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2021, Academia Letters
Circulation: Arrhythmia and Electrophysiology
Brugada Syndrome Phenotype Elimination by Epicardial Substrate Ablation2015 •
Background— Whether Brugada syndrome (BrS) depends on functional epicardial substrates, which may be definitively eliminated by radiofrequency ablation, remains unknown. Methods and Results— Patients with BrS underwent epicardial mapping to identify areas of abnormal electrograms as target for radiofrequency ablation. Substrate identification consisted in mapping right ventricle epicardial surface before and after flecainide (2 mg/kg per 10 minutes). After radiofrequency ablation, flecainide and remap confirmed elimination of abnormal substrate, BrS ECG pattern, and ventricular tachycardia/ventricular fibrillation inducibility. Flecainide testing was performed at each follow-up visits ≤6 months. Fourteen patients with BrS, median age 39 years (30.3–42.3) with implantable cardioverter–defibrillator were enrolled. Low-voltage areas (<1.5 mV) were commonly identified on the anterior right free wall and right ventricular outflow tract, which increased after flecainide from 17.6 cm 2 ...
2011 •
Background— The underlying electrophysiological mechanism that causes an abnormal ECG pattern and ventricular tachycardia/ventricular fibrillation (V t /VF) in patients with the Brugada syndrome (BrS) remains unelucidated. However, several studies have indicated that the right ventricular outflow tract (RVOT) is likely to be the site of electrophysiological substrate. We hypothesized that in patients with BrS who have frequent recurrent VF episodes, the substrate site is the RVOT, either over the epicardium or endocardium; abnormal electrograms would be identified at this location, which would serve as the target site for catheter ablation. Methods and Results— We studied 9 symptomatic patients with the BrS (all men; median age 38 years) who had recurrent VF episodes (median 4 episodes) per month, necessitating implantable cardioverter defibrillator discharge. Electroanatomic mapping of the right ventricle, both endocardially and epicardially, and epicardial mapping of the left vent...
Circulation: Arrhythmia and Electrophysiology
Endocardial Ablation Approach for Brugada Syndrome2018 •
2011 •
Circulation: Arrhythmia and Electrophysiology
Efficacy of Endocardial Ablation of Drug-Resistant Ventricular Fibrillation in Brugada SyndromeJournal of Clinical and Experimental Research in Cardiology
Endocardial Approach for Substrate Ablation in Brugada Syndrome: Epicardial, Endocardial or Transmural Substrate?2018 •
Circulation: Arrhythmia and Electrophysiology
Epicardial Substrate Ablation in Brugada Syndrome2015 •
JACC: Clinical Electrophysiology
Mechanisms Underlying Epicardial Radiofrequency Ablation to Suppress Arrhythmogenesis in Experimental Models of Brugada Syndrome2017 •
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Journal of Interventional Cardiac Electrophysiology
Radiofrequency Ablation of Ventricular Fibrillation and Multiple Right and Left Atrial Tachycardia in a Patient with Brugada Syndrome2004 •
HeartRhythm Case Reports
Successful endocardial catheter ablation of a drug-resistant monomorphic ventricular tachycardia in a child with Brugada syndrome2020 •
2017 •
Acta Cardiologica Sinica
Safety and Efficacy of Epicardial Ablation of Ventricular Tachyarrhythmias: Experience from a Tertiary Referral Center in Taiwan2018 •
Circulation
Mapping and Ablation of Ventricular Fibrillation Associated With Long-QT and Brugada Syndromes2003 •
Pacing and Clinical Electrophysiology
The Brugada Syndrome: Is an Implantable Cardioverter Defibrillator the Only Therapeutic Option?2002 •
2013 •
Innovations (Philadelphia, Pa.)
Strategies to Improve the Efficacy of Epicardial Linear Ablation on the Beating Heart2018 •
2000 •
2009 •
2011 •
Arrhythmia & Electrophysiology Review
Brugada Syndrome: Progress in Genetics, Risk Stratification and Management2019 •
Journal of the American College of Cardiology
Epicardial Ventricular Tachycardia Ablation2010 •
2005 •
2014 •
2007 •
2011 •
Cardiovascular Journal
Ventricular Fibrillation with Brugada Syndrome: A Case Report2015 •
Revista Española de Cardiología (English Edition)
Epicardial ablation of ventricular tachycardia via the aortic cusps in ischemic cardiomyopathy2020 •