Today Circle Pharma achieved a major milestone! We filed our first Investigational New Drug application for our first-in-class oral cyclin A/B RxL inhibitor for the treatment of advanced solid tumors. #CancerResearch #Oncology #FDA #BreastCancerResearch #LungCancer #TNBC #BCHER Read more: https://lnkd.in/gjfhW8mX
Circle Pharma, Inc.
Biotechnology Research
South San Francisco, California 1,751 followers
A New Paradigm For Macrocycle Drug Development
About us
Circle Pharma initiated operations in June 2014 with seed funding from Pfizer, Inc. and Mission Bay Capital, LLP; we received additional seed funding from ShangPharma Investment Group Limited in November 2015. We recently raised Series B and Series C financing from The Column Group and NextTech Invest. We design and develop bioavailable macrocyclic peptide therapeutics against important clinical targets. We do this by applying a computational structure-based design approach that combines physics (conformational modeling), chemistry (innovative molecular components) and biology (protein target structure and function). We have selected intracellular protein-protein interactions that play key roles in cancer as the initial target group for our internal pipeline development. Circle is taking a new approach to the development of macrocylic peptide therapeutics that is based on the pioneering work of its founders to understand and computationally predict drug-like properties of macrocycles. Circle is advancing this understanding to design novel, inherently permeable macrocyclic peptide drug candidates against Circle’s internal targets and those of our collaboration partners. Our workflow includes the use of proprietary algorithms to design large, conformationally diverse, virtual libraries of cell permeable macrocyclic scaffolds that incorporate natural and non-natural backbone components. We deploy these virtual scaffold libraries in subsequent design steps that include the incorporation of functional side chains selected for both target binding and maintenance of permeability. Candidate compounds are synthesized and tested for both permeability and target affinity and the results are used to inform subsequent design cycles.
- Website
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https://www.circlepharma.com
External link for Circle Pharma, Inc.
- Industry
- Biotechnology Research
- Company size
- 11-50 employees
- Headquarters
- South San Francisco, California
- Type
- Privately Held
- Founded
- 2012
Locations
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Primary
681 Gateway Blvd
3rd Floor
South San Francisco, California 94080, US
Employees at Circle Pharma, Inc.
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Carlos Chavez
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Wajahat A. W
Business Operation Executive | IT Strategy | Leadership | Digital Transformation | Supply Chain
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James Evangelista
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Harry Loucks, MBA
Associate Director, FP&A @ Circle Pharma | Biotech/Life Sciences/Pharma | Trusted Data Analysis, Reporting and Insights that Support R&D, Commercial…