Anne Urfer-Buchwalder, PhD

San Francisco Bay Area Contact Info
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University of Strasbourg, Strasbourg, France

About

Entrepreneur with a broad and international experience in biotechnology start-up and…

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Experience & Education

  • Selonterra, Inc.

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Publications

  • Identification of a Nuclear Respiratory Factor 1 Recognition Motif in the Apolipoprotein E Variant APOE4 linked to Alzheimer’s Disease

    Scientific Reports

    Alzheimer’s disease is a progressive neurodegenerative disorder that affects tens of millions of people worldwide. The most clinically significant, prevalent gene variant associated with late onset AD is APOE4, a DNA variant of the apolipoprotein E gene. Selonterra discovered that the APOE4 variant is part of a short sequence repeat typically observed in DNA regulatory regions (transcriptional enhancers). The single nucleotide change from APOE3 to APOE4 generates a de novo binding motif for the…

    Alzheimer’s disease is a progressive neurodegenerative disorder that affects tens of millions of people worldwide. The most clinically significant, prevalent gene variant associated with late onset AD is APOE4, a DNA variant of the apolipoprotein E gene. Selonterra discovered that the APOE4 variant is part of a short sequence repeat typically observed in DNA regulatory regions (transcriptional enhancers). The single nucleotide change from APOE3 to APOE4 generates a de novo binding motif for the transcription factor NRF1, a protein known to regulate key metabolic and mitochondrial genes. This finding suggests that the APOE4 variant mediates its disease-causing effects at the DNA level by controlling the expression of genes in its vicinity. This mechanism allows for the integration of environmental triggers known to influence AD and the tissue-specific and spatial progression of AD neurodegeneration.

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Languages

  • French

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  • English

    Full professional proficiency

  • German

    Professional working proficiency

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