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Arginine, Alanine and Aspartic Acid are the amino acids that make up the PuraBond hydrogel. ❌ No animal components ❌ No human components ✔️ A purely…
Arginine, Alanine and Aspartic Acid are the amino acids that make up the PuraBond hydrogel. ❌ No animal components ❌ No human components ✔️ A purely…
Liked by Luka Herceg
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If you have any kind of interest in business travel and the risks that accompany it, please listen to this webinar.
If you have any kind of interest in business travel and the risks that accompany it, please listen to this webinar.
Liked by Luka Herceg
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Today our team is at The Association of Coloproctology of Great Britain and Ireland (ACPGBI) conference in Wales, with our distributor Aquilant Ltd…
Today our team is at The Association of Coloproctology of Great Britain and Ireland (ACPGBI) conference in Wales, with our distributor Aquilant Ltd…
Liked by Luka Herceg
Experience & Education
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3-D Matrix EMEA
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Publications
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Mutagenicity and DNA-damaging potential of clenbuterol and its metabolite 4-amino-3,5-dichlorobenzoic acid in vitro
Food and Chemical Toxicology
See publicationThe aim of this study was to evaluate in vitro toxicity of clenbuterol and its metabolite 4-amino-3,5-dichlorobenzoic acid. Cytotoxicity and pro-oxidative effect of both compounds were studied on human colon adenocarcinoma cell line SW 480. No significant cytotoxic effect of either compound was observed. Results of an Ames test on Salmonella typhimurium did not indicate mutagenic activity of clenbuterol on TA 98 and TA 100 strains, regardless of metabolic activation. Potential mutagenic effects…
The aim of this study was to evaluate in vitro toxicity of clenbuterol and its metabolite 4-amino-3,5-dichlorobenzoic acid. Cytotoxicity and pro-oxidative effect of both compounds were studied on human colon adenocarcinoma cell line SW 480. No significant cytotoxic effect of either compound was observed. Results of an Ames test on Salmonella typhimurium did not indicate mutagenic activity of clenbuterol on TA 98 and TA 100 strains, regardless of metabolic activation. Potential mutagenic effects of the highest clenbuterol concentration (2500 ng/ml) were observed on the TA 1535 strain. The obtained results of alkaline comet assay on isolated human lymphocytes suggested that both compounds induced an increase of primary DNA damage in a concentration-dependent manner. 4-ADBA was a slightly more potent inducer of primary DNA damage as compared to clenbuterol. Chromosomal aberration analysis showed that clenbuterol caused a statistically significant increase in the total number of aberrant cells only at the highest concentration tested (3% vs. 0.7% in the negative control). The results of this study might represent a solid frame for designing and planning future studies with both compounds, which should further clarify their mechanisms of action and genotoxic/cytogenetic effects relevant for human risk assessment.
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English
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German
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Croatian
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Serbian
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Stay informed with the latest cases and peer experiences with our YouTube channel! Across GI, ENT, cardiac and more, we bring you the insights and…
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This week the 3-D Matrix EMEA team came together in Lyon, France for a couple of days of team building, strategising and collaborating. We had a…
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Our team had a wonderful time at the BRS Annual Meeting discussing PuraBond's use cases and scientific studies showcasing its impact within rhinology…
Our team had a wonderful time at the BRS Annual Meeting discussing PuraBond's use cases and scientific studies showcasing its impact within rhinology…
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Great example of PuraStats use in combination with other advanced techniques to treat an ampulloma! Thanks for sharing 🙏#ercp #purastat #Ampulloma
Great example of PuraStats use in combination with other advanced techniques to treat an ampulloma! Thanks for sharing 🙏#ercp #purastat #Ampulloma
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