We couldn’t agree more…. #cryoem #drugdiscovery
NanoImaging Services
Research Services
San Diego, CA 4,397 followers
Cryo-EM for Drug Discovery. Gene-to-Structure, Structural Biology, Nanoparticle Characterization on Glacios & Krios.
About us
Visualizing biomolecular structures through cryo-EM studies can provide insight into multiple stages of the drug development process, from target identification through formulation and manufacturing. NanoImaging Services (NIS) is the industry leader with the longest history in cryo-EM, with more cryo-EM scientists and TEM microscopes than any provider in North America. NIS is focused on: Structural Biology: High-resolution data collection and single-particle analysis for structure-based drug design. Average sample-to-structure in only 4 weeks! Nanoparticle Characterization: Complete morphology assessment to inform size, shape, uniformity, purity, and cargo encapsulation, with quantitative analysis. R&D and GMP-compliant services available. By utilizing state-of-the-art technology and deep expertise, NIS makes cryo-EM accessible to companies of all sizes across the drug discovery pipeline and accelerates the development of new and life-changing therapeutics.
- Website
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http://www.nanoimagingservices.com/
External link for NanoImaging Services
- Industry
- Research Services
- Company size
- 51-200 employees
- Headquarters
- San Diego, CA
- Type
- Privately Held
- Founded
- 2007
- Specialties
- CryoEM, CRO, DrugDiscovery, DrugDevelopment, ProteinStructure, Biophysics, Antibodies, Virology, Liposomes, Exosomes, Nanoparticles, AAV, TEM, Electron Microscopy, cryo-EM, LNPs, VLPs, Structural Biology, biophysical characterization, protein construct design, protein structure solution, Structure Based Drug Design, and SBDD
Locations
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Primary
Get directions
4940 Carroll Canyon Road
Suite 115
San Diego, CA 92121, US
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Get directions
4 Gill St
Woburn, Massachusetts 01801, US
Employees at NanoImaging Services
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Kristin Rider
Chief Commercial Officer (CCO) at NanoImaging Services. Making cryo-EM accessible to companies of all stages and sizes in the drug discovery pipeline.
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Maria (Mandy) Janssen
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Giovanna Scapin
Chief Scientific Officer at NanoImaging Services
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Janine LeBlanc
Chief Financial Officer
Updates
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📣 It's tomorrow! Are you interested in…? ❓ Small proteins under ~100 kDa, #membrane & #soluble ❓ Improving #cryoEM workflows on a #Glacios microscope ❓ Advancements in cryo-EM #structuredetermination 👨🔬 Join NIS Senior Scientist, Dr. Claudio Catalano for a #webinar about his everyday experience with cryo-EM, and ask your questions live! ✏ Register now: https://lnkd.in/gTg_C-gz
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🤔 Ever wondered how the nanostructure of LNPs affects RNA delivery? 👨🔬 This important question is explored in “Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm” by Lining Zheng et. al. 🔬 Using cryo-TEM, they visualize siRNA-LNPs with different nanostructures including lamellar, inverse hexagonal, and bicontinuous cubic. Interestingly, they show that bicontinuous cubic LNPs have greater in vitro fusogenicity and transfection efficiency than lamellar LNPs. 💡The study provides evidence that #LNP nanostructure influences #RNA delivery efficiency. 📑 Read the paper now: https://lnkd.in/gsaHsjDu 📩 Reach out to us today to see how we can apply #cryoTEM to your #LNPs to provide critical insights.
Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm | PNAS
pnas.org
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⏰ One week away! If you’re working with small #proteins, a #Glacios TEM, or are just curious about advancements in #cryoEM, this is the #webinar for you! 👨🔬 Join Dr. Claudio Catalano to hear about two recent successes in #structuredetermination of proteins under ~100 kDa, and ask him your questions live! ✏ Register now: https://lnkd.in/ggGN66F6
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🔑 Unlock precise particle size distribution analysis with our AI-powered image analysis tools. 🔬 Our automated analysis of #cryoTEM images for #LNPs or #liposomes provides precise particle tracing, distribution curves, mean AED, mean/max Feret diameters, D10, D50, D90, span, and circularity. 💡 Learn more: https://lnkd.in/gtPGGKgD
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🔬 Keep up with the latest in #cryoEM! 📆 Join us for a webinar about advances in #structuredetermination of small proteins. 👀 Learn about or new #AI-powered particle sizing analysis for #cryoTEM images.
Under the Microscope with NIS
NanoImaging Services on LinkedIn
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NanoImaging Services is hosting Webinar: High-Resolution Structure Determination of Small Proteins by Cryo-. Make sure to attend it on July 17.
📣 Cryo-EM structure determination of molecules smaller than 100 kDa has historically been challenging. 👨🔬 Join NIS Senior Scientist, Dr. Claudio Catalano, for a webinar "High-Resolution Structure Determination of Small Proteins by Cryo-EM Using a Glacios Microscope" July 17th, 11am PST / 2pm EST, demonstrating that routine cryo-EM structure determination is possible on smaller proteins. 🔬 In this webinar, you’ll hear about: - Obstacles in #cryoEM structure determination of small proteins. - Strategies for overcoming these obstacles. - Two case studies detailing the entire #structuredetermination process, #HiTehA, a ~100 kDa alpha-helical membrane protein, and #HSA, a ~60 kDa soluble protein. ✏ Register now: https://lnkd.in/gwMDthtW
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💡 Particle size distribution is a vital analysis for nanoparticle formulations. 🔬 NIS’s advanced AI powered image analysis tools, developed in-house, can provide quantitative data on your #LNPs & #liposomes, #viruses & #VLPs, #ironNPs, or any sample you have. 📩 Get in touch today to see how #cryoTEM automatized particle size distribution analysis can be used for both R&D and method validation services: https://lnkd.in/gWMreeCu
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🤔 Structure determination of proteins under ~100kDa with a Glacios? Totally possible! 🔬 Find out how at our webinar, July 17th 11am PST / 2pm EST, and hear from senior scientist Dr. Claudio Catalano about how the NIS team solved #HiTehA (~100 kDa) and #HSA (~60 kDa) on our #Glacios. 📝 Don't miss it: https://lnkd.in/gwMDthtW
📣 Cryo-EM structure determination of molecules smaller than 100 kDa has historically been challenging. 👨🔬 Join NIS Senior Scientist, Dr. Claudio Catalano, for a webinar "High-Resolution Structure Determination of Small Proteins by Cryo-EM Using a Glacios Microscope" July 17th, 11am PST / 2pm EST, demonstrating that routine cryo-EM structure determination is possible on smaller proteins. 🔬 In this webinar, you’ll hear about: - Obstacles in #cryoEM structure determination of small proteins. - Strategies for overcoming these obstacles. - Two case studies detailing the entire #structuredetermination process, #HiTehA, a ~100 kDa alpha-helical membrane protein, and #HSA, a ~60 kDa soluble protein. ✏ Register now: https://lnkd.in/gwMDthtW
This content isn’t available here
Access this content and more in the LinkedIn app
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💡 #Oncology research is making significant strides thanks to advancements in protein structure analysis techniques like cryo-EM. Used in conjunction with other analytical tools, like XRC, cryo-EM can provide additional insights into the interactions between molecules. 👨🔬 In a recent study, Nested Therapeutics leveraged cryo-EM to investigate their pan-RAF-MEK #molecularglue. While traditional inhibitors targeting the RAS-MAPK pathway have limitations, novel approaches like pan-RAF-MEK molecular glues offer the potential for more effective cancer therapies. 🔬 The use of #cryoEM helped validate the glue's binding to the target protein; revealing a clear density for their molecule within a specific site of MEK1. This finding strongly supports the glue's ability to engage with activated RAF signaling complexes, key drivers of cancer progression. 📑 Read the study now: https://lnkd.in/gGXapyCn
The pan-RAF-MEK non degrading molecular glue NST-628 is a potent and brain penetrant inhibitor of the RAS-MAPK pathway with activity across diverse RAS- and RAF-driven cancers - PubMed
pubmed.ncbi.nlm.nih.gov