ChunWei (Derrick) Hsu

台灣 臺北市 臺北市 聯絡資料
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關於

A business professional with a passion for leading marketing, developing partners, market…

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工作經歷和教育背景

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志工經歷

出版作品

  • Thesis: Large homozygous deletion in HeLa cell

    National Yang Ming University

    Aberrant chromosome rearrangement happening recurrently or non-recurrently would cause many human genetic diseases. Genetic instabilities consist of deletions, duplications, translocation and inversions of specific genomic segments which affect genes expression and may contribute to tumorigenesis. Through comparing the array CGH data of female leukocyte and HeLa cells, I have mapped some large homozygous deletion regions in HeLa cells. The deletion boundaries were further determined by…

    Aberrant chromosome rearrangement happening recurrently or non-recurrently would cause many human genetic diseases. Genetic instabilities consist of deletions, duplications, translocation and inversions of specific genomic segments which affect genes expression and may contribute to tumorigenesis. Through comparing the array CGH data of female leukocyte and HeLa cells, I have mapped some large homozygous deletion regions in HeLa cells. The deletion boundaries were further determined by systematically primer walking. After sequencing PCR products spanning the deleted regions, and comparing the upstream and downstream sequence at the boundaries, I found that some boundary regions have common features in the sequence context. I found enrichment of Alu repeat elements in some deletion which intersected deletion breakpoint at their polydA sequence and these flanking sequences showed highly similarity and direct repeat. These results suggest these deletions are mediated by homologous recombination between Alu repeat sequences flanking the deletions. However, some deletion boundaries showed no sequence homology and may be generated through other mechanism, such as NHEJ (Non-homologous end joining) after DNA double strand breaks. According to the array CGH, there are many deletion boundaries with high density repeat sequences nearby, which may explain the mechanisms of DNA repair. Finally, I also found deletions in tumor suppressor genes such as, FHIT/FRA3B, BAI3 and STK11/LKB1 and these deletions may lead to abnormal functions of gene and tumor development.

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獲頒專利

  • Motorcycle Helmet Cooling Apparatus And Method Of Use

    申請日期： US 62005937

    其他發明人

課程

  • Accounting

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  • Business Law-Startup

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  • Business model Analysis

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  • Commercialization of Biomedicine

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  • Finance

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  • IP strategy

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  • Leadership- General Management

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  • Microeconomics

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  • New Product Marketing

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  • Operations

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  • Strategy-New market

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專案

  • Expansion Strategy for Microsoft Azure

    Analysed the regions South East Asia, Latin America, Africa, Middle East for Microsoft to consider to opening new data centers or expand in the regions where it has data centers currently based on relevant factors and then narrowing down to candidate locations after considering relevant strategy frameworks (CAGE, ADDING value) and doing an industry analysis for those regions. The final report is for Microsoft Azure department for location recommendation. MBA project

    其他成員

測驗成績

  • IELTS

    成績：7.0/9.0

語言能力

  • English

    中高級（商務會話）

  • Chinese

    母語

  • Japanese

    初級

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研習以下課程，培養專業技能

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