Laura Lasiter

Washington DC-Baltimore Area Contact Info
831 followers 500+ connections

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Experience & Education

  • AstraZeneca

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Publications

  • Metabolic regulation of Oocyte cell death through PP-1-mediated dephosphorylation of CaMKII

    Journal of Biological Chemistry

    Francis McCoy*, Rashid Darbandi*, Si-Ing Chen*, Laura Eckard, Keela Dodd, Kelly Jones, Anthony J. Baucum II, Jennifer Gibbons, Sue-Hwa Lin, Roger J. Colbran, and Leta K. Nutt.

    The abnormal metabolism of the Xenopus laevis egg provides a cell survival signal. We previously found that increased carbon flux from glucose-6-phosphate through the pentose phosphate pathway in egg extracts maintains NADPH levels and CaMKII activity to phosphorylate caspase-2 and suppress cell-death pathways…

    Francis McCoy*, Rashid Darbandi*, Si-Ing Chen*, Laura Eckard, Keela Dodd, Kelly Jones, Anthony J. Baucum II, Jennifer Gibbons, Sue-Hwa Lin, Roger J. Colbran, and Leta K. Nutt.

    The abnormal metabolism of the Xenopus laevis egg provides a cell survival signal. We previously found that increased carbon flux from glucose-6-phosphate through the pentose phosphate pathway in egg extracts maintains NADPH levels and CaMKII activity to phosphorylate caspase-2 and suppress cell-death pathways. Here we show that the addition of glucose-6-phosphate (G6P) to oocyte extracts inhibits the dephosphorylation/inactivation of CaMKII bound to caspase-2 by protein phosphatase 1 (PP1). Thus, G6P sustains the phosphorylation of caspase-2 by CaMKII at Ser-135, preventing the induction of caspase-2 mediated apoptotic pathways. These findings expand our understanding of oocyte biology and clarify mechanisms underlying the metabolic regulation of CaMKII and apoptosis. Furthermore, these findings suggest novel approaches to disrupt the suppressive effects of the abnormal metabolism on cell death pathways.
    *These authors contributed equally

    See publication

Organizations

  • Life Science Tennessee Academic Alliance

    Executive Director for the Mid-South Academic Alliance

    - Present

  • American Society for Biomedical and Molecular Biology

    Hill Day Participant

    -

  • Biology Graduate Student Association

    Co-founder/treasurer

    -

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