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Review
. 2009 May;55(5):605-10.
doi: 10.1016/j.yhbeh.2009.03.008.

The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system

Nancy G Forger  1
Affiliations
Review

The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system

Nancy G Forger. Horm Behav. 2009 May.

Abstract

In honor of the 50th anniversary of the "organizational hypothesis," this paper reviews work on sexual differentiation of the spinal cord and peripheral nervous system. Topics considered include the spinal nucleus of the bulbocavernosus, the ejaculation center, the cremaster nucleus, sensory and autonomic neurons, and pain. These relatively simple neural systems offer ample confirmation that early exposure to testicular hormones masculinizes the nervous system, including final common pathways. However, I also discuss findings that challenge, or at least stretch, the organizational hypothesis, with important implications for understanding sex differences throughout the nervous system.

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References

    1. Barthold JS, Mahler HR, Newton BW. Lack of feminization of the cremaster nucleus in cryptorchid androgen insensitive rats. J Urol. 1994;152:2280–2286. - PubMed
    1. Barthold JS, Mahler HR, Sziszak TJ, Newton BW. Lack of feminization of the cremaster nucleus by prenatal flutamide administration in the rat and pig. J Urol. 1996;156:767–771. - PubMed
    1. Beach FA, Holz AM. Mating behavior in male rats castrated at various ages and injected with androgen. J Exper Zool. 1946;101:91–142. - PubMed
    1. Beach FA, Noble RG, Orndoff RK. Effects of perinatal androgen treatment on responses of male rats to gonadal hormones in adulthood. J Comp Physiol Psych. 1969;68:490–497. - PubMed
    1. Borzan J, Fuchs PN. Organizational and activational effects of testosterone on carrageenan-induced inflammatory pain and morphine analgesia. Neurosci. 2006;143:885–893. - PubMed

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