Boston, Massachusetts, United States
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Articles by Anan
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1st Year Anniversary Special Event from the MA BioPharma Networking Group (MABPNG)
1st Year Anniversary Special Event from the MA BioPharma Networking Group (MABPNG)
By Anan Natarajan, MBA
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Official Launch of MABPNG Life Sciences Networking Group on Oct 13th in Cambridge, MA - Come Join Us!!!
Official Launch of MABPNG Life Sciences Networking Group on Oct 13th in Cambridge, MA - Come Join Us!!!
By Anan Natarajan, MBA
Experience & Education
Volunteer Experience
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Member
Benevolent and Protective Order of Elks
- Present 3 years 5 months
Social Services
Elks Lodges bring so much more to their communities than just a building, golf course or pool. They are places where neighbors come together, families share meals, and children grow up. Elks invest in their communities through programs that help children grow up healthy and drug-free, meet the needs of today’s veterans, and improve the quality of life.
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Mentor, Volunteer
Junior Achievement USA
- Present 5 years
Education
Professional | Business Mentor and Educational Volunteer focused on guiding and empowering middle and high school students through professional development, counseling and training programs to achieve their life aspirations and professional goals.
Publications
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Three distinct human thymopoietins are derived from alternatively spliced mRNAs.
Proc Natl Acad Sci U S A. 1994 July 5; 91(14): 6283–6287. PMCID: PMC44185
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC44185/?tool=pmcentrez
Thymopoietin (TP) was originally isolated as a 5-kDa 49-aa protein from bovine thymus in studies of the effects of thymic extracts on neuromuscular transmission and was subsequently observed to affect T-cell differentiation and function. We now report the isolation of cDNA clones for three alternatively spliced mRNAs that encode three distinct human T-cell TPs. Proteins encoded by these mRNAs, which we have named TP alpha (75…http://www.ncbi.nlm.nih.gov/pmc/articles/PMC44185/?tool=pmcentrez
Thymopoietin (TP) was originally isolated as a 5-kDa 49-aa protein from bovine thymus in studies of the effects of thymic extracts on neuromuscular transmission and was subsequently observed to affect T-cell differentiation and function. We now report the isolation of cDNA clones for three alternatively spliced mRNAs that encode three distinct human T-cell TPs. Proteins encoded by these mRNAs, which we have named TP alpha (75 kDa), TP beta (51 kDa), and TP gamma (39 kDa), contain identical N-terminal regions, including sequences nearly identical to that of the originally isolated 49-aa protein, but divergent C-terminal regions. TP mRNAs are expressed in many tissues, most abundantly in adult thymus and fetal liver of the tissues so far examined. Distinct structural domains and functional motifs in TPs alpha, beta, and gamma suggest that the proteins have unique functions and may be directed to distinct subcellular compartments. -
Lamina-associated polypeptide 2, isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene.
Wikipedia / Thymopoietin
http://en.wikipedia.org/wiki/Thymopoietin
Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the…http://en.wikipedia.org/wiki/Thymopoietin
Thymopoietin is a protein involved in the induction of CD90 in the thymus. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2 (lamina-associated polypeptide 2). LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.
Projects
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Results Driven Strategic Leadership
- Present
Integrating Strategy and Execution for Continuous Process Improvements and Professional Development
Languages
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English
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Spanish
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Organizations
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Executive Roundtables | Networking Groups: ExecuNet (Boston, Stamford - SERT, Hartford), HotShots Boston, NEHEN, SENG-NE, NEAG - Northeast Executive Advisory Group, Westport Group, Healthcare Pioneers, Inventors Association of CT, MABPNG
Founder, Leader, Speaker, Steering Committee Member, Collaborator
- Present
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