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Licensed Unlicensed Requires Authentication Published by De Gruyter November 27, 2015

Endocrine and metabolic adaptations to pregnancy; impact of obesity

  • Sylvie Hauguel-de Mouzon EMAIL logo and Luciana Lassance

Abstract

Adaptations of maternal endocrine and metabolic homeostasis are central to successful pregnancy. They insure that an adequate and continuous supply of metabolic fuels is available for the growing fetus. Healthy pregnancy is classically described as a mild diabetogenic state with significant adjustments in both insulin production and sensitivity. The placenta contributes to the endocrine adaptations to pregnancy through the synthesis of various hormones which may impact insulin action. Obesity has the highest prevalence among metabolic disease in pregnancy. This article summarizes the literature addressing the endocrine and metabolic adaptations implemented during normal pregnancy. Mechanisms of regulation are further examined in the context of maternal obesity.


Corresponding author: Sylvie Hauguel-de Mouzon, Center for Reproductive Health, Department Obstetrics and Gynecology, MetroHealth Medical Center/Case Western Reserve University, Cleveland, OH, USA, Phone: +(216) 778-4262, Fax: +(216) 778-1534, E-mail:

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Received: 2015-9-4
Accepted: 2015-10-19
Published Online: 2015-11-27
Published in Print: 2015-10-1

©2015 by De Gruyter

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