Hanson Chang

A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed… Show more

A peptide synthesis instrument can be used for small scale peptide synthesis. The instrument can include several unique features, including a compression style reaction vessel permitting quick setup of the reaction vessel, a double reaction vessel system permitting efficient mixing without loss of solvent or solvent-to-resin contact, gravity-fed heated reservoirs establishing a fixed volume for delivery to the reaction vessel, fume-free solvent addition permitting solvent addition to fixed bottles, and an improved amino acid manifold assembly which reduces the number of components and increases the ease of use of the instrument. Each of these features improve upon the current state of the art in solid phase automated peptide synthesizers. Show less

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.

A medical device configured to be secured to an individual may include a housing containing one or more electrical components, and one or more leads electrically connected to the housing. Each lead may include an insulating jacket that surrounds a central core including one or more conductors, and at least one pressure-resisting member integrally formed with one or both of the insulating jacket or the central core. The pressure-resisting member is configured to resist one or more forces exerted… Show more

A medical device configured to be secured to an individual may include a housing containing one or more electrical components, and one or more leads electrically connected to the housing. Each lead may include an insulating jacket that surrounds a central core including one or more conductors, and at least one pressure-resisting member integrally formed with one or both of the insulating jacket or the central core. The pressure-resisting member is configured to resist one or more forces exerted into the central core. For example, the pressure-resisting member may include one or more of a suture-anchoring member or a lead-strengthening member. Show less

Implementations of the present disclosure involve an internal pulse generator for administering electrotherapy via an implantable medical lead having a lead connector end on a proximal end of the lead. In addition, implementations involve testing of the medical lead at the proximal lead connector end to ensure proper placement of the lead, and an interface device for facilitating the connection of the proximal lead connector end to a testing device. The interface device may provide for one or… Show more

Implementations of the present disclosure involve an internal pulse generator for administering electrotherapy via an implantable medical lead having a lead connector end on a proximal end of the lead. In addition, implementations involve testing of the medical lead at the proximal lead connector end to ensure proper placement of the lead, and an interface device for facilitating the connection of the proximal lead connector end to a testing device. The interface device may provide for one or more electrical connection points disposed on a connector sleeve. The connection points provide electrical communication between the lead connector end of the lead and one or more leads of a testing device in such a manner as to minimize potential damage to the lead connector end. Show less