Boston, Massachusetts, United States
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Thanks to insightful conversations today on 🎙 “BARDA & Ban2.0 Program” with Mary Larkin and Manbir Singh from the BARDA Accelerator Network 🎙…
Thanks to insightful conversations today on 🎙 “BARDA & Ban2.0 Program” with Mary Larkin and Manbir Singh from the BARDA Accelerator Network 🎙…
Liked by Laura Stevens
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We are ready – Discover BioLabs @ BIO 2024! 🌍 Join us at the BioLabs booth #1110 to learn how our global network fosters innovation around the…
We are ready – Discover BioLabs @ BIO 2024! 🌍 Join us at the BioLabs booth #1110 to learn how our global network fosters innovation around the…
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Experience & Education
Publications
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Self-Neutralizing Oligonucleotides with enhanced cellular uptake
Organic and Biomolecular Chemistry
There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle. We addressed this problem by developing a new approach for ON charge neutralization in which multiple branched charge-neutralizing sleeves (BCNSs) are attached to the internucleoside phosphates of ON by phosphotriester bonds. The BCNSs are terminated with positively charged amino groups, and are optimized to form ion pairs with the neighboring…
There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle. We addressed this problem by developing a new approach for ON charge neutralization in which multiple branched charge-neutralizing sleeves (BCNSs) are attached to the internucleoside phosphates of ON by phosphotriester bonds. The BCNSs are terminated with positively charged amino groups, and are optimized to form ion pairs with the neighboring phosphate groups. The new modified ONs can be prepared by standard automated phosphoramidite chemistry in good yield and purity. They possess good solubility and hybridization properties, are not involved in non-standard intramolecular aggregation, have low cytotoxicity, adequate chemical stability, improved serum stability, and above all, display significantly enhanced cellular uptake. Thus, the new ON derivatives exhibit properties that make them promising candidates for the development of novel therapeutics or research tools for modulation of the expression of target genes.
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Redefining the Life Science Buying Cycle: A novel paradigm enabling life science tools companies to communicate with their entire target market in order to build a strong brand.
BioBM Consulting
Life science marketing is traditionally geared towards pitching solutions or paired feature-benefit combinations to scientists or other relevant individuals. While this largely makes sense on a superficial level, it relies on the “traditional” definition of the buying cycle, in which all individuals are presumed to have an identified need. While useful for driving short-term demand, this approach to marketing, and indeed this paradigm of the buying cycle, does not effectively address large…
Life science marketing is traditionally geared towards pitching solutions or paired feature-benefit combinations to scientists or other relevant individuals. While this largely makes sense on a superficial level, it relies on the “traditional” definition of the buying cycle, in which all individuals are presumed to have an identified need. While useful for driving short-term demand, this approach to marketing, and indeed this paradigm of the buying cycle, does not effectively address large portions of a company’s target market. In this paper, we present an amended view of the life science buying cycle and advise companies on how to amend their marketing approach in order to more effectively target a larger quantity of their target market.
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A Secreted MMP is Required for Reepithelialization during Wound Healing
Molecular Biology of the Cell
Matrix metalloproteinases (MMPs) are extracellular proteases highly expressed at wound sites. However, the precise function of MMPs during reepithelialization in vivo has been elusive in mammalian models because of the high level of redundancy among the 24 mammalian MMPs. For this reason we used Drosophila melanogaster, whose genome encodes only two MMPs-one secreted type (Mmp1) and one membrane-anchored type (Mmp2)-to study the function and regulation of the secreted class of MMPs in vivo. In…
Matrix metalloproteinases (MMPs) are extracellular proteases highly expressed at wound sites. However, the precise function of MMPs during reepithelialization in vivo has been elusive in mammalian models because of the high level of redundancy among the 24 mammalian MMPs. For this reason we used Drosophila melanogaster, whose genome encodes only two MMPs-one secreted type (Mmp1) and one membrane-anchored type (Mmp2)-to study the function and regulation of the secreted class of MMPs in vivo. In the absence of redundancy, we found that the Drosophila secreted MMP, Mmp1, is required in the epidermis to facilitate reepithelialization by remodeling the basement membrane, promoting cell elongation and actin cytoskeletal reorganization, and activating extracellular signal-regulated kinase signaling. In addition, we report that the jun N-terminal kinase (JNK) pathway upregulates Mmp1 expression after wounding, but that Mmp1 is expressed independent of the JNK pathway in unwounded epidermis. When the JNK pathway is ectopically activated to overexpress Mmp1, the rate of healing is accelerated in an Mmp1-dependent manner. A primary function of Mmp1, under the control of the JNK pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.
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More activity by Laura
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Lots of exciting innovation in both human health and sustainability coming from this year's cohort of Nucleate San Diego startups. Grateful to have…
Lots of exciting innovation in both human health and sustainability coming from this year's cohort of Nucleate San Diego startups. Grateful to have…
Liked by Laura Stevens
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Today is Day 3 of BIO2024 in San Diego, and we are excited about another day filled with great connections, fun, and innovation. ✨ If you haven't…
Today is Day 3 of BIO2024 in San Diego, and we are excited about another day filled with great connections, fun, and innovation. ✨ If you haven't…
Liked by Laura Stevens
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We are excited to unveil the first two hubs for the next generation of the BARDA Accelerator Network (BAN)! The launch of the two hubs marks a…
We are excited to unveil the first two hubs for the next generation of the BARDA Accelerator Network (BAN)! The launch of the two hubs marks a…
Liked by Laura Stevens
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BioLabs at The Lundquist Institute is thrilled to announce ZEISS Microscopy as a new #sponsor 🎉🎉 Our residents were excited to explore their…
BioLabs at The Lundquist Institute is thrilled to announce ZEISS Microscopy as a new #sponsor 🎉🎉 Our residents were excited to explore their…
Liked by Laura Stevens
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Europe is calling ... Are you a startup seeking additional lab space outside the US? Do you have plans to expand your R&D activities to Germany or…
Europe is calling ... Are you a startup seeking additional lab space outside the US? Do you have plans to expand your R&D activities to Germany or…
Liked by Laura Stevens
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After some much needed rest the BioLabs team is still reeling as we reflect on what a great event #biolabsinvestorday turned out to be. We heard some…
After some much needed rest the BioLabs team is still reeling as we reflect on what a great event #biolabsinvestorday turned out to be. We heard some…
Liked by Laura Stevens
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And the event numbers are in! The tricky part will be counting the follow-on conversations between investors + startups that came out of the event —…
And the event numbers are in! The tricky part will be counting the follow-on conversations between investors + startups that came out of the event —…
Liked by Laura Stevens
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Off she goes! All the rigorous potency, functional, and safety screens we put this ASO thru... its incredible to think of all the hurdles it had to…
Off she goes! All the rigorous potency, functional, and safety screens we put this ASO thru... its incredible to think of all the hurdles it had to…
Liked by Laura Stevens
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🎉 Anais Ralimbimanana rejoint l’équipe de #Spartners by Servier & BioLabs en tant que Operations, Office & Event Associate ! 👏 L’équipe de Saclay…
🎉 Anais Ralimbimanana rejoint l’équipe de #Spartners by Servier & BioLabs en tant que Operations, Office & Event Associate ! 👏 L’équipe de Saclay…
Liked by Laura Stevens
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#Chicago can you feel that change in the air? It's the feeling of momentum, new space and support for #innovation in #Lifescience! I'm beyond…
#Chicago can you feel that change in the air? It's the feeling of momentum, new space and support for #innovation in #Lifescience! I'm beyond…
Liked by Laura Stevens
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Excited to be supporting the inaugural unDavos Social Venture Day at #unDavos this week! unDavos Social Venture Day 2023 will bring together thought…
Excited to be supporting the inaugural unDavos Social Venture Day at #unDavos this week! unDavos Social Venture Day 2023 will bring together thought…
Liked by Laura Stevens
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