicine, microRNAs, miR-24, cell proliferation, cell cycle, gene regulation, cellular transformation, cell cycle arrest, dihydrofolate reductase, DHFR, methotrexate, antifolate, chemotherapy, polymorphism, 3' UTR, human colorectal cancer tumors, p53) -
A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance.
Proceedings of the National Academy of Sciences of USA. 2007 Aug 14;104(33):13513-8. Epub 2007 Aug 8.
Prasun J. Mishra, Rita Humeniuk, Pravin J. Mishra, Giuseppe S. A. Longo-Sorbello, Debabrata Banerjee, and Joseph R. Bertino
(Keywords: drug resistance, single nucleotide polymorphism, 3' UTR, translational
regulation, mRNA stability, personalized medicine)Other authors -
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A traitor in our midst: mesenchymal stem cells contribute to tumor progression and metastasis.
Future Oncology 2008 Dec;4(6):745-9. doi: 10.2217/14796694.4.6.745.
Prasun J. Mishra and Glenn Merlino
(Keywords: Tumor microenvironment, SDF-1, myofibroblast, cancer fibrosis, migration, differentiation, personalized medicine)Other authors -
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Aplidin synergizes with cytosine arabinoside: functional relevance of mitochondria in Aplidin-induced cytotoxicity.
Leukemia. 2007 Dec;21(12):2399-405.
Humeniuk R, Menon LG, Prasun J Mishra, Saydam G, Longo-Sorbello GS, Elisseyeff Y, Lewis LD, Aracil M, Jimeno J, Bertino JR, Banerjee D
(Keywords: Aplidine, araC, drug combination, personalized medicine, mitochondria, hematological malignancies)Other authors -
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Bone marrow skeletal stem/progenitor cell defects in dyskeratosis congenita and telomere biology disorders
Blood. 2015 Jan 29;125(5):793-802.
Arun Balakumaran, Prasun J. Mishra, Edyta Pawelczyk, Sayuri Yoshizawa, Brian J Sworder, Natasha Cherman, Sergei A. Kuznetsov, Paolo Bianco, Neelam Giri, Sharon A. Savage, Glenn Merlino, Bogdan Dumitriu, Cynthia E. Dunbar, Neal S. Young, Blanche P. Alter, Pamela G. Robey
(Keywords: Dyskeratosis congenita and telomere biology disorders, bone marrow skeletal stem/progenitor cell, BMSCs, MSCs, TBDs, hematopoiesis, TERC, fibrosis, genomics, personalized medicine).Other authors -
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Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells.
Cancer Research. 2008 Jun 1;68(11):4331-9.
Pravin J Mishra*, Prasun J Mishra* (* jointly first authored), Rita Humeniuk, Daniel J Medina, Gabriela Alexe, Jill P Mesirov, Sridhar Ganesan, John W Glod, Debabrata Banerjee
(Keywords: Tumor microenvironment, SDF-1, myofibroblast, cancer fibrosis, migration, differentiation, personalized medicine)Other authors -
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Cell-free derivatives from mesenchymal stem cells are effective in wound therapy.
WJ Stem Cells 05/2012; 4(5):35-43.
Pravin J Mishra, Prasun J Mishra, Debabrata Banerjee
(Keywords: Stem cell derivatives, Keratinocyte, Mesenchymal stem cell, Cytokine secretion, Wound healing, SDF1, ENA78, fibrosis, animal models, personalized medicine)Other authors -
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Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Molecular Cancer Therapeutics 05/2009; 8(5):1037-44.
Humeniuk R, Menon LG, Prasun J Mishra, Gorlick R, Sowers R, Rode W, Pizzorno G, Cheng YC, Kemeny N, Bertino JR, Banerjee D
(Keywords: UMP Kinase, fluoropyrimidine, cancer, DNA methylation inhibitor, antineoplastic agent, diagnosis, drug resistance, promoter methylation, chemotherapeutic agent, personalized medicine)Other authors -
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Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.
Oncogene 04/2011; 30(15):1850-1850.
Prasun J Mishra, L. Ha, J. Rieker, E. V. Sviderskaya, D. C. Bennett, M. D. Oberst, K. Kelly, G. Merlino
(Keywords: Anchorage-independent growth, BRaf; cRaf, melanoma, NRas, PI3K, RalGEF, personalized medicine)Other authors -
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Effect of Single and Recurrent Gamma Irradiation on in vitro Cultures
IJF Science 12/2007; 7(1):47-57.
Prasun J. Mishra, T. R. Ganapathi, P. Suprasanna, V. A. Bapat
(Keywords: Phenotypic screening, mutations, gamma rays, recurrent irradiation, induced mutagenesis, genetic engineering)Other authors -
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Epigenetic reversal of acquired resistance to 5-fluorouracil treatment.
Molecular Cancer Therapeutics 05/2009; 8(5):1045-54.
Humeniuk R, Prasun J Mishra, Bertino JR, Banerjee D
(Keywords: UMP Kinase, fluoropyrimidine resistance, cancer, DNA methylation inhibitor, antineoplastic agent, promoter methylation, diagnosis, drug resistance to treatment, chemotherapeutic agent, personalized medicine)Other authors -
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Heparin and Suramin Alter Plitidepsin Uptake Via Inhibition of GPCR Coupled Signaling
Journal of Chemotherapy (Florence, Italy) 10/2009; 21(5):550-557.
G S A Longo-Sorbello, H Gao, Prasun J Mishra, B Kamen, A Soto, J Jimeno, M Aracil, M F Paz de Paz, J R Bertino, D Banerjee
(Keywords: Plitidepsin, Aplidium albicans, Aplidine, personalized medicine, multiple myeloma, renal cell carcinoma, melanoma, neuroblastoma, leukemia, lymphoma, suramin, heparin)Other authors -
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Human salivary alpha-amylase Trp58 situated at subsite -2 is critical for enzyme activity.
Eur J Biochemistry 2004 Jun;271(12):2517-29.
Ramasubbu N, Ragunath C, Mishra PJ, Thomas LM, Gyémánt G, Kandra L
(Keywords: salivary a-amylase, site-directed mutagenesis, subsite engineering, personalized enzymology, oligosaccharide hydrolysis, crystal structure)Other authors -
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Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
Journal of Biological Chemistry 07/2005; 280(24):22721-31.
Skacel N, Menon LG, Prasun J Mishra, Peters R, Banerjee D, Bertino JR, Abali EE
(Keywords: DHFR, dihydrofolate reductase; MTX, methotrexate; NADPH, personalized medicine, site directed mutagenesis, personalized enzymology, drug resistance, chemotherapy)Other authors -
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Improved Antitumoral Treatments
Patent: US 2010/0240595
Prasun J Mishra, along with Mishra Pravin J and Longo GSA, Jimeno J, Aracil M, Poplin E, Bertino JR and Banerjee D, inventors
(Keywords: Methods for the treatment of disorders, cancer, Aplidine, Gemcitabine, fibrosis, diagnosis, drug resistance, chemotherapy, personalized medicine)Other authors -
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Induction of Protein Downstream of Internal Ribosomal Entry Site (IRES) by antifolates treatment
Patent Provisional: 2010/5418
Prasun J Mishra, along with Banerjee D, Bertino JR and Mishra Pravin J, inventors
(Keywords: Bicistronic vectors, dihydrofolate reductase, DHFR, personalized medicine, methotrexate, fusion protein, rapamycin, cap dependent, cap independent translation)Other authors -
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Mesenchymal stem cells: flip side of the coin.
Cancer Research 04/2009; 69(7):3240-3240.
PJ Mishra, Prasun J Mishra, JW Glod, D Banerjee
(Keywords: Tumor microenvironment, SDF-1, myofibroblast, cancer fibrosis, migration, differentiation, personalized medicine)Other authors -
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MicroRNA Polymorphisms
Encyclopedia of Life Sciences (eLS) 04/2013; 15 APR(2013):1-15.
Prasun J Mishra, Rita Humeniuk
(Keywords: miRNAs, MOA, miR-polymorphisms, miRNA polymorphism, drug resistance, drug response, disease progression, diagnosis, personalized medicine)Other authors -
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MicroRNA polymorphisms: a giant leap towards personalized medicine
Personalized Medicine 03/2009; 6(2):119-125.
See publicationPrasun J Mishra
(Keywords: Diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine) -
MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.
Pharmacogenomics. 2009 Mar;10(3):399-416.
Prasun J Mishra and Joseph R Bertino
(Keywords: Classification, diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine)Other authors -
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MicroRNA reexpression as differentiation therapy in cancer.
The Journal of Clinical Investigation 09/2009; 119(8):2119-23.
Prasun J. Mishra and Glenn Merlino
(Keywords: miRNAs, miR-1, miR-206, differentiated rhabdomyosarcoma, RMS, personalized medicine, skeletal muscle, myogenic differentiation, differentiation therapy, oncogenes, tumor development, fibrosis)Other authors -
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MicroRNAs as promising biomarkers in cancer diagnostics.
BMC Biomark Research 2014 Oct 22;2:19.
See publicationPrasun J Mishra
(Keywords: Biomarker, circulating microRNAs, diagnostics, miRNA, miRNA polymorphisms, microvesicles, exosomes, pharmacogenomics, precision medicine, prognosis, variants, personalized medicine) -
MiR-24 tumor suppressor activity is regulated independent of p53 and through a target site polymorphism.
PLoS One. 2009 Dec 24;4(12):e8445.
Prasun J. Mishra, Bo Song, Pravin J. Mishra, Yuan Wang, Rita Humeniuk, Debabrata Banerjee, Glenn Merlino, Jingfang Ju, Joseph R. Bertino
(Keywords: MicroRNAs, miRNAs, miR-24, personalized medicine, cell proliferation, cell cycle, gene regulation, cellular transformation, G2/S cell cycle arrest, dihydrofolate reductase, DHFR, methotrexate, antifolate, chemotherapy, polymorphism, 3' UTR, human colorectal cancer tumors, p53-independent cell cycle inhibitory miRNA)Other authors -
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MiRSNPs or MiR-polymorphisms, new players in microRNA mediated regulation of the cell: Introducing microRNA pharmacogenomics.
Cell Cycle. 2008 Apr 1;7(7):853-8.
Prasun J. Mishra, Pravin J. Mishra, Debabrata Banerjee and Joseph R. Bertino
(Keywords: Diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine)Other authors -
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Modulation of Drug Sensitivity
Patent: US20100151004
Prasun J Mishra, along with Banerjee D, Bertino JR, Humeniuk R, inventors
(Keywords: Methods for the treatment of disorders, cancer, DNA methylation inhibitor, antineoplastic agent, diagnosis, drug resistance to treatment, chemotherapeutic agent, personalized medicine)Other authors -
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Molecular profile of clonal strains of human skeletal stem/progenitor cells with different potencies
Stem Cell Research 02/2015; 9.
Brian J. Sworder*, Sayuri Yoshizawa*, Prasun J. Mishra* (* jointly first authored), Natasha Cherman, Sergei A. Kuznetsov, Glenn Merlino, Arun Balakumaran, Pamela G. Robey
(Keywords: Single colony-derived cells, human bone marrow stromal cells, differentiation, gene expression, fibrosis, multipotent, non-multipotent strains, personalized medicine)Other authors -
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Molecular targets for epigenetic therapy of cancer.
Current Pharmaceutical Biotechnology 03/2009; 10(2):161-5.
Humeniuk R, Prasun J Mishra, Bertino JR, Banerjee D
(Keywords: Drug resistance, epigenetic therapy, chromatin modifications, DNA methylation, personalized medicine, combination chemotherapy)Other authors -
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Non-coding RNAs as clinical biomarkers for cancer diagnosis and prognosis
Expert Review of Molecular Diagnostics 11/2014; 14(8):917-9.
See publicationPrasun J Mishra
(Keywords: Biomarker, circulating microRNAs, diagnostics, miRNA, miRNA polymorphisms, microvesicles, exosomes, pharmacogenomics, precision medicine, prognosis, variants, personalized medicine) -
Pharmacogenomics of microRNA: a miRSNP towards individualized therapy.
Pharmacogenomics 01/2008; 8(12):1625-7.
Joseph R Bertino, Debabrata Banerjee, Prasun J Mishra
(Keywords: Diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine)Other authors -
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Probing the role of a mobile loop in substrate binding and enzyme activity of human salivary amylase.
Journal of Molecular Biology 01/2003; 325(5):1061-76.
Ramasubbu N, Ragunath C, Prasun J Mishra
(Keywords: salivary amylase, crystal structure, complex, mobile loop, starch hydrolysis, enzyme, oligosaccharides, HPLC separation, enzyme kinetics, personalized enzymology, catalysis, glucose formation, site-directed mutagenesis)Other authors -
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Structure-function relationships in human salivary alpha-amylase: role of aromatic residues
Biologia 01/2005; 60:47-56.
Ramasubbu N, Ragunath C, Sundar K, Prasun J Mishra, Gyémánt G, Kandra L
(Keywords: Salivary α-amylase, site-directed mutagenesis, subsite engineering, personalized enzymology, oligosaccharide hydrolysis,crystal structure)Other authors -
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The mechanism of salivary amylase hydrolysis: role of residues at subsite S2'.
Biochem Biophys Res Commun. 2002 Mar 29;292(2):468-73.
Prasun J Mishra, Ragunath C, Ramasubbu N
(Keywords: amylase; enzyme, oligosaccharides, HPLC separation, enzyme kinetics, personalized enzymology, catalysis, glucose formation, site-directed mutagenesis)Other authors -
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The miRNA-drug resistance connection: a new era of personalized medicine using noncoding RNA begins.
Pharmacogenomics 09/2012; 13(12):1321-4.
See publicationPrasun J Mishra
(Keywords: Diagnosis, disease, drug resistance, epidemiology, genetic variation, genomic medicine, individualized medicine, microRNA, miRNA, miRSNP, mutations, ncRNA, noncoding RNA, personalized medicine, pharmacogenomics, polymorphisms, prognosis) -
The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy.
Expert Opinion on Biological Therapy 08/2007; 7(7):965-73.
See publicationPicinich SC, Mishra PJ, Prasun J Mishra, Glod J, Banerjee D
(Keywords: diagnosis, disease, drug resistance, epidemiology, epigenetics, microRNA, miRSNP, mutations, pharmacogenomics, miR polymorphisms, prognosis, SNP, personalized medicine, individualized medicine) -
Translational modulation of proteins expressed from bicistronic vectors.
Molecular Imaging 12/2009; 8(6):305-18.
Prasun J. Mishra, Lata G. Menon, Pravin J. Mishra, Philipp Mayer-Kuckuk, Joseph R. Bertino, and Debabrata Banerjee
(Keywords: Bicistronic vectors, dihydrofolate reductase, DHFR, personalized medicine, methotrexate, fusion protein, rapamycin, cap dependent, cap independent translation)Other authors -
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Use of Stem Cells for Wound Healing and Anti-Cancer Therapy
Patent: 20110020291, Year: 01/2011
Prasun J Mishra, along with Banerjee D, Mishra Pravin J, Bertino JR, Humeniuk R, Glod JW, inventors
(Keywords: Cell therapy, compositions, MOA, stem cell delivery, fibrosis, cell free concentrate, accelerated wound healing, personalized medicine, normal and chronic wounds, scar tissue)Other authors -
More activity by Dr. Prasun
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Did you know that some people have never caught COVID-19? A new study might explain why! 🌟 Research published in the June 2024 issue of Nature…
Did you know that some people have never caught COVID-19? A new study might explain why! 🌟 Research published in the June 2024 issue of Nature…
Shared by Dr. Prasun Mishra
-
"Arise, awake, and stop not till the goal is reached." - Swami Vivekananda On July 4th, as we celebrate the spirit of freedom and independence in…
"Arise, awake, and stop not till the goal is reached." - Swami Vivekananda On July 4th, as we celebrate the spirit of freedom and independence in…
Liked by Dr. Prasun Mishra
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"Arise, awake, and stop not till the goal is reached." - Swami Vivekananda On July 4th, as we celebrate the spirit of freedom and independence in…
"Arise, awake, and stop not till the goal is reached." - Swami Vivekananda On July 4th, as we celebrate the spirit of freedom and independence in…
Shared by Dr. Prasun Mishra
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The essence of America – that which really unites us – is not ethnicity, or nationality, or religion. It is an idea – and what an idea it is: that…
The essence of America – that which really unites us – is not ethnicity, or nationality, or religion. It is an idea – and what an idea it is: that…
Liked by Dr. Prasun Mishra
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The essence of America – that which really unites us – is not ethnicity, or nationality, or religion. It is an idea – and what an idea it is: that…
The essence of America – that which really unites us – is not ethnicity, or nationality, or religion. It is an idea – and what an idea it is: that…
Shared by Dr. Prasun Mishra
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