age1

On February 13th, Cradle successfully vitrified neural tissue and confirmed its electrical activity after cryopreservation. This week, they shared their breakthrough and ambition to make reversible human cryopreservation a reality — today, get the world's first inside look at Cradle on episode 47 of S³

Many patients won't live to see a cure to their disease. This is incredibly personal to me and my family. Through medical hibernation, by reversibly pausing the biological function of a patient, we could potentially extend the critical window of care for those without other treatment options. Incredibly excited for my cofounder age1 Laura Deming for the public launch of her new company Cradle backed with $48M, one of the most impressive team of scientists you will find, and a mission to pioneer reversible cryopreservation. For those of you who don't know Laura, she's dedicated her life to lassoing the future and yanking it closer to today for areas traditionally viewed as "icky" or as "backwater science". At 11 years old, she reached out to a pioneer in the aging field Prof. Cynthia Kenyon at UCSF to work in her lab studying worm aging. At 14 years old, she went to MIT to study physics. At 16 years old, she dropped out as a part of the first cohort of the Thiel Fellowship to build the predecessor fund to age1 and the first fund focused on aging, The Longevity Fund. This was at a time that the aging/longevity field was viewed as icky, irreproducible, and not worthy of significant resources or attention. There had only been a handful of biotech companies that had ever worked in this space. Today, longevity biotech is flourishing. Still a long ways to go, but remarkable progress in terms of bringing legitimate science and experienced biotech entrepreneurs to the field. Several years back, Laura saw reversible cryo as the next frontier. Like many scientists, I have always been fascinated by the potential of cryo but had a gut turning reaction when I heard the word cryonics. The likely reason comes down to lack of scientific progress, lack of legitimate work being done in the field to solve the problem of ice crystal damage to ensure reversibility, and its dystopian portrayal. The launch of Cradle is a monumental turning point for the field and the beginning of a critical emphasis on scientific progress towards reversible cryopreservation instead of the traditional field of cryonics that has historically sold hope without solving the problem of freezing and thawing without tissue damage. Read more here: https://lnkd.in/ghiQhVDc Careers page here to join and contribute to the very important mission: https://www.cradle.xyz/

Grateful to friend of the fund Vinod Khosla for joining me in a fireside chat at SynBioBeta. He showed up backstage, immediately asked me what I learned at the conference so far, suggested a spicy question for me to ask, and started asking me about the future. One of the greatest venture assistants aka VCs the planet has ever seen. No surprise that he’s been a first mover learning about and investing in some of the best companies in the longevity space. We’re lucky to share several portfolio companies with him such as Loyal / Cellular Longevity working on developing drugs to help dogs live longer and healthier as well as Rubedo Life Sciences developing therapies to target pathogenic cells that drive aging. The future is going to be amazing thanks to biology loving optimists like Vinod who also appreciate the importance of empathy.

we've raised another $45M, led by Bain Capital Ventures, bringing total $ raised since I started Loyal 4.5 years ago to $125M This new $ fuels us to very hopefully! bring the first FDA-approved lifespan extension drug to market in 2025. We have the data, the team, and the path forward — this capital was the last puzzle piece to ensure that, if our vision is possible, we will achieve it. new investors: Bain Cap and Valor Equity Partners with existing investors doubling/tripling down including: Khosla, First Round Capital, Box Group, Quiet Capital, Collaborative Fund, Todd & Rahul, + more Raising a growth round post-ZIRP as a weird company was a great learning experience + I plan to write that up sometime soon. the tl;dr - was crucial to connect use of new capital --> milestones unlocked --> objective increase in company, value *even* in a tough market We are now running on: > earning FDA mfg, safety, + RXE approval for LOY-002 (senior dog lifespan extension) > LOY-002 market launch in 2025 > building out distribution + commercial functions for nationwide supply > cont'd development of LOY-001 (injectable) and LOY-003 (daily pill) for large dog lifespan ext Thanks WSJ for covering!

Huge day for dogs (and eventually people) everywhere 🎉🎉 Celine Halioua is a rockstar.

How do we move from lab to clinic for an aging intervention in *this* decade? I spent a lot of time thinking about this question and created a framework dubbed the longevity funnel framework (LFF) to answer it. Read the deep dive here: https://lnkd.in/g-9mU-RP

Today at the inaugural Toronto Aging Biology Symposium, BioAge CEO Kristen Fortney will join our friend Alex Colville, General Partner at age1, to highlight their journeys into longevity biotech and the insights they’ve gained along the way. It’s a homecoming of sorts for Kristen, who earned her PhD in Bioinformatics at the University of Toronto! BioAge is proud to sponsor TABS, which brings together internationally recognized leaders and scientists to cover topics on longevity research, clinical translation, startups and VC. The event is organized by the Toronto Longevity Research Circle, a student-led initiative building community for longevity in the region by connecting students interested in aging biology and inspiring interest in students working in related fields. https://tlrc.bio

A new career highlight last night - the drug that I am working on for Loyal was mentioned in Lee Sung Jin’s acceptance speech at the Emmy’s

Congratulations to Mark Boettger MD, FACEP and Ryan Sprenger for being awarded a NASA - National Aeronautics and Space Administration Innovative Advanced Concepts (NIAC) grant to test the potential of hibernation to protect astronauts from the damaging effects of space travel!  This award validates the broad applicability of Fauna’s approach to improving human health, aligning with our dedication to metabolic research and skeletal muscle preservation  as we dive deeper into novel mechanisms for obesity. Stay tuned for a blog post to explain the larger implications of this work for human health on the Fauna Bio website! https://lnkd.in/gRQYmw7w #hibernation in #space  #muscleloss #biotech