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We have several data sets to choose from to support your project. The data sets are defined below and can be chosen during the application process. Click here to skip to the resource applications.

Our resource request applications are for anyone who wants to use a WRAP resource or write a grant proposing the use of WRAP resources. Before you begin, contact the WRAP study team to consult about the initial concept approval and feasibility.

We have the following data to offer:

These data sets are available for all or the majority of the WRAP participants:

WRAP clinical, cognitive and survey data – Data snapshots (“freezes”) taken semiannually, with data lock dates in May and November. Contains a wide variety of measures of cognition, clinical status, general health (self-report and laboratory), and limited social and behavioral factors. View the WRAP Freeze Data Dictionary
Data derived from plasma – Datasets comprising a variety of core AD biomarkers in plasma from several different laboratories, including multiple isoforms of amyloid and phosphorylated tau as well as markers of neurodegeneration and gliosis. For methodological details, click here to view the README file for each dataset.
Metabolomic data – The dataset includes longitudinal metabolomics from both plasma and CSF generated by Metabolon.
Genomics – Genome-wide array (GWAS) using the Illumina Expanded Multi-Ethnic Genotyping Array (MEGAex)
Genomics – Whole-genome sequencing can be applied for through the Alzheimer’s Disease Sequencing Project

These data sets are available for a sub-set of the WRAP participants. The data in these sub-sets are not necessarily time-linked to the main WRAP study visit:

Data derived from Cerebrospinal fluid (CSF) – Datasets comprising a variety of analytes including core AD measures and some experimental markers. In general, caution should be exercised when combining assays from different files into a single analysis, as these represent distinct batches analyzed with different equipment in different labs. Click HERE for the README file.
Magnetic resonance imaging (MRI) – Volumetric measures relevant for computing global and hippocampal atrophy1, as well as vascular injury2 (white matter hyperintensities). This dataset includes:
T1
T2
FLAIR
These are in NIfTI format. Derived values are in tsv format.[1] Allison SL, Koscik RL, Cary RP, Jonaitis EM, Rowley HA, Chin NA, Zetterberg H, Blennow K, Carlsson CM, Asthana S, Bendlin BB, Johnson SC. Comparison of different MRI-based morphometric estimates for defining neurodegeneration across the Alzheimer’s disease continuum. NeuroImage: Clinical. 2019 Jan 1;23:101895. PMCID: PMC6599872[2] Schmidt P, Gaser C, Arsic M, Buck D, Förschler A, Berthele A, Hoshi M, Ilg R, Schmid VJ, Zimmer C, Hemmer B, Mühlau M. An automated tool for detection of FLAIR-hyperintense white-matter lesions in Multiple Sclerosis. NeuroImage. 2012 Feb 15;59(4):3774–3783. PMID: 22119648
Positron emission tomography imaging (PET) –Derived values summarizing amyloid (PiB) and tau (MK6240/florquinitau) tracer uptake in regions of interest. These data include: T1 and PET data are in NIfTI format. Derived values are in tsv format.

In order to facilitate the request process, the following are statistics compiled from the WRAP cohort:

WRAP Statistics

-Derived from 11/30/2023 data freeze

Cohort Demographics and Cognitive Summary

Main Study Visit and Cognitive Status Summary

Statistic	Value
Avg age at 1st cognitive assessments	54.76
StdDev age at 1st cognitive assessments	7.02
Avg age at last cognitive assessments	66.21
StdDev age at last cognitive assessments	8.89
Avg years of cognitive follow ups	11.45
Avg count of cognitive follow ups	4.70
Baseline diagnosis Normal	1,672.00
Baseline diagnosis Dementia	0.00
Baseline diagnosis MCI	12.00
Baseline diagnosis Impaired-Other	23.00
Last (within freeze) diagnosis Normal	1,556.00
Last (within freeze) diagnosis Dementia	28.00
Last (within freeze) diagnosis MCI	87.00
Last (within freeze) diagnosis Impaired-Other	25.00

Primary Race

primary race	count
American Indian or Alaska Native	0
Asian	2
Black or African American	205
White	1,451
Unknown	49
Other	0

Participants with Hispanic Heritage

hispanic people	count
Yes	38
No	1,666
Unknown	19

Sex

sex	count
M	511
F	1,203
null	8

Education

years of education	count
None	0
1-5 (<= grade school)	0
6-8 (<= middle school)	1
9-12 (<= high school)	193
13-14 (<= associates)	533
15-16 (<= bachelors)	332
17-18 (<= masters)	530
19+ (<= phd)	109
missing_999	25

APOE

apoe combo	count
2/2	7
2/3	135
2/4	55
3/3	850
3/4	527
4/4	76
Null/Null	72

Multimodal Biomarker Counts

Statistic	count
Number of people with LP	370
Number of people with MRI	753
Number of people with Amyloid PET	521
Number of people with Tau PET	554
Number of people with LP & MRI	328
Number of people with LP & Amyloid PET	265
Number of people with LP & Tau PET	282
Number of people with MRI & Amyloid PET	511
Number of people with MRI & Tau PET	540
Number of people with Amyloid PET & Tau PET	511
Number of people with LP & MRI & Amyloid PET	261
Number of people with LP & MRI & Tau PET	275
Number of people with LP & Amyloid PET & Tau PET	261
Number of people with MRI & Amyloid PET & Tau PET	501
Number of people with LP & MRI & Amyloid PET & Tau PET	257

Summary statistics for participants with MRI

WRAP MRI

Number of MRI Assessments	Number of Participants	Avg Yrs Between Assessments	Avg Yrs of Assessments
>= 1	753	1.98	4.60
>= 2	511	2.92	6.78
>= 3	309	2.90	9.29
>= 4	227	2.67	10.09
>= 5	120	2.12	10.30
>= 6	74	1.90	10.55

Demographic and Cognitive Summary

Statistic	Value
Avg age at 1st cognitive assessments	54
StdDev age at 1st cognitive assessments	7
Avg age at last cognitive assessments	68
StdDev age at last cognitive assessments	7
Avg years of cognitive follow ups	13
Avg count of cognitive follow ups	5
Baseline diagnosis Normal	743
Baseline diagnosis Dementia	0
Baseline diagnosis MCI	6
Baseline diagnosis Impaired-Other	4
Last (within freeze) diagnosis Normal	688
Last (within freeze) diagnosis Dementia	13
Last (within freeze) diagnosis MCI	42
Last (within freeze) diagnosis Impaired-Other	8

Summary statistics for participants with LP

Number of LP Assessments	Number of Participants	Avg Yrs Between Assessments	Avg Yrs of Assessments
>= 1	370	1.71	3.73
>= 2	220	2.87	6.27
>= 3	134	2.74	8.33
>= 4	85	2.57	9.64
>= 5	46	2.43	10.85
>= 6	22	2.26	11.37

Demographic and Cognitive Summary

Statistic	Value
Avg age at 1st cognitive assessments	54
StdDev age at 1st cognitive assessments	6
Avg age at last cognitive assessments	69
StdDev age at last cognitive assessments	7
Avg years of cognitive follow ups	14
Avg count of cognitive follow ups	6
Baseline diagnosis Normal	367
Baseline diagnosis Dementia	0
Baseline diagnosis MCI	3
Baseline diagnosis Impaired-Other	0
Last (within freeze) diagnosis Normal	331
Last (within freeze) diagnosis Dementia	7
Last (within freeze) diagnosis MCI	28
Last (within freeze) diagnosis Impaired-Other	2

Summary statistics for participants with Amyloid PET

Number of Amyloid PET Assessments	Number of Participants	Avg Yrs Between Assessments	Avg Yrs of Assessments
>= 1	554	1.68	3.26
>= 2	315	2.96	5.74
>= 3	144	3.34	9.42
>= 4	113	3.07	9.61
>= 5	15	2.37	10.22
>= 6	4	2.18	11.43

Demographic and Cognitive Summary

Statistic	Value
Avg age at 1st cognitive assessments	54.72
StdDev age at 1st cognitive assessments	7.15
Avg age at last cognitive assessments	69.25
StdDev age at last cognitive assessments	7.25
Avg years of cognitive follow ups	14.54
Avg count of cognitive follow ups	6.06
Baseline diagnosis Normal	515.00
Baseline diagnosis Dementia	0.00
Baseline diagnosis MCI	4.00
Baseline diagnosis Impaired-Other	2.00
Last (within freeze) diagnosis Normal	474.00
Last (within freeze) diagnosis Dementia	9.00
Last (within freeze) diagnosis MCI	33.00
Last (within freeze) diagnosis Impaired-Other	4.00

Summary statistics for participants with Tau PET

Number of Tau PET Assessments	Number of Participants	Avg Yrs Between Assessments	Avg Yrs of Assessments
>= 1	521	1.20	1.25
>= 2	251	2.50	2.59
>= 3	10	2.05	4.28
>= 4	1	1.79	5.38
>= 5	0	0.00	0.00
>= 6	0	0.00	0.00

Demographic and Cognitive Summary

Statistic	Value
Avg age at 1st cognitive assessments	54
StdDev age at 1st cognitive assessments	7
Avg age at last cognitive assessments	69
StdDev age at last cognitive assessments	7
Avg years of cognitive follow ups	14
Avg count of cognitive follow ups	6
Baseline diagnosis Normal	548
Baseline diagnosis Dementia	0
Baseline diagnosis MCI	4
Baseline diagnosis Impaired-Other	2
Last (within freeze) diagnosis Normal	500
Last (within freeze) diagnosis Dementia	12
Last (within freeze) diagnosis MCI	37
Last (within freeze) diagnosis Impaired-Other	4

Resource Applications

WRAP Application for Resources

For scientists interested in WRAP resources.*

Wisconsin ADRC Application for Resources

For scientists interested in Wisconsin Alzheimer’s Disease Research Center (ADRC) resources.

UP Application for Resources

For internal candidates requesting data or images for a project originating within Wisconsin ADRC or WRAP.**

*For WRAP Applications: Your data request will be taken in consideration by the WRAP Science Executive Committee. You will be notified within 4-6 weeks regarding the status of your application.

**For UP Applications: Your resource request(s) will be taken into consideration by the applicable Science Executive Committee. You will be notified within 4 to 6 weeks regarding the status of your application. The Committee will not provide a written evaluation of proposals. A letter indicating the Committee’s decision to support or not support the proposed request will be provided to the applicant, along with any special instructions and/or requirements that must be met before resources will be released.