Charlotte, North Carolina, United States
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Articles by David
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Speaking from Experience: The Many Benefits of Informational Interviews
Speaking from Experience: The Many Benefits of Informational Interviews
By David Prim, PhD
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Commentary on 'Why "Alternative" Careers in STEM Aren’t "Alternative"'
Commentary on 'Why "Alternative" Careers in STEM Aren’t "Alternative"'
By David Prim, PhD
Activity
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Moore School alumnus Millie Orlando (‘21 finance and international business, ’22 double-degree MIB) recently had the incredible opportunity to take…
Moore School alumnus Millie Orlando (‘21 finance and international business, ’22 double-degree MIB) recently had the incredible opportunity to take…
Liked by David Prim, PhD
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Enjoyed visiting with WSJ's Brian Gormley around the uptick in VC healthtech investment, dominated by AI technologies. That said, unlike the biotech…
Enjoyed visiting with WSJ's Brian Gormley around the uptick in VC healthtech investment, dominated by AI technologies. That said, unlike the biotech…
Liked by David Prim, PhD
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We’re proud to play a role in the growth of @Endogenex – who this week announced an $88M Series C round! Endogenex is pioneering new approaches to…
We’re proud to play a role in the growth of @Endogenex – who this week announced an $88M Series C round! Endogenex is pioneering new approaches to…
Liked by David Prim, PhD
Experience & Education
Licenses & Certifications
Volunteer Experience
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Vice President
CL-SCASA
- 1 year 10 months
Arts and Culture
Vice President of the Central League, a 501(c)(3) nonprofit under the umbrella of the South Carolina Amateur Soccer Association and United States Soccer Federation. In my role as Vice President, I act as standing Chair of the Discipline Committee, where it is my responsibility to levy fines and suspensions for serious disciplinary infractions.
www.columbiascsoccer.org -
Goalkeeper Coach - Boys Soccer
River Bluff High School
- 2 years 7 months
Children
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Construction
Sea Island Habitat for Humanity
Poverty Alleviation
Helped construct houses for underprivileged citizens
Publications
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Comparative mechanics of diverse mammalian carotid arteries
PLOS One
The prevalence of diverse animal models as surrogates for human vascular pathologies necessitate a comprehensive understanding of the differences that exist between species. Comparative passive mechanics are presented here for the common carotid arteries taken from bovine, porcine, ovine, leporine, murine-rat, and murine-mouse specimens. Data is generated using a scalable biaxial mechanical testing device following consistent circumferential (pressure-diameter) and axial (force-length) testing…
The prevalence of diverse animal models as surrogates for human vascular pathologies necessitate a comprehensive understanding of the differences that exist between species. Comparative passive mechanics are presented here for the common carotid arteries taken from bovine, porcine, ovine, leporine, murine-rat, and murine-mouse specimens. Data is generated using a scalable biaxial mechanical testing device following consistent circumferential (pressure-diameter) and axial (force-length) testing protocols. The structural mechanical response of carotids under equivalent loading, quantified by the deformed inner radius, deformed wall thickness, lumen area compliance and axial force, varies significantly among species but generally follows allometric scaling. Conversely, descriptors of the local mechanical response within the deformed arterial wall, including mean circumferential stress, mid-wall circumferential stretch, and mean axial stress, are relatively consistent across species. Unlike the larger animals studied, the diameter distensibility curves of murine specimens are non-monotonic and have a significantly higher value at 100 mmHg. Taken together, our results provide baseline structural and mechanical information for carotid arteries across a broad range of common animal models.
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Contractile Smooth Muscle and Active Stress Generation in Porcine Common Carotids
ASME Journal of Biomechanical Engineering
The mechanical response of intact blood vessels to applied loads can be delineated into passive and active components using an isometric decomposition approach. Whereas the passive response is due predominantly to the extracellular matrix (ECM) proteins and amorphous ground substance, the active response depends on the presence of smooth muscle cells (SMCs) and the contractile machinery activated within those cells. To better understand determinants of active stress generation within the…
The mechanical response of intact blood vessels to applied loads can be delineated into passive and active components using an isometric decomposition approach. Whereas the passive response is due predominantly to the extracellular matrix (ECM) proteins and amorphous ground substance, the active response depends on the presence of smooth muscle cells (SMCs) and the contractile machinery activated within those cells. To better understand determinants of active stress generation within the vascular wall, we subjected porcine common carotid arteries (CCAs) to biaxial inflation–extension testing under maximally contracted or passive SMC conditions and semiquantitatively measured two known markers of the contractile SMC phenotype: smoothelin and smooth muscle-myosin heavy chain (SM-MHC). Using isometric decomposition and established constitutive models, an intuitive but novel correlation between the magnitude of active stress generation and the relative abundance of smoothelin and SM-MHC emerged. Our results reiterate the importance of stretch-dependent active stress generation to the total mechanical response. Overall these findings can be used to decouple the mechanical contribution of SMCs from the ECM and is therefore a powerful tool in the analysis of disease states and potential therapies where both constituent are altered.
Other authorsSee publication -
The perivascular environment along the vertebral artery governs segment-specific structural and mechanical properties
Acta Biomaterialia
The vertebral arteries (VAs) are anatomically divided into four segments (V1-V4), which cumulatively transport blood flow through neck and ultimately form the posterior circulation of the brain. The vital physiological function of these conduit vessels depends on their geometry, composition and mechanical properties, all of which may vary among the defined arterial segments. Despite their significant role in blood circulation and susceptibility to injury, few studies have focused on…
The vertebral arteries (VAs) are anatomically divided into four segments (V1-V4), which cumulatively transport blood flow through neck and ultimately form the posterior circulation of the brain. The vital physiological function of these conduit vessels depends on their geometry, composition and mechanical properties, all of which may vary among the defined arterial segments. Despite their significant role in blood circulation and susceptibility to injury, few studies have focused on characterizing the mechanical properties of VAs, and none have investigated the potential for segmental variation that could arise due to distinct perivascular environments. In this study, we compare the passive mechanical response of the central, juxtaposed arterial segments of porcine VAs (V2 and V3) via inflation-extension mechanical testing. Obtained experimental data and histological measures of arterial wall composition were used to adjust parameters of structure-motivated constitutive models that quantify the passive mechanical properties of each arterial segment and enable prediction of wall stress distributions under physiologic loads and boundary conditions. Our findings reveal significant segmental differences in the arterial wall geometry and structure. Nevertheless, similar wall stress distributions are predicted in these neighboring arterial segments if calculations account for their specific perivascular environments. These findings allow speculation that segmental differences in wall structure and geometry are a consequence of a previously introduced principle of optimal operation of arteries, which ensures effective bearing of physiological load and a favorable mechanical environment for mechanosensitive vascular smooth muscle cells.
Other authorsSee publication -
A Mechanical Argument for Differential Performance of Coronary Artery Grafts
Journal of the Mechanical Behavior of Biomedical Materials
Coronary artery bypass grafting (CABG) acutely disturbs the homeostatic state of the transplanted vessel making retention of graft patency dependent on chronic remodeling processes. The time course and extent to which remodeling restores vessel homeostasis will depend, in part, on the nature and magnitude of the mechanical disturbances induced upon transplantation. In this investigation, biaxial mechanical testing and histology were performed on the porcine left anterior descending artery (LAD)…
Coronary artery bypass grafting (CABG) acutely disturbs the homeostatic state of the transplanted vessel making retention of graft patency dependent on chronic remodeling processes. The time course and extent to which remodeling restores vessel homeostasis will depend, in part, on the nature and magnitude of the mechanical disturbances induced upon transplantation. In this investigation, biaxial mechanical testing and histology were performed on the porcine left anterior descending artery (LAD) and analogs of common autografts, including the internal thoracic artery (ITA), radial artery (RA), great saphenous vein (GSV) and lateral saphenous vein (LSV). Experimental data were used to quantify the parameters of a structure-based constitutive model enabling prediction of the acute vessel mechanical response pre-transplantation and under coronary loading conditions. A novel metric Ξ was developed to quantify mechanical differences between each graft vessel in situ and the LAD in situ, while a second metric Ω compares the graft vessels in situ to their state under coronary loading. The relative values of these metrics among candidate autograft sources are consistent with vessel-specific variations in CABG clinical success rates with the ITA as the superior and GSV the inferior graft choices based on mechanical performance. This approach can be used to evaluate other candidate tissues for grafting or to aid in the development of synthetic and tissue engineered alternatives.
Other authorsSee publication -
Pulsatile Perfusion Bioreactor for Biomimetic Vascular Impedances
ASME Journal of Mechanical Devices
Intricate patterns of blood pressure and flow are generated by the cyclic contraction and relaxation of the heart and the coordinated opening and closing of valves. These pulsatile waves are augmented by the resistance, compliance, and inertance properties of the vasculature, resulting in unique hemodynamic characteristics present at distinct anatomically locations. In vivo these hemodynamically generated loads, transduced as physical signals into resident vascular cells, are crucial to the…
Intricate patterns of blood pressure and flow are generated by the cyclic contraction and relaxation of the heart and the coordinated opening and closing of valves. These pulsatile waves are augmented by the resistance, compliance, and inertance properties of the vasculature, resulting in unique hemodynamic characteristics present at distinct anatomically locations. In vivo these hemodynamically generated loads, transduced as physical signals into resident vascular cells, are crucial to the maintenance and preservation of healthy vascular physiology. Failure to recreate biomimetic loading in vitro however, can lead to pathological gene expression and aberrant remodeling. As a generalized approach to improve native and engineered blood vessels, we have designed, built, and tested a pulsatile perfusion bioreactor based on the concept of biomimetic impedances. Here the elements of an incubator-based culture system were formulaically designed to match the vascular impedance of a brachial artery using a 5-element electrohydraulic analog that incorporates both inherent (systemic) and added elements. Using freshly harvested saphenous veins, the relative expression of seven known mechanically sensitive remodeling genes were analyzed using a quantitative polymerase chain reaction (qPCR). Of these, we found plasminogen activator inhibitor-1 (SERPINE1) and fibronectin 1 (FN1) to be highly sensitive to differences between arterial- and venous-like culture conditions after 6 hours in our bioreactor. The analytical approach and biological confirmation provide a framework towards the general design of hemodynamic-mimetic vascular culture systems.
Patents
Courses
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Biomaterials
BMEN 271
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Biomechanics
BMEN 260
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Biomedical Circuits and Systems
BMEN 321
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Biomedical Measurement and Instrumentation
BMEN 361
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Biotransport Phenomena
BMEN 720
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Calculus I
MATH 141
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Calculus II
MATH 142
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Cell and Molecular Biology
BIOL 302
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Differential Equations
MATH 242
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English Word Origins
LING 405E
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Essentials of Physics I
PHYS 211
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Essentials of Physics II
PHYS 212
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Fluid Mechanics
ECHE 320
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General Chemistry I
CHEM 111
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General Chemistry II
CHEM 112
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Human Anatomy and Physiology I
EXSC 223
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Human Anatomy and Physiology II
BIOL 244
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Human Cell and Molecular Biology
BMEN 713
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Introduction to Logic I
PHIL 110
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Introductory Psychology
PSYC 101
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Model and Simulation of Biological Systems
BMEN 211
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Organic Chemistry I
CHEM 333
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Organic Chemistry II
CHEM 334
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Professional Development and Ethics I
BMEN 101
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Professional Development and Ethics II
BMEN 201
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Professional Development and Ethics III
BMEN 301
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Renaissance Art History
ARTH 524
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Science and Technology in World History
HIST 108
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Scientific Applications in Programming
CSCE 206
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Senior Design I
BMEN 427
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Soft Tissue Mechanics
BMEN 589
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Statistics for Engineers
STAT 509
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Stem Cell Engineering
BMEN 389J
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Super Bowl of Advertising
SCHC 472C
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Thermodymanics and Kinetics
BMEN 390
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Tissue Engineering
BMEN 589J
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Transport in Biological Systems
BMEN 354
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Vector Calculus
MATH 241
Projects
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Drug Delivery for Periodontal Tissue Regeneration
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Layer-by-Layer assembly of nanocolloidal coatings on electrospun (poly)caprolactone mats for periodontal tissue engineering
Other creators -
Languages
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Spanish
Limited working proficiency
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English
Native or bilingual proficiency
Organizations
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American Heart Association
Member
- Present -
Carolina Biotechnology Group
VP of Development; Vice Chair, Board of Directors
- Present- Connected with School of Law to incorporate nonprofit organization with 501(c)(3) status - Built relationships with leaders in the biotechnology and entrepreneurship industries in SC - Currently establishing CBG as provider of free consulting services to growing biotech companies in SC www.carolinabiotechgroup.com
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American Association for the Advancement of Science
Student Member
- Present -
Biomedical Engineering Society
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- Present
More activity by David
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I’m SO excited to share this news. The team at Adona Medical is amazing and have accomplished so much. It’s a blessing to have the opportunity to…
I’m SO excited to share this news. The team at Adona Medical is amazing and have accomplished so much. It’s a blessing to have the opportunity to…
Liked by David Prim, PhD
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Locust Walk is pleased to welcome to the team Mark Diamond, a senior pharmaceutical executive with a demonstrated record of achievement and…
Locust Walk is pleased to welcome to the team Mark Diamond, a senior pharmaceutical executive with a demonstrated record of achievement and…
Liked by David Prim, PhD
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𝐀 𝐍𝐞𝐰 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐭𝐮𝐝𝐲 𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐞𝐬 𝐭𝐡𝐞 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦 𝐨𝐟 𝐀𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐅𝐑𝐀𝐌𝐄 𝐄𝐱𝐭𝐞𝐫𝐧𝐚𝐥 𝐒𝐮𝐩𝐩𝐨𝐫𝐭…
𝐀 𝐍𝐞𝐰 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐒𝐭𝐮𝐝𝐲 𝐄𝐯𝐚𝐥𝐮𝐚𝐭𝐞𝐬 𝐭𝐡𝐞 𝐌𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐦 𝐨𝐟 𝐀𝐜𝐭𝐢𝐨𝐧 𝐨𝐟 𝐅𝐑𝐀𝐌𝐄 𝐄𝐱𝐭𝐞𝐫𝐧𝐚𝐥 𝐒𝐮𝐩𝐩𝐨𝐫𝐭…
Liked by David Prim, PhD
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Great interview with Philip Hemme : thanks for visiting us in Boston and for the great conversation! Some topics that might be of interest: M&A…
Great interview with Philip Hemme : thanks for visiting us in Boston and for the great conversation! Some topics that might be of interest: M&A…
Liked by David Prim, PhD
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Another completed CEO search, congratulations Stefan! I know you will be a huge success at HighLife.
Another completed CEO search, congratulations Stefan! I know you will be a huge success at HighLife.
Liked by David Prim, PhD
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After all of the parking tickets I got while at UNC it was great to get a priority spot today .
After all of the parking tickets I got while at UNC it was great to get a priority spot today .
Liked by David Prim, PhD
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I am excited to announce that I have joined the External Innovation team at Lilly, where I will be focusing on our Immunology BD and Partnering…
I am excited to announce that I have joined the External Innovation team at Lilly, where I will be focusing on our Immunology BD and Partnering…
Liked by David Prim, PhD
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Honored to join this fantastic group of panelist to discuss an important topic in the medtech ecosystem! #LSIEurope24
Honored to join this fantastic group of panelist to discuss an important topic in the medtech ecosystem! #LSIEurope24
Liked by David Prim, PhD
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The anti-electric car thing on the right seems odd given some of the lip service to American exceptionalism. One aspect of our exceptionalism is our…
The anti-electric car thing on the right seems odd given some of the lip service to American exceptionalism. One aspect of our exceptionalism is our…
Liked by David Prim, PhD
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Always great chatting biotech with Brad Loncar!
Always great chatting biotech with Brad Loncar!
Liked by David Prim, PhD
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Gilde Healthcare (#LSIEurope24 Investor) is a specialized healthcare investor managing over $2.6 billion across two fund strategies: Venture&Growth…
Gilde Healthcare (#LSIEurope24 Investor) is a specialized healthcare investor managing over $2.6 billion across two fund strategies: Venture&Growth…
Liked by David Prim, PhD
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