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DEBRA UK
🔬 Research blog: Laying the groundwork for a permanent genetic fix for RDEB 🔬 Meet our researcher, Dr Carina Graham, from King's College London. She is working on Dr Joanna Jacków's project, to replace the broken collagen gene using a new form of gene replacement therapy to create a permanent treatment for RDEB. "A topically applied DNA editing treatment would be enormously beneficial to all types of EB and all kinds of inherited skin diseases. It sounds like science fiction, but we hope to be among the first researchers to make it a reality!" Read Dr Graham's blog! 👇
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John Gordon
#Senescence | Not just for Oldies 👴 | OPEN ACCESS 'Perspective' by Joao Pedro de Magalhaes | Online Science Magazine | University of Birmingham | Functions of senescent cells: Recent evidence from mice and other model organisms has revealed that cellular senescence is important during the development of several tissues and organs, tissue regeneration in several animals, inflammation and wound healing, tumor suppression, insulin secretion in pancreatic beta cells, and has structural roles in the vascular system and placenta. There can be different types of senescent cells, which have a senescence-associated secretory phenotype (SASP), and are associated with the expression of markers such as p16 and p21.
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Leukaemia UK
Leukemic stem cells (LSCs) are sneaky. They manage to lie low during treatment and then spring back to life later on, causing a relapse. But how is this even possible?! 🤯 In our latest blog, we unpack a study from a team of scientists (including three of our funded researchers), which explores how LSC’s in a subtype of acute myeloid leukaemia (AML) restart their growth. The findings are fascinating - and dangerous. But unravelling these mysteries is key to unlocking more effective treatments and therapies, and ultimately stopping leukaemia in its tracks. 🗝️ Another stark reminder of the importance of continued support and funding for leukaemia research. Read our blog to discover the secret of these crafty cells. 👇 https://lnkd.in/eaeuzm9W
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BioDesign
🎧Podcast your way into Biodesign 🎧 We have chosen our top three pods to bring you into the world of biology inspired solutions for those times you would prefer to, listen than read or just want something new for your commute, walk or blocking out those annoying colleagues (just kidding!) 1️⃣For science lovers: The Grow Everything Biotech Podcast 🥼Each episode delves into a conversation with an influential guest, about biological solutions that more often than not originate from a mission of creating a sustainable angle to their chosen industry. A great pod for those that want a wider understanding of the solutions biology has to offer. https://lnkd.in/efQC9n82 2️⃣For the practical one: The Circular Economy show ⚙️The Ellen MacArthur Foundation podcasts bring societal and cultural influences into the conversation. This is a the pod for a broader outlook on sustainable solutions and how they can be integrated into a circular economy. https://lnkd.in/eaaJ3px6 3️⃣For the one that wears all the hats: The Inside Track 🧢The new podcast from SynBioBeta is a definite listen for those more into the nitty gritty of science, technology and industry. So far the series has explored various ways in which biotechnology is shaping the future through architecture, carbon-capture as well as branching into how blockchain can restructure scientific publishing https://lnkd.in/e9d_DNqd 🎧If you have a go to pod, share it in the comments!
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Queen Mary Faculty of Medicine and Dentistry
The wonderful thing about #research is that you never know where it will take you... A technique developed by Dr Benjamin Werner from Barts Cancer Institute (Queen Mary University of London) to understand the evolutionary processes affecting the genome of cancer tumours has been used to provide an accurate age for a patch of seagrass. The grass, which is now known to be over 1400 years old, is a clonal species which can spread by producing genetically identical copies of itself. It has been historically difficult to get an accurate age for these types of species, especially when the original plant no longer exists. Using a methodology based on Dr Werner’s model, which was developed as part of ground-breaking research into somatic evolution at Barts Cancer Institute, an international team were able to precisely determine the age of a patch of seagrass from the Baltic. It is hoped that this method will be similarly successful in aging other clone species. You can read more about this research in the journal Nature, Ecology and Evolution - find the link in the comments, below.
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Agustín Oyhamburú Pantano
Unlock Your Research Legacy! 🗝️ Ever wondered how to publish your historic structures or thesis data? We've got the solution! Whether you have electronic CIFs or just hardcopy data, our team can help you share your valuable research through the CSD. Discover how to make your work accessible to the world: Read the full blog post Let's make your data part of scientific history! 🌟📚 #Research #ScienceSharing #DataPublication
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Historic Environment Scotland
There were once around 4,000 building stone quarries in Scotland – so how can you tell where one piece came from? And is it possible to figure out whether one small fragment was once part of a larger, very famous whole – like the Stone of Destiny, perhaps? Enter our intrepid science team! Stone matching is a skill that we use all the time at HES to help preserve and maintain different types of stone buildings across the country. We start by getting a physical sample which is taken to our science lab at the Engine Shed for analysis. Techniques the team use include X-ray fluorescence analysis (also used in authenticating fine art!), scanning electron microscopy, colour analysis and more. This means we were in a perfect position to help when the Commissioners for the Safeguarding of the Regalia asked us to determine whether an unassuming chunk of sandstone was the real deal. Spoilers – the answer was yes. #HeritageScience #STEM #Science #ScottishHistory #geology #Digital #HeritageMatters #StoneOfDestiny
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Pedro Castanheira
"rise of drug-resistant superbugs could make the Covid pandemic look "minor"" Very strong words by Prof. Dame Sally Davies, the UK's special envoy for AMR. One way is to find alternatives to antibiotics, such as the ones we are developing at IMMUNETHEP, namely vaccines and monoclonal antibodies to prevent and treat bacterial infections. In our vision, those alternatives might help to decrease antibiotic usage, slowing down the development and spreading of AMR, and ultimately extending the lifetime of the few effective antibiotics we have left... ... for a safer tomorrow! #immunethep #vaccines #AMR #antimicrobial #bacteria
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Quadram Institute
Using microbiome sequencing to reduce food spoilage in ready to eat ham🧬 Sometimes ready to eat ham can show green discolouration. At the moment we don’t know why this occasionally happens or the microbes responsible for the change of colour in ham 🤔 Researchers are working with industry to use metagenomics, a process for identifying a range of microbes, to understand why this happens and to help reduce spoilage in the future. The project is funded through the UK Food Safety Research Network, which is based here at the Quadram Institute and connects food industry, food and health policymakers and academia to collaboratively pursue shared research priorities to protect us from microbial foodborne hazards 🛡️ Read more➡️ https://buff.ly/4bCH9DV #UKFRSN #FoodSafety #Microbiome #ReadyToEat
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Vault Bioventures
A UK biotech group has raised £48 million to support Alzheimer's research, marking a significant boost for the battle against this widespread and costly disease. Takeaways - ▪️ Accelerated Research - The funding supports crucial studies on neuron structure, synaptic transmission, and astrocytes, potentially leading to new Alzheimer's treatments. ▪️ Economic Impact - Successful research could reduce healthcare costs, while also driving job creation and industry growth. Discussion Points - ▪️ What breakthroughs might emerge from this funding? ▪️ How could these advancements change the landscape of Alzheimer's care and support families affected by the disease?
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Emma P.
📍 Pioneering gene therapy restores UK girl's hearing A UK girl born deaf can now hear unaided, after a groundbreaking gene-therapy treatment. Given as an infusion into the ear, the therapy replaces faulty DNA causing her type of inherited deafness. Medics at Addenbrooke's Hospital in Cambridge have used gene therapy to help a rare condition, auditory neuropathy. It's caused by the disruption of nerve impulses travelling from the inner ear to the brain. Opal Sandy can now respond to her parents's voices and can communicate with words such as "Dada" and "bye-bye". The therapy uses a modified, harmless virus to deliver a working copy of the Otof gene into these cells. Opal had the therapy in her right ear, under general anaesthetic, and a cochlear implant put into her left. Just a few weeks later, she could hear loud sounds, such as clapping, in her right ear. And after six months, her doctors, at Addenbrooke's Hospital, in Cambridge, confirmed that ear had almost normal hearing for soft sounds - even very quiet whispers. Hearing loss caused by a variation in the Otof gene is not commonly detected until children are two or three years old, when a delay in speech is likely. More than half of hearing-loss cases in children have a genetic cause. But genetic testing for at risk families is available on the NHS. Doctors in other countries, including China, are also exploring very similar treatments for the Otof gene mutation Opal has. Watch the video https://lnkd.in/euEN9Y3y Read ➡️ https://lnkd.in/eq9TWVpa #hearing #genetherapy #otofgene
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Anna Schwabe, PhD
🧬 Happy DNA Day! 🧬- From the AGRICULTURAL GENOMICS FOUNDATION April 25th marks the day in 1953 when James Watson, Francis Crick, Maurice Wilkins, Rosalind Franklin, and their colleagues published papers in the journal Nature on the structure of DNA. DNA is a molecule of incredible complexity and elegance, composed of just four nucleotide bases: adenine (A), thymine (T), cytosine (C), and guanine (G). Yet, from this simple code, arises the breathtaking diversity of life forms that inhabit our planet. Today, take a moment to marvel at the wonders of genetics and genomics. Thanks to DNA sequencing technologies, we've unlocked the secrets of our own genome and those of countless other species. This knowledge has revolutionized fields like personalized medicine, evolutionary biology, forensic science, and agriculture. DNA Day serves as a reminder of the importance of scientific discovery and collaboration. Watson, Crick, Franklin, and Wilkins' breakthrough was the result of years of research, collaboration, and the exchange of ideas. It highlights the power of interdisciplinary teamwork in unraveling the mysteries of the natural world. Happy DNA Day to scientists, researchers, educators, and enthusiasts everywhere! 🧬✨ #DNADay #Science #Genetics Daniela Vergara, Melissa Galbadores, and Valerie B.
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Jon O'Connell
We may have been underestimating the effects hydrodynamic forces have on protein aggregation. 💡 My thanks to the team at The Astbury Centre for Structural Molecular Biology, including Leon Willis, Sheena Radford, OBE, FRS, FMedSci, MAE, Nikil Kapur, and David Brockwell for giving us a deep look at their current understanding of how flow may induce aggregation. A couple of their suggestions for mitigating aggregation under flow. 👏Maybe it's your interface — thankfully, these days you're not stuck with stainless steel anymore; single-use technology gives you options. 🧪Or you need an excipient — sucrose or arginine may suppress aggregation under flow.
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Jonathan Pugh
Want something for free? I've always made the point that Oxford Nanopore Technologies nanopore sequencing is unrivalled in its ability to capture information - our raw signal is the most information-rich output you'll come across. Nanopore sequencing has not become more accurate over time, it's just that our models for querying what the hell is in that signal have got better! Case in point, Lavinia Grasso et al. I imagine the conversation around this work went something like this: "Hmm. Ribonucleotides in nuclear DNA look interesting. I wonder if we can use nanopore sequencing to spot them?" ***Makes ribonucleotide-containing dsDNA constructs, runs DNA through nanopore, checks data*** "Yup". This sort of info has been in genomic DNA all along, contributing to biology but largely going entirely unnoticed - or only visible through proxy with other methods. When you run native DNA through your nanopore all this stuff comes in your signal **for free**. What you're missing matters, even if you're blissfully unaware you're missing it! https://lnkd.in/eJvR8ect #wymm #nanopore #ribonucleotide #dna #sequencing
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Animal-Free Science Advocacy
Researchers have grown tumours in the lab to accurately predict what drugs will work for people with bowel cancer – before they begin treatment. The world-first study led by WEHI found drug testing on tumour organoids – 3D cancer models grown from a patient’s own tissue – could show how they will respond to a specific cancer treatment. A clinical trial is now being developed based on the results, which will be the first to validate organoid drug testing as an accurate way to guide treatment selection for people living with bowel cancer – the second-deadliest cancer in Australia. https://lnkd.in/g5z3wZqw
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Aoife Dillon
Do you ever look at the natural environment and think we can and should do better? A multitude of government policies and initiatives talk about delivering cleaner air, cleaner water and improved ecosystem function (e.g. flood mitigation, increased biodiversity etc), but are these policies ambitious enough and, are they being implemented according to the timelines described across the various policy documents? The Office for Environmental Protection (The OEP) is a public body that protects and improves the environment by holding government and other public authorities to account. To supplement the expertise within the organisation, the OEP created a College of Experts (around 50 volunteers). The College includes experts in the monitoring and implementation of environmental law, the natural, economic, and social sciences and those involved in the practical delivery of environmental strategies. As a member of the college, we volunteer our experience and knowledge to contribute across the remit of the OEP, including water, marine, land use and agriculture, biodiversity, soil health, waste and chemicals. Last week we had our first face to face meeting. It is a privilege to be part of this group and to support the OEP in their efforts to keep environmental improvement centre stage. The UK is the sixth-largest national economy in the world, measured by nominal gross domestic product (GDP). In terms of how we manage our environment, we can and should do better. #environment, #sustainability, #environmental law
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Imperial Entrepreneurs' Pledge
Introducing our featured pledger of the month, Alex Bond! 🌟🎓 During his PhD in Chemical Biology of Health and Disease, Alex delved into the intricate world of cell membranes, exploring how alterations in their composition could impact cellular behaviour. But Alex's time at Imperial extended far beyond academia. Utilising all corners of Imperial’s vibrant entrepreneurial ecosystem, Alex embarked on a transformative journey with Fresh Check: Confirming Hygiene, a startup aimed at revolutionising hygiene verification systems. From participating in the Venture Catalyst Challenge and the Greenhouse Accelerator, to developing the prototype at the Imperial College Advanced Hackspace and scaling the business in the Imperial White City Incubator. Reflecting on his time at Imperial, Alex fondly remembers the camaraderie of his peers, the supportive guidance of mentors, and the thrill of winning competitions like the CDT Den. Yet, it was the invaluable lessons learned from setbacks and challenges, such as navigating the uncertainties of the pandemic, that truly shaped his entrepreneurial resilience and determination. As CEO of FreshCheck, Alex continues to lead with passion and purpose, driving forward the mission to make contamination visible and safeguard public health. His vision for the future encompasses a range of innovative tools aimed at enhancing hygiene practices and mitigating health risks on a global scale. But Alex's journey isn't just about personal success—it's about giving back. Motivated by the support and guidance he received at Imperial, he remains committed to nurturing the next generation of innovators and entrepreneurs. By committing to the Imperial Entrepreneurs’ Pledge, Alex seeks to pay forward the invaluable mentorship and opportunities that paved the way for his own success. Alex’s advice to Imperial’s students is simple: “Take advantage of the environment around you. The support from Imperial is fantastic and it’s exciting to be involved in the startup world even if you don’t think you have an idea yet. It’s great to see other people’s ideas develop and learn about how ideation can actually be a process too.” Could you be a pledger? A gift of any size by an Imperial alumni could help accelerate progress in tackling some of the world’s most pressing challenges whilst giving students the chance to do what they love and fulfil their potential. To find out more about Imperial Entrepreneurs’ Pledge, visit: https://lnkd.in/eTuEBMpr #entrepreneurship #philanthropy #legacy #imperialmeansbusiness #enterprise #Inventedatimperial Imperial Enterprise | Imperial College London | Imperial Venture Mentoring Service (IVMS) | Imperial Enterprise Lab | Undaunted: Tackling climate change with innovation
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