Activity
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A novel regulatory approach for Generative AI based clinical applications. Generative AI and discussions around it has been happening in many…
A novel regulatory approach for Generative AI based clinical applications. Generative AI and discussions around it has been happening in many…
Liked by Craig Mermel
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“Think about the idea of planting a device that can change the outcome of diseases like ALS, stroke, traumatic brain injury—so many things that we…
“Think about the idea of planting a device that can change the outcome of diseases like ALS, stroke, traumatic brain injury—so many things that we…
Liked by Craig Mermel
Experience & Education
Publications
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The 2013 symposium on pathology data integration and clinical decision support and the current state of field.
Journal of pathology informatics
Pathologists and informaticians are becoming increasingly interested in electronic clinical decision support for pathology, laboratory medicine and clinical diagnosis. Improved decision support may optimize laboratory test selection, improve test result interpretation and permit the extraction of enhanced diagnostic information from existing laboratory data. Nonetheless, the field of pathology decision support is still developing. To facilitate the exchange of ideas and preliminary studies, we…
Pathologists and informaticians are becoming increasingly interested in electronic clinical decision support for pathology, laboratory medicine and clinical diagnosis. Improved decision support may optimize laboratory test selection, improve test result interpretation and permit the extraction of enhanced diagnostic information from existing laboratory data. Nonetheless, the field of pathology decision support is still developing. To facilitate the exchange of ideas and preliminary studies, we convened a symposium entitled: Pathology data integration and clinical decision support.
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microRNA Expression during Trophectoderm Specification
PLOS One
Abstract
Background
Segregation of the trophectoderm from the inner cell mass of the embryo represents the first cell-fate decision of mammalian development. Transcription factors essential for specifying trophectoderm have been identified, but the role of microRNAs (miRNAs) in modulating this fate-choice has been largely unexplored. We have compared miRNA expression in embryonic stem cell (ESC)-derived trophectoderm and in staged murine embryos to identify a set of candidate miRNAs…Abstract
Background
Segregation of the trophectoderm from the inner cell mass of the embryo represents the first cell-fate decision of mammalian development. Transcription factors essential for specifying trophectoderm have been identified, but the role of microRNAs (miRNAs) in modulating this fate-choice has been largely unexplored. We have compared miRNA expression in embryonic stem cell (ESC)-derived trophectoderm and in staged murine embryos to identify a set of candidate miRNAs likely to be involved in trophectoderm specification.
Results
We profiled embryonic stem cells (ESCs) as they were induced to differentiate into trophectodermal cells by ectopic expression of HRas/Q61L. We also profiled murine embryos at progressive stages of preimplantation development (zygote, 2-cell, 4-cell, 8-cell, morula, and blastocyst), which includes the time window in which the trophectoderm is specified in vivo. Q61L/H
Conclusions
We describe miRNA expression changes that occur during trophectoderm specification and validate that our in vitro system faithfully recapitulates trophectoderm specification in vivo. By comparing our in vitro and in vivo datasets, we have identified a minimal set of candidate miRNAs likely to play a role in trophectoderm specification. These miRNAs are predicted to regulate a host of development-associated target genes, and many of these miRNAs have previously reported roles in development and differentiation. Additionally, we highlight a number of miRNAs whose tight developmental regulation may reflect a functional role in other stages of embryogenesis. Our embryo profiling data may be useful to investigators studying trophectoderm specification and other stages of preimplantation development.
More activity by Craig
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#BCI - State of the Art, Art of the Future. We're back for another year of BCI vision, mission, and reality. Come to #EMBC2024 on July 18 to hear…
#BCI - State of the Art, Art of the Future. We're back for another year of BCI vision, mission, and reality. Come to #EMBC2024 on July 18 to hear…
Liked by Craig Mermel
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Putting in a feeler out there looking for a Microfabrication Process Engineer with 3+ yrs Photolithography and MEMS experience in Texas. Hit me up if…
Putting in a feeler out there looking for a Microfabrication Process Engineer with 3+ yrs Photolithography and MEMS experience in Texas. Hit me up if…
Liked by Craig Mermel
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Introducing NV-Embed, a generalist embedding model that ranks No. 1 on the MTEB Benchmark, which includes 56 diverse tasks, using only publicly…
Introducing NV-Embed, a generalist embedding model that ranks No. 1 on the MTEB Benchmark, which includes 56 diverse tasks, using only publicly…
Liked by Craig Mermel
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I read 1440's news digest every day as a part of my morning reading routine. It's always great to see when they pick up #neurotech stories and I can…
I read 1440's news digest every day as a part of my morning reading routine. It's always great to see when they pick up #neurotech stories and I can…
Liked by Craig Mermel
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We recently announced our clinical study with Mount Sinai Health System, led by our outstanding collaborators Ignacio Saez, PhD and Dr Joshua…
We recently announced our clinical study with Mount Sinai Health System, led by our outstanding collaborators Ignacio Saez, PhD and Dr Joshua…
Shared by Craig Mermel
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In April, I got to watch the Precision Neuroscience team test its technology during a brain surgery at the Mount Sinai Health System in New York…
In April, I got to watch the Precision Neuroscience team test its technology during a brain surgery at the Mount Sinai Health System in New York…
Liked by Craig Mermel
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Regardless of market conditions, there are ways to optimize portfolios to make the most of your assets. These strategies can help.
Regardless of market conditions, there are ways to optimize portfolios to make the most of your assets. These strategies can help.
Liked by Craig Mermel
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After two amazing years at Neuralink, I've decided it's time to resign and continue on my journey. I'm forever grateful to the team for being…
After two amazing years at Neuralink, I've decided it's time to resign and continue on my journey. I'm forever grateful to the team for being…
Liked by Craig Mermel
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Christian Whitchurch thanks for pointing me to this podcast on Precision Neuroscience, a brain computer interface company. what a great use of…
Christian Whitchurch thanks for pointing me to this podcast on Precision Neuroscience, a brain computer interface company. what a great use of…
Liked by Craig Mermel
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Great workshop today about the latest in human applications of BCIs at the American Association of Neurological Surgeons (AANS) meeting! Thanks for…
Great workshop today about the latest in human applications of BCIs at the American Association of Neurological Surgeons (AANS) meeting! Thanks for…
Liked by Craig Mermel
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Awesome paper co-authored by a few folks from my team!
Awesome paper co-authored by a few folks from my team!
Liked by Craig Mermel
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Today is my 8-year Googleversary! 19-year-old Amy, fresh out of brain surgery who was told she might not survive to age 20, would never have dreamed…
Today is my 8-year Googleversary! 19-year-old Amy, fresh out of brain surgery who was told she might not survive to age 20, would never have dreamed…
Liked by Craig Mermel
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