User profiles for Rachana Haliyur
 | Rachana Haliyur, MD, PhDUniversity of Michigan Kellogg Eye Center Verified email at med.umich.edu Cited by 1437 |
Microglia are essential to masculinization of brain and behavior
Brain sexual differentiation in rodents results from the perinatal testicular androgen surge. In
the preoptic area (POA), estradiol aromatized from testosterone upregulates the production …
the preoptic area (POA), estradiol aromatized from testosterone upregulates the production …
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance
of T cells. This could suppress autoimmunity in those at risk for the development of T1D, as …
of T cells. This could suppress autoimmunity in those at risk for the development of T1D, as …
[HTML][HTML] Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks
Using an integrated approach to characterize the pancreatic tissue and isolated islets from
a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β …
a 33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β …
[HTML][HTML] α cell function and gene expression are compromised in type 1 diabetes
Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of
C-peptide long after disease onset but develop an inadequate glucagon response to …
C-peptide long after disease onset but develop an inadequate glucagon response to …
HLA class II antigen processing and presentation pathway components demonstrated by transcriptome and protein analyses of islet β-cells from donors with type 1�…
Type 1 diabetes studies consistently generate data showing islet β-cell dysfunction and T
cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated …
cell–mediated anti-β-cell–specific autoimmunity. To explore the pathogenesis, we interrogated …
[HTML][HTML] Modeling monogenic diabetes using human ESCs reveals developmental and metabolic deficiencies caused by mutations in HNF1A
Human monogenic diabetes, caused by mutations in genes involved in beta cell development
and function, has been a challenge to study because multiple mouse models have not …
and function, has been a challenge to study because multiple mouse models have not …
[HTML][HTML] Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells
Pancreatic islets secrete insulin from β cells and glucagon from α cells, and dysregulated
secretion of these hormones is a central component of diabetes. Thus, an improved …
secretion of these hormones is a central component of diabetes. Thus, an improved …
[HTML][HTML] Demographic and metabolic risk factors associated with development of diabetic macular edema among persons with diabetes mellitus
Purpose Diabetic macular edema (DME), a leading cause of visual impairment, can occur
regardless of diabetic retinopathy (DR) stage. Poor metabolic control is hypothesized to …
regardless of diabetic retinopathy (DR) stage. Poor metabolic control is hypothesized to …
[HTML][HTML] Combinatorial transcription factor profiles predict mature and functional human islet α and β cells
Islet-enriched transcription factors (TFs) exert broad control over cellular processes in pancreatic
α and β cells, and changes in their expression are associated with developmental state …
α and β cells, and changes in their expression are associated with developmental state …
[HTML][HTML] Liquid biopsy for proliferative diabetic retinopathy: single-cell transcriptomics of human vitreous reveals inflammatory T cell signature
Purpose Current therapies for proliferative diabetic retinopathy (PDR) do not specifically
target VEGF-independent, cell-type specific processes that lead to vision loss, such as …
target VEGF-independent, cell-type specific processes that lead to vision loss, such as …