Trailhead Biosystems

Exciting news for hematology researchers! Soon launching: TrailBio™ Hematopoietic Progenitor Cells (HPCs). Derived from iPSCs, these cells are capable of multilineage differentiation. Want to be the first to know when TrailBio™ HPCs hit the market? Visit https://lnkd.in/gb6f6Sd8 to sign up for our newsletter and receive the latest updates. #HematopoieticCells #StemCells #Hematology #DrugDiscovery #RegenerativeMedicine #iPSCs

Need a custom disease or patient-specific model? Trailhead can differentiate your own lines into the cell type you need. Conduct research on Trailhead's optimized and validated iPSC-derived cell types, created on the cell line you require -- such as our endothelial cells, pictured here. To learn more about custom differentiation for disease modeling and other purposes, visit: https://lnkd.in/gkEbXXtA #endothelialcells #vascularresearch #PAD #Peripheralarterialdisease #Atherosclerosis #coronaryarterydisease #Bloodclots #stroke

Today, on Dravet Syndrome Awareness Day, we shed light on this rare and severe form of epilepsy that begins in infancy. Dravet syndrome is a lifelong condition characterized by prolonged seizures, developmental delays, and a range of associated health issues. At Trailhead Biosystems, our team is dedicated to advancing research into Dravet syndrome and other epileptic disorders by researching how to optimize protocols to create MGE-derived interneurons from iPSCs. These specialized neurons, originating from the medial ganglionic eminence, play a pivotal role in regulating neuronal activity and maintaining a balanced excitation-inhibition ratio in the brain. We want to provide researchers with physiologically relevant human cell models. We aim to enable crucial studies into the disruptions in neural circuitry and imbalances that contribute to the development of Dravet syndrome.  Through our commitment to stem cell research and the creation of disease-relevant models, we strive to contribute to a deeper understanding of Dravet syndrome and drive the development of effective treatments for this rare and challenging form of epilepsy. #DravetSyndromeAwarenessDay #RareEpilepsyAwareness #StemCellResearch #MGEInterneurons #TrailheadBiosystems #EpilepsyModels #DravetTherapies #UnderstandingDravet #NeuronalCircuits #InhibitionExcitation #RareDisease

We are thrilled to announce that Vascular Leptomeningeal Cells (VLMCs) are now available in a pre-released format on Trailhead's website! These unique cells, derived from iPSCs, offer exciting new possibilities for researchers investigating neurovascular interactions, blood-brain barrier function, and neurological disorders. Key features of Trailhead's VLMCs: ✅ Derived from human iPSC lines using proprietary protocols ✅ Suitable for a wide range of applications, including co-culture models, disease modeling, and drug screening ✅ Backed by Trailhead's commitment to quality, reproducibility, and customer support By adding VLMCs to our catalog, we aim to empower researchers with novel tools to advance our understanding of neurovascular biology and unlock new therapeutic avenues. To learn more about Trailhead's VLMCs and how they can support your research, please visit our website at https://lnkd.in/gXHzKF6G Feel free to also contact us directly. Our knowledgeable staff is ready to assist you in selecting the best cells for your specific project needs and provide guidance on their applications. Discover the potential of VLMCs and take your neurovascular research to new heights with Trailhead! 🚀 #VascularLeptomeningealCells #VLMCs #neurovascularresearch #bloodbrainbarrier #Trailhead #innovativecellmodels #trailbio #bbb #iPSC #differentiation

World Sickle Cell Day, observed annually on June 19th, raises global awareness about this inherited blood disorder that affects millions worldwide.  Sickle cell disease is caused by a mutation in the hemoglobin gene, leading to the production of abnormal sickle-shaped red blood cells. These deformed cells can obstruct blood flow, causing pain, organ damage, and life-threatening complications. Our scientists are committed to advancing research into sickle cell disease by unlocking the potential of stem cells to generate various mesoderm-derived cell types, including blood cells. Through innovative methods, we aim to one day assist researchers studying sickle cell diseases by differentiating their disease specific iPSCs into physiologically relevant models. By providing researchers with these disease-specific models, we can one day enable crucial studies into the underlying mechanisms driving sickle cell pathology and the development of novel therapeutic strategies. Our ultimate goal is to contribute to the global effort to find a cure for sickle cell disease and alleviate the suffering of those affected by this debilitating condition. Through our commitment to stem cell research and the creation of disease-relevant models, we strive to pave the way for groundbreaking treatments that could improve the quality of life for sickle cell warriors worldwide. #WorldSickleCellDay #SickleCellAwareness #SickleCellWarriors #CureSickleCell #StemCellResearch #MesodermCells #TrailheadBiosystems #SickleCellModels #FightingSickleCell #SickleCellTherapies #SickleCellCure

Autistic Pride Day is celebrated annually on June 18th.  Today, we embrace the unique perspectives and strengths of individuals on the autism spectrum. While autism spectrum disorder (ASD) is a complex neurodevelopmental condition, ongoing research aims to shed light on its underlying neural circuitry and brain connectivity disruptions. At Trailhead, our scientists are dedicated to creating MGE-derived interneurons from IPSCs. These specialized neurons, originating from the medial ganglionic eminence, play a pivotal role in the development of autism. By providing relevant human cell models to researchers, we strive to enable crucial studies into the cellular and molecular mechanisms underlying ASD. Our ultimate goal is to contribute to a deeper understanding of autism and pave the way for potential research that could improve the quality of life for those on the spectrum. Through our scientific advancements, we embrace neurodiversity and strive to empower individuals with autism to thrive. #AutisticPrideDay #AutismAwareness #AutismResearch #StemCellModels #MGEInterneurons #TrailheadBiosystems #EmbracingNeurodiversity #AutismTherapies #UnderstandingAutism #AutismCellularModels #SupportingAutism

On World Blood Donor Day, we celebrate the selfless acts of millions of blood donors worldwide who help save countless lives every year.  However, the persistent global shortage of blood products highlights the need for new solutions to meet the ever-increasing demand.  By developing innovative methods to differentiate iPSCs into diverse mesodermal lineages, Trailhead aims to provide researchers with a renewable source of human blood cells for research and therapeutic applications. Our pioneering work brings the world closer to the possibility of manufacturing universal blood products on a large scale, reducing medicine's reliance on traditional blood donations.�� Our commitment to advancing stem cell technology for blood cell production exemplifies our vision of a future where no patient is denied access to life-saving blood transfusions due to shortages.  For more information about Trailhead's pursuit to differentiate iPSCs into the mesodermal fate, visit https://lnkd.in/gk5Ws-4W As we celebrate the generosity of blood donors today, we also look ahead with hope to a future where their noble sacrifices may no longer be necessary, thanks to the transformative power of stem cell research. #WorldBloodDonorDay #BloodDonorHeroes #GiveBlood #SaveLivesGiveBlood #BloodDonorAwareness #ThankABloodDonor #StemCellBlood #StemCellTherapies #iPSCBloodCells #UniversalBloodProducts #TrailheadBiosystems #RenewableBloodSource #StemCellSolutions #EndBloodShortages #ModernBloodBanking

Fatty Liver Awareness Day is observed annually on June 13th. Today, we shed light on the growing prevalence of non-alcoholic fatty liver disease (NAFLD) and its more severe form, non-alcoholic steatohepatitis (NASH). These conditions, characterized by the buildup of excess fat in the liver, can lead to severe liver damage and cirrhosis if left unchecked.  That is why scientists at Trailhead diligently work to derive hepatocytes and other liver cell types from hiPSCs. By developing disease-relevant models for researchers, we hope to enable the unraveling of underlying disease mechanisms and curating possible cures.  Ultimately, through our scientific advances, we strive to help offer solutions to all those affected by unhealthy livers. #FattyLiverAwareness #FightFattyLiver #NAFLDAwareness #NASHAwareness #LiverHealth #HealthyLivers #StemCellLiverModels #TrailheadBiosystems #CureNAFLD #ReverseFattyLiver #EndNASH #ProtectYourLiver #FattyLiverFighters #LiverWarriors

We had an absolute blast at BIO 2024! Reconnecting with familiar faces and making so many new connections made this year's event truly special. The energy, insights, and camaraderie were off the charts. From thought-provoking panels to casual networking, every moment sparked engaging conversations and valuable takeaways. A huge thank you to the organizers for putting together such an outstanding experience. As we part ways, already counting down the days until the next BIO, one thing's for sure - our community just keeps getting stronger. Until we meet again, friends! #BIO2024 #BiotechCommunity #NetworkingWin #BIO2025

BIO24 has concluded and the biotech executives are heading home. So are we, at Trailhead Biosystems. We thank all those we met, both those we planned to meet in advance but as much also those we met unexpectedly and learned from. Opportunities are everywhere - but only if we meet! BIO is an event that needs to be experienced - it is difficult to describe the intensity. The skies of future biotechnology are awaiting many new companies and cures. After BIO24 it feels as the turbulent time of the biotechnology sector is calming. That is good, as perfection takes time and continuity of focus gives results. If you think long acting Glp1R agonists came overnight, think again. Drugs, Biologics, and Cell Therapies are difficult. Very difficult. This industry takes Time. Commitment. Investment. Trailhead Biosystems #bio24 #cellandgenetherapy #trailbio #hddoe #biotechnology #t1d #hsct #futuremedicine #ipsc #biomanufacturing