Kristen Slawinski, PhD
Orange County, California, United States
16K followers
500+ connections
About
Articles by Kristen
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For Marketers: A Guide for Building Trust and Expanding Reach by Partnering with Patient Advocacy Groups
For Marketers: A Guide for Building Trust and Expanding Reach by Partnering with Patient Advocacy Groups
By Kristen Slawinski, PhD
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Finding the Career to Maximize Your Happiness
Finding the Career to Maximize Your Happiness
By Kristen Slawinski, PhD
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JPM is my Burning Man, and Here’s Why
JPM is my Burning Man, and Here’s Why
By Kristen Slawinski, PhD
Contributions
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Here's how you can network and build connections in the research field.
Expand your idea of 'publishing' beyond academic journals. The world is listening through social media and even 150 character tweets are considered newsworthy. Scientists respect knowledge and understanding, so you must demonstrate those qualities publicly. Creating and posting informatory summaries of research within your field will undoubtedly get you noticed by the research community. Think of them like mini-reviews with your own commentary. Be your own publisher! Don't wait for Nature 😉
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What do you do if the content produced by your team is not meeting quality standards?
Your team may never be able to create content at a high standard because they may not have a talent for it. Writing skills can be developed, but a natural talent for communicating/storytelling is also needed. If this is the case, don't rely on your team for the content. Outsource it! Hire professionals that have the skills and talent. (like us!)
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What do you do if you need to create e-books for your content marketing campaign?
eBooks are quite an undertaking. It's key to delegate the work, but it may be very difficult getting people to prioritize the writing within your organization. Consider outsourcing with a professional writing organization, like mine! We write eBook chapters all the time and get them done within a couple of weeks. If you hire outside writers, you can have an entire eBook finished within a month (or less)!
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What do you do if you're a content marketer facing tight deadlines without compromising quality?
Hire us! Outsource the writing and editing. Don't rely on your internal marcom team to get things done on time. Professional writers will get the job done faster and can become a trusted part of your team.
Activity
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Calling All Bioprocessing Enthusiasts: Help Revolutionize Cancer Treatment with CAR-T! Are you passionate about bringing cutting-edge therapies to…
Calling All Bioprocessing Enthusiasts: Help Revolutionize Cancer Treatment with CAR-T! Are you passionate about bringing cutting-edge therapies to…
Liked by Kristen Slawinski, PhD
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Ha just yesterday made a post about how the IPO banks protect the issue price. Note Tempus AI stock right now - Tempus was about to "break issue"…
Ha just yesterday made a post about how the IPO banks protect the issue price. Note Tempus AI stock right now - Tempus was about to "break issue"…
Liked by Kristen Slawinski, PhD
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GRAIL loses 94% value.... anybody else see this coming?
GRAIL loses 94% value.... anybody else see this coming?
Shared by Kristen Slawinski, PhD
Experience & Education
Publications
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aMAGEing new players enter the RING to promote ubiquitylation
Molecular Cell
The MAGE proteins are best known as curious tumor-specific antigens. However, Doyle et al. (2010) reveal that MAGE proteins interact with RING proteins to promote ubiquitylation which provides important new insights into the physiological and pathological functions of this enigmatic family of proteins.
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Heterochromatin silencing of p53 target genes by a small viral protein
Nature
The transcription factor p53 (also known as TP53) guards against tumour and virus replication and is inactivated in almost all cancers. p53-activated transcription of target genes is thought to be synonymous with the stabilization of p53 in response to oncogenes and DNA damage. During adenovirus replication, the degradation of p53 by E1B-55k is considered essential for p53 inactivation, and is the basis for p53-selective viral cancer therapies. Here we reveal a dominant epigenetic mechanism…
The transcription factor p53 (also known as TP53) guards against tumour and virus replication and is inactivated in almost all cancers. p53-activated transcription of target genes is thought to be synonymous with the stabilization of p53 in response to oncogenes and DNA damage. During adenovirus replication, the degradation of p53 by E1B-55k is considered essential for p53 inactivation, and is the basis for p53-selective viral cancer therapies. Here we reveal a dominant epigenetic mechanism that silences p53-activated transcription, irrespective of p53 phosphorylation and stabilization. We show that another adenoviral protein, E4-ORF3, inactivates p53 independently of E1B-55k by forming a nuclear structure that induces de novo H3K9me3 heterochromatin formation at p53 target promoters, preventing p53-DNA binding. This suppressive nuclear web is highly selective in silencing p53 promoters and operates in the backdrop of global transcriptional changes that drive oncogenic replication. These findings are important for understanding how high levels of wild-type p53 might also be inactivated in cancer as well as the mechanisms that induce aberrant epigenetic silencing of tumour-suppressor loci. Our study changes the longstanding definition of how p53 is inactivated in adenovirus infection and provides key insights that could enable the development of true p53-selective oncolytic viral therapies.
Other authorsSee publication -
The TRIM family is targeted by multiple oligomeric DNA virus proteins known to disrupt PML
Publication in progress
Confidential until published
More activity by Kristen
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Revise and rewrite - Revising is part of writing. Few writers are so expert that they can produce what they are after on the first try. ✂ Quite…
Revise and rewrite - Revising is part of writing. Few writers are so expert that they can produce what they are after on the first try. ✂ Quite…
Shared by Kristen Slawinski, PhD
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