Max Planck Institute of Immunobiology and Epigenetics

This is huge. 🎉 Nina Cabezas Wallscheid wins an #ERC #Consolidator #Grant. What a great achievement! Congratulations. ☄ It is already her second grant by the European Research Council (ERC) after being decorated with a Starting Grant in 2018. The new project #NutriSTEM investigates how metabolic products derived from food or produced by the body regulate hematopoietic stem cells. “We aim to assess the effects of widely consumed dietary components, such as caffeine or curcumin, on HSCs and the overall hematopoietic system,” says Nina Cabezas-Wallscheid. The ultimate aim is to identify the perfect diet plan for HSCs by studying how different metabolites influence their behavior and ageing. The results could not only change general dietary recommendations, but also open up new therapeutic ways of preventing leukemia and the effects of physiological ageing. You might wonder why this post comes so late after the official ERC announcement. Nina and her team are moving to Switzerland, and NutriSTEM is set to start at ETH Zürich/ Department of Health Sciences and Technology (D-HEST), ETH Zürich in 2025. Just recently, the Swiss State Secretariat for Education, Research and Innovation (SERI) decided to directly fund the NutriSTEM ERC Consolidator Grant as a transitional measure, since Switzerland had not been receiving funding from the European Commission until now. Congratulations, once again! 😎 Get all the details in our news piece: https://lnkd.in/en8TrRij

Next week, we welcome Laurel Raffington from the Max Planck Institute for Human Development in our lecture series. Laurel leads the "Biosocial - Biology, Social Disparities, and Development" research group at the MPIB in Berlin. Her noteworthy and frequently-cited studies on "Socioeconomic inequality in children's epigenetics" have made a significant impact in the field in recent years. Her research indicates that in children who grow up in socially disadvantaged families tend to have epigenetic profiles associated with poorer outcomes in adults. Yeah. Although it veers a bit from our usual research topics at the MPI-IE, we're extremely excited to delve into this interesting biosocial approach which intersects socio-#demographics with #epigenetics. A usual – guest are welcome to join!

💡 Research highlight from the Max Planck Yearbook! Do we really need both copies of the chromosomes we inherit from our mother and father? According to a fundamental principle in biology, nature does not act without a purpose. For certain genes, having one copy is actually sufficient. In these cases, the duplicate on the second chromosome can be silenced without having any impact on the organism. For other genes, however, a mutation or inactivation in just one of the two copies can trigger a serious disease. https://lnkd.in/e6b8YBb6 🔦 Background: The Max Planck Society annually publishes a scientific research report, digitally presented as a yearbook. This publication contains articles composed by varied research groups across all institutes, showcasing the diverse range of research undertaken in over 84 Max Planck Institutes. Out of these numerous reports, only a select few are highlighted and included in a refined print version. Among them is this year’s Highlight is a story by Maria Shvedunova, Meike Wiese, PhD and Asifa Akhtar. Their groundbreaking study uncovered a mechanism that safeguards the biallelic expression of haploinsufficient genes, shedding light on the importance of having two copies of each #chromosome & reveals a communication system between parental alleles but also points to potential therapeutic strategies for #diseases associated with haploinsufficient genes. Original Article in Nature Magazine: https://lnkd.in/euBD8WdB

❗ Friday Job Alert Posting. Currently, we have several positions in administration and service to fill. Especially check out our training positions for 2025 ✌ // Derzeit haben wir mehrere Stellen in der Verwaltung und im Service zu besetzen. Schauen Sie sich insbesondere unsere Ausbildungsplätze für 2025 an ✌. ➡ Anlagenmechaniker Sanitär-, Heizungs- und Klimatechnik (SHK) (m/w/d) 22. Juli 2024 - https://lnkd.in/e6fskj8W ➡ Betriebselektroniker mit Fachrichtung Energie- und Gebäudetechnik (m/w/d) 24. Juli 2024 – https://lnkd.in/evyDWzdS ➡ Hausmeister (m/w/d) 25. Juli 2024 – https://lnkd.in/eNbud-34 ➡ 2 Auszubildende zum Tierpfleger/in (m/w/d) Forschung & Klinik Start in 2025 – 31. Oktober 2024 – https://lnkd.in/eRyVQCx7 ➡ Auszubildende/n zur/zum Kauffrau/-mann für Büromanagement (m/w/d) Start in 2025 – 31. Oktober 2024 – https://lnkd.in/e7xnZCXQ https://lnkd.in/d_8Z_FBy #career #jobalert #jobsearch #maxplanck #research #germanyjobs #TVöD #publicsector

Finally! 🙌🏼We are now ready to share our print version of the Max Planck Institute of Immunobiology and Epigenetics's Gender Equality Plan🌈 with the Institute. A big thank you 🙏🏼 to everyone for all their hard work and efforts in the fight against gender inequalities💐- Marcus Rockoff Johanna Knipper Asifa Akhtar Ibrahim C. Nicola Iovino etc.etc. P.S. it was great to use the MPG #awareness cards for personal notes 😉Frauke Logermann

Use your chance now! 7th Max Planck Freiburg Epigenetics Meeting 📅 4 - 6 December 2024 🚩 Freiburg, Germany, MPI-IE 👥 Exciting line-up of 27 speakers covering the latest advances in #chromatin research & #epigenetics ⏰ Deadline: September 1st, 2024 Register now: https://lnkd.in/et_E4FBe

🤸♀️ Big news today! We are super excited to share this information. Nicola Iovino is the new Director at the MPI of Immunobiology and Epigenetics He will head the newly established department of Developmental Epigenetics. With this appointment, the Max Planck Society and the Max Planck Institute of Immunobiology and Epigenetics are deepening their expertise in the field of epigenetics. 😎 Nicola Iovino is an expert in the field of epigenetic inheritance. He and his team made significant contributions in recent years, most notably demonstrating that parents transmit not only genetic but also epigenetic information to their offspring in the form of histone post-translational modifications. »Epigenetic inheritance« has the potential to drive biological diversity and evolution. Contrary to the long-held belief that epigenetic information is erased during gamete formation, a growing evidence suggests that some epigenetic marks can be transferred across generations and control the first steps of the developing embryo. “We want unravel the impact of epigenetics on biological diversity and evolution by elucidating its influence on the expression of genes responsible for adaptive responses to environmental stimuli. I believe our findings will help shed light on novel principles underlying epigenetic inheritance,” says Nicola Iovino. Congratulations, Nicola! Learn more about the groundbreaking studies from the lab and the plans for the future of the new department in our news post: https://lnkd.in/gRKUH4wx #maxplanck #histone #epigenetics #development #evolution #inheritance #freiburg

🚨 New research & method (!) by the lab of Angelika Rambold. Using a new multispectral imaging and computational analysis approach called #OrgaPlexing, the Max Planck researcher illuminate how macrophages organize their intracellular structures during bacterial infections and inflammation. 🔬 OrgaPlexing The technique combines the simultaneous visualization of six key metabolic organelles during inflammatory response in primary macrophages. Through advanced 3D image analysis of organelle mass, their positioning and proximity, Julia Zimmermann et al could characterize the interactome of #mitochondria, lipid droplets, #peroxisomes, #lysosomes and the endoplasmic reticulum. “This simultaneous observation of interactions between multiple organelles, providing unprecedented insights into the intracellular control of cell metabolism and production of inflammatory molecules,” says Max Planck group leader Angelika Rambold. 🧩 The key finding OrgaPlexing showed: The macrophages form functional multi-organelle units that consist of the endoplasmic reticulum, mitochondria, lipid droplets, and peroxisomes. Together, they form and regulate a network of lipid flow paths, just like little highways for the production of lipid molecules within the cell, which are crucial for producing inflammatory molecules. Read more about this story here: 📚 Paper: https://lnkd.in/em_SMV-E 🔗 Press release: https://lnkd.in/eP8ZRWpQ 🔎 News & Views in Nature Cell Biology: “An organelle tango controls lipid metabolism” https://lnkd.in/e2EH3iTF

We couldn't be prouder! 😎 Our group leader Valerie Hilgers was appointed as the new Professor of Anatomy and Cell Biology in the Department of Biomedicine at University of Basel She will move with her lab to 🇨🇭 and continue her extremely successful research on alternative RNA processing in the nervous system. Here is the news: https://lnkd.in/e45vh2Eb Congratulations, Valérie! 🎉

#AlumniSuccess 🎉 We are happy that Ryo Morimoto recently started his own research lab at The Laboratory for Molecular Infection Medicine Sweden, MIMS. Ryo was a Project Leader in the lab of Max Planck Director Thomas Boehm and studied the evolutionary trajectory of the adaptive immune system in vertebrates. His newly established lab in Sweden will focus “on understanding host genome editing machinery in invertebrates –a pivotal element in fortifying immune functions against pathogens, demonstrating the fascinating evolutionary landscape of our immune systems.” Congratulations, Ryo! 👏 More details: https://lnkd.in/dFyBZ4jM The Laboratory for Molecular Infection Medicine Sweden, MIMS is the Swedish node in the Nordic EMBL Partnership for Molecular Medicine, and MIMS is hosted at Umeå University. #leader #groupleader #newPI #infection #lifescience #immunology