“I was glad to work with Bradlee on the Document and Email Management projects. He is a great Product Manager with huge analytic experience and strategic vision. He's very responsive to feedback and requests, full of ideas, and gets along with everyone at the team. He has shown a good example of how proactive and persistent we all (team) should be in pursuing our common goals. It was such a pleasure to work with Bradlee!”
About
Activity
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The Outdoor Industry is seeing unprecedented discounting of soft goods in 2024. I give a four-year history of how we got here, from the COVID demand…
The Outdoor Industry is seeing unprecedented discounting of soft goods in 2024. I give a four-year history of how we got here, from the COVID demand…
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✨ Inspire 2024 will be here soon and we invite you to join us for insightful sessions, hands-on interactive workshops, unparalleled networking…
✨ Inspire 2024 will be here soon and we invite you to join us for insightful sessions, hands-on interactive workshops, unparalleled networking…
Liked by Bradlee Duncan
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Work hard, play (quite literally) harder 🎮 #LifeatBound #FounderEnergy
Work hard, play (quite literally) harder 🎮 #LifeatBound #FounderEnergy
Liked by Bradlee Duncan
Experience & Education
Licenses & Certifications
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Building and Leading Conscious Enterprises
EGADE Business School del Tecnológico de Monterrey
Issued -
Moving to Net Zero and The Rise of The Voluntary Carbon Market
Saïd Business School, University of Oxford
Issued -
Bay Area Entrepreneurship and Innovation
University of California, Berkeley, Haas School of Business
Issued -
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Volunteer Experience
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Facilitator
Oxford Climate Tech Initiative
- 2 years
Environment
Working with a team at Oxford Saïd Business School to build the Oxford Climate Tech Initiative (OxCTI) which serves to close gaps in networking, knowledge, and partnerships in and around Oxford for like-minded individuals looking for engaging in new and emerging technologies to impact our environment for the better. Learn more at https://www.oxclimate.tech
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Refugee Family Mentor
International Rescue Committee
- 9 months
Human Rights
Helped displaced families from Syria and Iraq resettle in Utah, USA. Assisted with job applications, networking, tutoring/school work doctor appointments, and simply being available as they built a new life. Grateful for lifelong friendships that resulted from the experience.
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Race Event Director
University of Utah Cycling Team
- 3 years 6 months
Health
Responsible for design, hosting, and advancement of collegiate and regional multi-event cycling races; includes procurement and negotiation of outside funding/partnerships, securing race sponsorship, designing courses, organizing staff and volunteers, and maintaining financial viability of the events and team.
Close coordination with the charity, Bikes4Kids, to ensure easy access to bicycles for children in under-served populations in the region. -
Publications
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Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex
Diabetes
Vascular dysfunction that accompanies obesity and insulin resistance may be mediated by lipid metabolites. We sought to determine if vascular ceramide leads to arterial dysfunction and to elucidate the underlying mechanisms. Pharmacological inhibition of de novo ceramide synthesis, using the Ser palmitoyl transferase inhibitor myriocin, and heterozygous deletion of dihydroceramide desaturase prevented vascular dysfunction and hypertension in mice after high-fat feeding. These findings were…
Vascular dysfunction that accompanies obesity and insulin resistance may be mediated by lipid metabolites. We sought to determine if vascular ceramide leads to arterial dysfunction and to elucidate the underlying mechanisms. Pharmacological inhibition of de novo ceramide synthesis, using the Ser palmitoyl transferase inhibitor myriocin, and heterozygous deletion of dihydroceramide desaturase prevented vascular dysfunction and hypertension in mice after high-fat feeding. These findings were recapitulated in isolated arteries in vitro, confirming that ceramide impairs endothelium-dependent vasorelaxation in a tissue-autonomous manner. Studies in endothelial cells reveal that de novo ceramide biosynthesis induced protein phosphatase 2A (PP2A) association directly with the endothelial nitric oxide synthase (eNOS)/Akt/Hsp90 complex that was concurrent with decreased basal and agonist-stimulated eNOS phosphorylation. PP2A attenuates eNOS phosphorylation by preventing phosphorylation of the pool of Akt that colocalizes with eNOS and by dephosphorylating eNOS. Ceramide decreased the association between PP2A and the predominantly cytosolic inhibitor 2 of PP2A. We conclude that ceramide mediates obesity-related vascular dysfunction by a mechanism that involves PP2A-mediated disruption of the eNOS/Akt/Hsp90 signaling complex. These results provide important insight into a pathway that represents a novel target for reversing obesity-related vascular dysfunction.
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Inhibiting vascular ceramide synthesis prevents arterial dysfunction and hypertension in mice with diet-induced obesity
The Journal of the Federation of American Societies for Experimental Biology
Ceramide accumulation in vascular smooth muscle might contribute to obesity-related arterial dysfunction and hypertension. To test this hypothesis, mice were treated with myriocin (M), an inhibitor of an enzyme required for ceramide biosynthesis (i.e., serine palmitoyltransferase). 10-week old mice consumed chow containing 45% (HF, n=20) or 10% (Con, n=20) fat ± M (0.3 mg/kg i.p., n=10) or vehicle (V; saline i.p., n=10) for 14 weeks. Mean (MAP), systolic (SBP), and diastolic (DBP) blood…
Ceramide accumulation in vascular smooth muscle might contribute to obesity-related arterial dysfunction and hypertension. To test this hypothesis, mice were treated with myriocin (M), an inhibitor of an enzyme required for ceramide biosynthesis (i.e., serine palmitoyltransferase). 10-week old mice consumed chow containing 45% (HF, n=20) or 10% (Con, n=20) fat ± M (0.3 mg/kg i.p., n=10) or vehicle (V; saline i.p., n=10) for 14 weeks. Mean (MAP), systolic (SBP), and diastolic (DBP) blood pressures then were recorded via telemetry for 6 x 24-h periods followed by excision of the aorta and femoral arteries. Vascular ceramide (pmol ceramide/mg aorta) increased (p<0.05) from 17±4 in Con-V mice to 30±3 in HF-V animals, and was suppressed in HF-M animals (10±1). Elevated (*p<0.05) MAP, SBP, and DBP in HF-V vs. Con-V mice was prevented in HF-M animals. Values in the Table represent the mean±SE of 6 dark/active cycles. Impaired (*p<0.05) acetylcholine (ACh)-evoked vasorelaxation (wire-myography) in femoral arteries from HF-V vs. Con-V mice was prevented in HF-M animals. Sodium-nitroprusside-evoked vasorelaxation was similar among groups. ACh values represent % vasorelaxation.
Languages
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English
Native or bilingual proficiency
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Portuguese
Full professional proficiency
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Spanish
Limited working proficiency
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Arabic
Elementary proficiency
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French
Elementary proficiency
Recommendations received
1 person has recommended Bradlee
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