Summary of signs and symptoms of monkeypox infection in a London 2022 cohort compared with previous reports from the Democratic Republic of the Congo in 2007-11 and Nigeria in 2017-18
| London 2022 (n=197) | Democratic Republic of the Congo 2007-11 (n=216)10 | Nigeria 2017-18 (n=122)22 | |
|---|---|---|---|
| Features | |||
| Lesions (ordered by frequency) | Macular, papular, vesicular, pustular, umbilicated, scabbed, crusted, widespread maculopapular (see supplementary figure 2) | Macular, papular, vesicular, pustular, umbilicated, scabbed | Vesiculopustular |
| Mean count at presentation | 6* | 370 | NA |
| Progression | Lesions present at different stages simultaneously. Not all lesions progressed from one phase to another in order | Progression from one phase to another occurs in order | NA |
| Distribution (most common) | Genitals (56.4%), perianal (41.6%) | Head, arms | Face (96% of 71), leg (91% of 69), trunk (80% of 70) |
| Symptoms | |||
| Systemic (most common) | Fever (61.9%), lymphadenopathy (57.9%), myalgia (31.5%) | Malaise (85.2%), lymphadenopathy (57.4%), fever/chills (45.3%), sweats (19.9%) | Fever (88%), headache (79%), lymphadenopathy (69%), myalgia (63%) |
| Localised (most common) | Rectal pain (36.0%), sore throat (16.8%), penile oedema (15.7%) | Sore throat (78.2%), nasal discharge/congestion (31.0%) | Sore throat (58%) |
NA=not available.
* Lesion count displayed as mean to allow comparison with previous data.