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Meta-Analysis
. 2020 May;113(5):185-192.
doi: 10.1177/0141076820918236.

Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework

Sam Hodgson  1 , Isabella Watts  2 , Simon Fraser  1 , Paul Roderick  1 , Hajira Dambha-Miller  1
Affiliations
Meta-Analysis

Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework

Sam Hodgson et al. J R Soc Med. 2020 May.

Abstract

To conduct a systematic review and develop a conceptual framework on the mechanisms linking loneliness, social isolation, health outcomes and mortality. Electronic databases were systematically searched (PubMed, MEDLINE, Scopus and EMBASE) from inception to October 2018 followed by manual searching to identify research on loneliness, social isolation and mortality in adults published in the English language. Articles were assessed for quality and synthesised into a conceptual framework using meta-ethnographical approaches. A total of 122 articles were included. These collated observational designs examining mediators and moderations of the association in addition to qualitative studies exploring potential mechanisms were included. A framework incorporating 18 discrete factors implicated in the association between loneliness, social isolation and mortality was developed. Factors were categorised into societal or individual, and sub-categorised into biological, behavioural and psychological. These findings emphasise the complex multidirectional relationship between loneliness, social isolation and mortality. Our conceptual framework may allow development of more holistic interventions, targeting many of the interdependent factors that contribute to poor outcomes for lonely and socially isolated people.

Keywords: Social conditions and disease; health policy; health promotion; qualitative research.

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Figures

Figure 1.
Figure 1.
Flow diagram demonstrating number of research articles identified in searches, screened, assessed for eligibility, included in data synthesis, and excluded, in line with PRISMA guidelines.
Figure 2.
Figure 2.
Conceptual framework demonstrating mechanisms underlying associations between loneliness, social isolation, cardiovascular disease and mortality. The outer coloured layer represents loneliness and social isolation; their interaction and interdependence is demonstrated with bi-directional arrows. Factors implicated in the association between loneliness, social isolation, cardiovascular disease and mortality were grouped into ‘psychological,’ ‘behavioural,’ ‘sociological’ and ‘physiological’. The associations between these categories, cardiovascular disease, mortality, loneliness and social isolation are demonstrated through bi-directional arrows. Outside the coloured layer, the broader impact of loneliness and social isolation on wider society and its reciprocal relationship is demonstrated under the ‘societal’ category.
See this image and copyright information in PMC

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References

    1. Courtin E, Knapp M. Social isolation, loneliness and health in old age: a scoping review. Health Soc Care Community 2017; 25: 799–812. - PubMed
    1. Holt-Lunstad J, Smith TB, Baker M, Harris T, Stephenson D. Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci 2015; 10: 227–237. - PubMed
    1. Hawkley LC, Cacioppo JT. Loneliness matters: a theoretical and empirical review of consequences and mechanisms. Ann Behav Med 2010; 40: 218–227. - PMC - PubMed
    1. McPherson M, Smith-Lovin L, Brashears ME. Social isolation in America: changes in core discussion networks over two decades. Am Sociol Rev 2006; 71: 353–375.
    1. Office for National Statistics. Loneliness – what characteristics and circumstances are associated with feeling lonely? See https://www.ons.gov.uk/peoplepopulationandcommunity/wellbeing/articles/l... (last checked 18 December 2019).