Molecular Genetics

Molecular Genetics: Introduction

Faculty Affiliation

Medicine

Degree Programs

Genetic Counselling

MSc

Medical Genomics

MHSc

Molecular Genetics

MSc and PhD

Combined Degree Programs

MD / PhD

Collaborative Specializations

The following collaborative specializations are available to students in participating degree programs as listed below:

Overview

The Department of Molecular Genetics is administered from the Medical Sciences Building and has nearly 100 faculty members whose labs are located within the Medical Sciences Building, the MaRS Centre, the Donnelly Centre, the Hospital for Sick Children, Mount Sinai Hospital, and the Ontario Institute for Cancer Research.

Faculty members run a variety of research programs in diverse areas such as genetic models of development and disease; molecular medicine and human genetics; cellular and molecular structure and function; molecular microbiology and infectious disease; computational and systems biology; functional genomics and proteomics.

Contact and Address

Web: www.moleculargenetics.utoronto.ca
Email: mgy.info@utoronto.ca
Telephone: (416) 978-8359
Fax: (416) 978-6885

Department of Molecular Genetics
University of Toronto
Medical Sciences Building
Room 4398, 1 King's College Circle
Toronto, Ontario M5S 1A8
Canada

Molecular Genetics: Graduate Faculty

Full Members

Abelson, Sagi - PhD
Andrews, Brenda Jean - BSc, PhD
Andrulis, Irene - BA, PhD
Babaian, Artem - PhD
Bader, Gary - BSc, PhD
Blencowe, Benjamin - BSc, PhD
Boone, Charlie - BSc, PhD
Boulianne, Gabrielle - BSc, PhD
Brill, Julie - PhD
Brown, Martha - BSc, MSc, PhD
Campbell, Kieran - PhD
Ciruna, Brian - BSc, PhD
Claycomb, Julie - BS, BA, PhD
Cochrane, Alan - BSc, PhD
Collins, Rick - BSc, PhD
Cordes, Sabine - BS, PhD
Cowen, Leah - BSc, PhD
Culotti, Joseph - PhD
Davidson, Alan Richard - BSc, PhD
Delgado Olguin, Paul - BSc, PhD
Dennis, James - PhD
Derry, Brent - BSc, MSc, PhD
Deshwar, Ashish R. - MD
Dick, John - PhD
Dirks, Peter Benjamin - MD, PhD
Dowling, James - MD
Durocher, Daniel - PhD
Edwards, Aled - BSc, PhD
Egan, Sean - PhD (Associate Graduate Coordinator)
Ellis, James - PhD
Ernst, Oliver - PhD
Frappier, Lori - PhD (Graduate Coordinator)
Fraser, Andrew - BSc
Gallie, Brenda - MD
Gillis, Jesse - BSc, MSc, PhD
Gingras, Anne-Claude - BSc, PhD
Goeva, Aleksandrina - MS, ScD, SM, PhD
Gray-Owen, Scott - BS, PhD
Greenblatt, Jack - BSc, PhD
Hayes, Madeline - PhD
Hughes, Timothy - BMus, BSE, PhD (Chair and Graduate Chair)
Hui, Chi-Chung - PhD
Ivakine, Evgueni (Zhenya) - MSc, MSc, PhD
Jackson, Hartland - PhD
Joshi-Sukhwal, Sadhna - BSc, MSc, DSc, PhD
Kafri, Ran - BSc, MSc, PhD
Kaplan, David - BA, PhD
Kay, Lewis - PhD
Kim, Tae-Hee - PhD
Krause, Henry - BSc, PhD
Lavoie, Brigitte - PhD
Lefebvre, Julie - PhD
Lipshitz, Howard - PhD
Liu, Jun - PhD
Meneghini, Marc - BSc, PhD
Miller, Freda - BSc, PhD
Moffat, Jason - BSc, PhD
Moran, Michael - BSc, PhD
Morris, John - BS, PhD
Morris, Quaid - BS, PhD
Navarre, William - BSc, PhD
Okamoto, Kenichi - BS, MA, PhD
Park, Jeehye - PhD
Parkinson, John - BS, PhD
Pearson, Christopher - PhD
Pelletier, Laurence - BSc, MSc, PhD
Reimand, Juri - MSc, PhD
Reinke, Aaron - PhD
Rini, James - BSc, PhD
Rommens, Johanna - BSc, PhD
Rost, Hannes - PhD
Roth, Frederick - PhD
Roy, Peter John - BSc, PhD
Rozen-Gagnon, Kathryn - BA
Scherer, Stephen - PhD
Scott, Ian - BSc, PhD
Segall, Jacqueline - BSc, PhD
Sicheri, Frank - BSc, PhD
Smibert, Craig - BSc, PhD
Sondheimer, Neal John - MD, PhD
Spence, Andrew - BSc, PhD
Stagljar, Igor - BS, PhD
Stein, Lincoln - BA, MD, PhD
Steipe, Boris - MD, PhD
Taipale, Mikko - PhD
Tsukahara, Tatsuya - PhD
Tyers, Michael - PhD
Van Der Kooy, Derek - BSc, MA, PhD
Wang, Shu - ScD
Wilde, Andrew Rhys - BSc, PhD
Wrana, Jeff - PhD
Youn, Ji-Young - PhD
Yuen, Ryan - PhD
Zhang, Zhaolei - BS, PhD
Zhen, Mei - PhD
Zhu, Shankuan - PhD
Zhulyn, Olena - PhD

Members Emeriti

Aubin, Jane - BSc, PhD
Becker, Andrew - MD, PhD
Bernstein, Alan - MD
Carver, Jeremy - BA, PhD
Funnell, Barbara - PhD
Rossant, Janet - PhD
Sadowski, Paul - MD, PhD

Associate Members

Afonso, Samantha - MSc
Amburgey, Kimberly - MSc
Aronson, Melyssa - BS, MS
Babul-Hirji, Riyana - BSc, MSc
Care, Melanie - BSc, MSc
Carnevale, Amanda - MSc
Carroll, Johanna - BA, PhD
Chitayat, David - MD
Cytrynbaum, Cheryl - MSc
Druker, Harriet - MSc
Dupuis, Lucie - MSc
Flamenbaum, Kayla - MSc
Fung, Charlotte - MSc
Gallinger, Bailey - MSc
Gojska, Nicole - MSc
Graham, Tracy - MSc
Hewson, Stacy - MSc
Hill, Jessica - BSc, MSc, PhD
Hoang, Ny - MSc
Inglese, Cara - MSc
Johnstone, Brittney - MSc
Kaiser, Amy - BA
Klatt, Regan - BSc, MSc
Langlois, David J. - BA, MA, PhD
Lemmens, Trudo - LLM, DCL, Dr. William M. Scholl Chair in Health Law and Policy
Liston, Eriskay - BA, MSc
Lorentz, Justin - MSc
MacDonald, Heather - MSc
Martin, Nicole - BSc, MS
McCuaig, Jeanna - MS
Mendoza, Roberto - MD
Miller, Kristen - MSc
Murphy, Jillian - BSc, MSc
Myles Reid, Diane - BSc, MSc
Nguyen, Long - MD
Panchal, Seema - BSc, MSc
Peck, Larissa - MSc
Quercia, Nada - BS, MSc
Robertson, Carleigh - MSc
Semotiuk, Kara - BSc
Shugar, Andrea - BSc, MS
Shuman, Cheryl - MSc
Silver, Joshua - BSc, MSc
Silver, Rachel - BSc, MSc
Steele, Leslie - BSc, MSc
Steiner, Martina - PhD
Styles, Erin - BSc, PhD
Szego, Michael - BSc, MHSc, PhD
Szuto, Anna - MSc
Szybowska, Marta - MSc
Tam, Karen - BSc, MSc
Thain, Emily - MSc
Uster, Tamarah - BSc, MS
Volenik, Alexandra - MSc
Waldman, Larissa - MSc
Watkins, Nicholas - MSc
Weksberg, Rosanna - MD, PhD
Yoon, Grace - MD
Zahavich, Laura - MSc

Molecular Genetics: Genetic Counselling MSc

The Master of Science (MSc) program is a full-time degree program (non-thesis) that prepares students with academic knowledge and clinical skills so that upon graduating, they may work as highly competent genetic counsellors in a variety of practice settings. Genetic counsellors are employed in many areas of healthcare, providing genetic assessment and counselling to individuals and families with, or at risk for, a genetic disorder. There is also an increasing demand for genetic counsellors to join genetic/genomic testing laboratories, industry, public health settings, etc. Genetic counsellors are often involved in academic activities including teaching and research, administrative leadership roles, advisory roles for government and/or support organizations, and other precision medicine leadership capacities. This program is accredited by the Accreditation Council for Genetic Counseling.

MSc Program

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below.

  • A four-year undergraduate degree from a recognized university with a minimum B+ average, both cumulatively and in the upper years.

  • Successful completion or proof of current enrolment of undergraduate courses at a recognized university in biology, molecular biology/genetics, biochemistry, embryology/animal developmental biology, statistics, and psychology.

  • The development of strong interpersonal and communication skills, as evidenced by experience in a counselling setting (volunteer or paid).

  • All applicants must register with the National Matching System (NMS); instructions are provided in the department's application procedures.

Completion Requirements

  • Students must complete 13.0 full-course equivalents (FCEs) as follows:

    • 10.0 FCEs in coursework with a minimum B– standing. Lectures, meetings, and rounds must be attended at a minimum of 90% of scheduled occurrences.

      • MSC2010Y Molecular Medicine in Human Genetic Disease

      • MMG1120Y Clinical Rotations I

      • MMG1122Y Issues in Genetic Counselling I

      • MMG1124Y Principles of Effective Counselling

      • MMG1126Y Clinical Issues in Pregnancy and Child Development

      • MMG1128Y Risk Calculation and Research Methodology

      • MMG1130Y Tutorial in Molecular Genetics

      • MMG1132H Laboratory Skills

      • MMG1220Y Clinical Rotations II

      • MMG1222Y Issues in Genetic Counselling II

      • MMG1224Y Advanced Principles of Effective Counselling

      • MMG1226Y Concepts in Clinical Genetics

      • MMG1228Y Independent Research Project

      • MMG1230H Cancer Genetic Counselling.

    • 1.0 FCE independent research project. Students are expected to develop and implement a research study designed and carried out by them under the supervision of a faculty member. The independent research project must be relevant to the field of genetic counselling and/or clinical genetics. Students must present the independent research project both orally and in a written format suitable for publication.

    • 2.0 FCEs in clinical practicums.

  • Students spend a minimum of 21 months over a two-year period in full-time attendance.

  • Students are required to complete an intervening summer rotation (six weeks duration).

Mode of Delivery: In person
Program Length: 6 sessions full-time (typical registration sequence: FWS-FWS)
Time Limit: 3 years full-time

 

Molecular Genetics: Medical Genomics MHSc

The professional Master of Health Science (MHSc) program in Medical Genomics is a fast‐paced, content‐dense degree program delivered over five continuous sessions. This program will provide medical trainees, clinicians, research scientists, and laboratory professionals with the theory and practical knowledge necessary to incorporate the generation, analysis, and interpretation of genomics data into research and medical practice. Preferred applicants have relevant research and/or clinical experience and can demonstrate an immediate and substantive use of this degree in professional practice.

MHSc Program

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below.

  • An appropriate BSc degree with high academic standing from a recognized university, with a B+ average or better. Applicants would normally possess an undergraduate degree displaying competence in genetics, molecular biology, or related fields.

    or

    An appropriate MD degree with high academic standing from a recognized university, with a B+ average or better.

  • Applicants will complete an application package including:

    • all previous university transcripts

    • a transcript summary form for either the clinical or laboratory stream

    • curriculum vitae (CV)

    • statement of interest (one to two pages maximum), including how this program will have an impact on future career path

    • three letters of reference from professional, academic, or other qualified referees.

  • Interview (15 minutes).

Completion Requirements

Students must complete a total of 9.0 full-course equivalents (FCEs) as follows:

  • Year 1:

    • MMG3001Y Advanced Human Genetics (Fall and Winter)

    • MMG3002Y Biological Statistics (Fall)

    • MMG3003Y Genomics Methodologies (Winter and Summer).

  • Year 2:

    • MMG3004Y Communication of Genetic Information (Fall)

    • MMG3005Y Ethical and Legal Implications of Genomics (Fall)

    • MMG3007Y Clinical Practicum in Medical Genomics, an elective for clinical-stream students and trainees in patient-facing medical fields (Winter)
      or
      MMG3008Y Practicum in Modern Genomics, an elective for laboratory professional-stream students in clinical/research science careers (Winter).

  • Four elective modular courses from the following list (1.0 FCE):

    • MMG3201H Medical Genomics Graduate Professional Development (Summer)

    • MMG3202H Next-Generation Sequencing — Data Generation Laboratory (Summer)

    • MMG3203H Next-Generation Sequencing — Data Analysis and Interpretation (Summer)

    • MMG3204H Practical Applications of Genome Interpretation (Fall)

    • MMG3205H Research Topics in Medical Genomics (Fall).

Mode of Delivery: In person
Program Length: 5 sessions full-time (typical registration sequence: FWS-FW)
Time Limit: 3 years full-time

 

Molecular Genetics: Molecular Genetics MSc

The Master of Science (MSc) program offers research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.

Students may only start this program in September.

MSc Program

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below.

  • Normally, a BSc or MD degree or equivalent with excellent academic credentials in molecular biology, genetics, microbiology, and/or biochemistry. Applicants trained in other quantitative sciences (math, physics, chemistry, computer science, engineering, etc.) are also strongly encouraged to apply.

Completion Requirements

  • Coursework. Successful completion of 1.5 full-course equivalents (FCEs) as follows:

  • Students must also attend each of the following graduate seminars two times:

  • A thesis on a research project.

  • Defence of the thesis at an oral examination.

  • Residency. Students are required to spend 12 months in full-time attendance.

Mode of Delivery: In person
Program Length: 6 sessions full-time (typical registration sequence: FWS-FWS)
Time Limit: 3 years full-time

 

Molecular Genetics: Molecular Genetics PhD

The Doctor of Philosophy (PhD) program offers research training in a broad range of genetic systems from bacteria and viruses to humans. Research projects include DNA repair, recombination and segregation, transcription, RNA splicing and catalysis, regulation of gene expression, signal transduction, interactions of host cells with bacteria and viruses, developmental genetics of simple organisms (worms and fruit flies) as well as complex organisms (mice), molecular neurobiology, molecular immunology, cancer biology and virology, structural biology, and human genetics and gene therapy.

Applicants may enter the PhD program via one of three routes: 1) following completion of an MSc degree; 2) transfer from the University of Toronto MSc program; or 3) direct entry following completion of a BSc, MD, or equivalent degree.

Students may only start this program in September.

PhD Program

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below.

  • An MSc degree in Molecular Genetics, or equivalent, from the University of Toronto or another recognized university. As a condition of admission, applicants who have completed their MSc outside of the Department of Molecular Genetics may be required to complete additional course requirements.

  • Normally, an MSc degree or equivalent with wet or dry lab experience related to molecular biology, genetics, microbiology, and/or biochemistry is required. Applicants trained in other quantitative sciences (math, physics, chemistry, computer science, engineering, etc.) are also strongly encouraged to apply.

  • Attainment of minimum admission standards does not guarantee acceptance into the PhD program.

Completion Requirements

  • Coursework. Students must successfully complete a total of 1.0 full-course equivalent (FCEs) as follows:

    • MMG1115H PhD Presentation.

    • Two modular courses (0.25 FCE each), which must be taken after successfully completing the qualifying examination prior to the Summer session of Year 4. If a program extension is granted beyond Year 4, students have until the Summer session of Year 5 to complete.

  • Students must also attend each of the following graduate seminars four times:

  • A thesis on a research project.

  • Successful completion of a qualification examination in Year 2. The qualifying exam consists of the submission of a written proposal and an oral examination. If a student is unsuccessful at the first attempt at the qualifying exam, there are three possible outcomes:

    • The student may retake the oral exam within four to eight weeks without revision of the written proposal; or

    • The student may submit a revised written proposal and retake the oral exam within four to eight weeks; or

    • The student may withdraw from the program after consultation with the Graduate Coordinator. In cases where the student does not have an MSc in Molecular Genetics, the Exam Committee may recommend the student reclassify into the MSc program.

  • Residency. Students who enter the doctoral program after completing a master's program must spend a minimum of two sessions in full-time attendance.
Mode of Delivery: In person
Program Length: 4 years full-time (typical registration sequence: Continuous)
Time Limit: 6 years full-time

 

PhD Program (Transfer)

Transfer Requirements

  • Transfer applicants must be enrolled in the Department of Molecular Genetics MSc program.

  • Students must have successfully completed the following:

  • Students must be enrolled in MMG1111H and MMG1112H in order to qualify to transfer to the PhD program.

  • Transfer applicants must successfully complete a reclassification transfer exam within the first 24 months of registration in the MSc program.

Completion Requirements

  • Coursework. Students must successfully complete a total of 1.0 full-course equivalent (FCE) as follows:

    • MMG1115H PhD Presentation.

    • Two modular courses (0.25 FCE each), which must be taken after successfully completing the transfer examination and prior to the Summer session of Year 5.

  • Students must also attend any remaining graduate seminar sessions not completed prior to transferring. Students must attend each graduate seminar four times:

  • A thesis on a research project.

  • Successful completion of a transfer examination in Year 2. The transfer exam consists of the submission of a written proposal and an oral examination. If a student is unsuccessful at the first attempt at the transfer exam, there are four possible outcomes:

    • The student may retake the oral exam within four to eight weeks without revision of the written proposal; or

    • The student may submit a revised written proposal and retake the oral exam within four to eight weeks; or

    • The student is asked to complete and defend an MSc thesis; or

    • The student may withdraw from the program after consultation with the Graduate Coordinator.

  • Residency. Students who enter the doctoral program after completing a master's program must spend a minimum of two sessions in full-time attendance.

Mode of Delivery: In person
Program Length: 5 years full-time (typical registration sequence: Continuous)
Time Limit: 7 years full-time

 

PhD Program (Direct-Entry)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Molecular Genetics' additional admission requirements stated below.

  • Students with a BSc degree, an MD degree, or equivalent may be accepted directly into the PhD program.

  • Normally, a BSc degree or equivalent with academic credentials and wet or dry lab experience related to molecular biology, genetics, microbiology, and/or biochemistry is required. Applicants trained in other quantitative sciences (math, physics, chemistry, computer science, engineering, etc.) are also strongly encouraged to apply.

  • Attainment of minimum admission standards does not guarantee acceptance into the PhD program.

Completion Requirements

  • Coursework. Students must successfully complete a total of 2.5 full-course equivalents (FCEs) as follows:

    • MMG1001H Foundational Genetic Approaches I.

    • MMG1003H First Year Colloquium.

    • MMG1004H A Practical Course in Programming for Biologists.

    • MMG1113H MSc Presentation Skills.

    • MMG1114H MSc Presentation.

    • MMG1115H PhD Presentation.

    • Two modular courses (0.25 FCE each), which must be taken after successfully completing the qualifying examination and prior to the Summer session of Year 5.

  • Students must also attend each of the following graduate seminars four times:

  • A thesis on a research project.

  • Successful completion of a qualification examination in Year 2. The qualifying exam consists of the submission of a written proposal and an oral examination. If a student is unsuccessful at the first attempt at the qualifying exam, there are four possible outcomes:

    • The student may retake the oral exam within four to eight weeks without revision of the written proposal; or

    • The student may submit a revised written proposal and retake the oral exam within four to eight weeks; or

    • The student may choose to reclassify in the MSc program; or

    • The student may withdraw from the program after consultation with the Graduate Coordinator.

  • Residency. Students who enter the doctoral program after completing a master's program must spend a minimum of two sessions in full-time attendance.

Mode of Delivery: In person
Program Length: 5 years full-time (typical registration sequence: Continuous)
Time Limit: 7 years full-time

 

Molecular Genetics: Genetic Counselling MSc Courses

Required Courses

Course CodeCourse Title
Molecular Medicine in Human Genetic Disease
Clinical Rotations I
Issues in Genetic Counselling I
Principles of Effective Counselling
Clinical Issues in Pregnancy and Child Development
Risk Calculation and Research Methodology
Tutorial in Molecular Genetics
Laboratory Skills
Clinical Rotations II
Issues in Genetic Counselling II
Advanced Principles of Effective Counselling
Concepts in Clinical Genetics
Independent Research Project
Cancer Genetic Counselling

Molecular Genetics: Medical Genomics MHSc Courses

Required Courses

Course CodeCourse Title
Advanced Human Genetics
Biological Statistics
Genomics Methodologies
Communication of Genetic Information
Ethical and Legal Implications of Genomics

Required Elective (choose one)

Course CodeCourse Title
Clinical Practicum in Medical Genomics
Practicum in Modern Genomics

Modular Courses (choose any four, 0.25 FCE each)

Course CodeCourse Title
Medical Genomics Graduate Professional Development
Next-Generation Sequencing — Data Generation Laboratory
MMG3203HNext-Generation Sequencing — Data Analysis and Interpretation
MMG3204HPractical Applications of Genome Interpretation
MMG3205HResearch Topics in Medical Genomics

Molecular Genetics: Molecular Genetics MSc, PhD Courses

Course CodeCourse Title
Structural Biology: Principles and Practice
Protein Crystallography
Topics in Developmental Biology
Developmental Biology
Student Seminars in Developmental Biology
Foundational Genetic Approaches I
First Year Colloquium
MMG1004HA Practical Course in Programming for Biologists
Graduate Seminars I
Graduate Seminars II
MSc Presentation Skills
MMG1114HMSc Presentation
MMG1115HPhD Presentation
MMG1199HDirected Reading and Research Course
MMG1301HDevelopmental Neurobiology
MMG1302HAdvanced Imaging: Techniques and Application in Biological Systems
MMG1303HCell Cycle and Growth Control
MMG1304HBacterial Pathogens
MMG1305HComparative and Population Genomics
MMG1306HEpigenetics and Transcriptional Control
MMG1307HFungal Drug Resistance, Development, and Disease
MMG1308HHuman Genome Analysis
MMG1309HVirus Host Interactions
MMG1315HGene and Protein Evolution
MMG1316HCancer Genetics
MMG1317HSpecial Topics in Advanced Cancer Proteomics
MMG1318HCytoskeletal Dynamics
MMG1319HGenomics of Infectious Diseases
MMG1320HGenome Duplication, Repair, and Transmission
MMG1321HEukaryotic Signaling
MMG1322HProtozoan Pathogens
MMG1323HSignalling Networks in Development, Regeneration, and Disease
MMG1324HMitochondrial Genetics in Health and Disease
MMG1325HMolecular Mechanisms of Mood and Mind (M4)
MMG1326HPost‐Transcriptional Regulatory Mechanisms
MMG1327HMicrobiomes in Health and Disease
MMG1331HStem Cells II
MMG1333HVirus Replication
MMG1344HFoundational Computational Biology I
MMG1345HFoundational Computational Biology II
Signal Transduction and Cell Cycle Regulation