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• 1. Introduction : Community and Online Radio as Emerging Frontiers of South African Audio broadcasting: An introduction
• 2. Creating an enabling policy environment for democratic participation through community radio: Perspectives of a practitioner
• 3: Language Revitalization and Community Broadcasting in South Africa: A Case of Vaaltar FM
• 4. The Role of Community Radio in Youth Empowerment: A Case Study of Bush Radio
• 5. Radio Waves of Inclusion: A Practitioner's Perspective on the Catholic Church's Use of Radio Broadcasting for Evangelisation in South Africa
• 6. More than just Edutainment: Indigenous South African community radio music programmes as preservers of African Traditional Cultures
• 7. Radio and social media convergence: Motsweding's use of WhatsApp and the African language digital public sphere
• 8. Radio production in the digital era: lessons from South Africa
• 9. Podcasting Unleashed: Amplifying Indigenous Language Speakers' Agency in South Africa's Shifting Media Terrain
• 10. Evolving trends in radio broadcasting in South Africa: the case of Podcast and Chill with MacG
• 11. Final thoughts_Community Radio and the Digital Milieu: Challenges and Opportunities for the next century of South Africa's Radio Landscape.

Digital government is essential to transform government processes and services in ways that improve the responsiveness and reliability of the public sector. During the COVID-19 pandemic it also proved crucial to governments' ability to continue operating in times of crisis and provide timely services to citizens and businesses. Yet, for the digital transformation to be sustainable in the long term, it needs solid foundations, including adaptable governance arrangements, reliable and resilient digital public infrastructure, and a prospective approach to governing with emerging technologies such as artificial intelligence. This paper presents the main findings of the 2023 edition of the OECD Digital Government Index (DGI), which benchmarks the efforts made by governments to establish the foundations necessary for a coherent, human-centred digital transformation of the public sector. It comprises 155 data points from 33 member countries, 4 accession countries and 1 partner country collected in 2022, covering the period between 01 January 2020 and 31 October 2022.

• Introduction
• Paired measures
• Paired complementary measures
• Unitary measures
• Number needed (reciprocal) measures and their combinations as likelihoods
• Quality (Q) measures
• Graphing methods
• Other measures, other tables
• Classification of metrics of binary classification.

This book describes, extends, and illustrates the metrics of binary classification through worked examples. Worked examples based on pragmatic test accuracy study data are used in chapters to illustrate relevance to day-to-day clinical practice. Readers will gain an understanding of sensitivity and specificity and predictive values along with many other parameters. The contents are highly structured, and the use of worked examples facilitates understanding and interpretation. This book is a resource for clinicians in any discipline who are involved in the performance or assessment of test accuracy studies and professionals in the disciplines of machine learning or informatics wishing to gain insight into clinical applications of 2x2 tables.

• Introduction
• Started From the Bottom, and Now I'm Here
• Embracing 3 Hours a Day
• Step 1: Hone Your Superpower
• Step 2: Evaluate Your Business
• Step 3: Balance Your Business
• Step 4: Delegate Your Business
• Step 5: Systematize Your Business
• Step 6: Design Your 3 Hours a Day
• Step 7: Quadruple Your Income with 3 Hours a Day
• Overcoming the Challenges of 3 Hours a Day
• Frequently Asked Questions About 3 Hours a Day

"Williams, also known as The Business Healer, shows you how to transform your work life in a proven 7-step process that includes prioritizing dollar-producing activities while relegating non-dollar producing activities to your capable crew. You'll also learn how to take a dive deep into your own business to find out what's working and what's not, through the 8 Pillars of Success: mindset, activities, people, systems, tools, money, accountability, and training"-- Provided by publisher

31 Days Before Your Cisco Certified Support Technician (CCST) Networking 100-150 Exam is the friendliest, most practical way to understand the Cisco Certified Support Technician (CCST) Networking certification process, to commit to taking your CCST Networking 200-301 exam, and to finish your preparation using a variety of primary and supplemental study resources. This portable guide offers a complete day-by-day plan for what and how to study. From the basics of standards and concepts, to addressing and subnet formats, infrastructure, and security, youll find it here. Each day breaks down an exam topic into a short, easy-to-review summary, with daily Study Resources pointing to deeper treatments elsewhere. Sign up for your exam now, and use this day-by-day guide and checklist to organize, prepare, review, and succeed!

• 3D Cell Culture: Techniques For and Beyond Organoid Applications
• Preparation of Corneal Tissue Matrix Bioink for 3D Bioprinting
• Decellularization of Pig Lung to Yield Three-Dimensional Scaffold for Lung Tissue Engineering
• Three-Dimensional Hanging Drop Spheroid Plates for Easy Chimeric Antigen Receptor (CAR) T Cytotoxicity Assay
• Static 3D Osteoblast Cell Culture on 3D Printed Titanium Scaffolds
• Modelling Acute Myeloid Leukaemia using StarPEG-Heparin Hydrogels
• A Decision Tree to Guide Human and Mouse Mammary Organoid Model Selection
• Fibroblast-Epithelium Co-Culture Methods using Epithelial Organoids and Cell Line-Derived Spheroids
• Differentiation of Fibroblasts to Adipocytes in 3D for a Co-Culture with Mammary Organoids and Immunohistological Analysis
• Organotypic 3D Cell Culture of the Embryonic Lacrimal Gland
• Renal Organoids from Whole Kidney Cells
• Organotypic 3D Ex Vivo Co-Culture Model of the Macro-Metastasis/Organ Parenchyma Interface
• Addressing the Mechanical Interaction between Cancer-Associated Fibroblasts and Cancer Cells by Laser Ablation
• Double-Barrel Perfusion System for Modification of Luminal Contents of Intestinal Organoids
• Mechanical Actuation of Organoids in Synthetic Microenvironments
• 3D Breast Cancer Model on Silk Fibroin-Integrated Microfluidic Chips
• Tumor-Microenvironment-on-Chip Platform for Assessing Drug Response in 3D Dynamic Culture
• Suspended 3D Bioprinting for Engineering Miniaturized In Vitro Tumor Models
• Real-Time Cell Cycle Imaging in a 3D Cell Culture Model of Melanoma, Quantitative Analysis, Optical Clearing, and Mathematical Modeling
• Quantitative Analysis of Whole-Mount Fluorescence-Stained Tumor Spheroids in Phenotypic Drug Screens.

Since the publication of the previous edition, the use of 3D cell and organoid cultures has become more widespread across laboratories. This second edition volume expands on the previous edition with discussions about the latest organoid models developed for many more organs; new hydrogels and devices for 3D culture; and the organoid systems that have been improved by incorporating more components of tissue microenvironments in the in vitro culture. The chapters in this book are organized into five parts and cover topics such as biofabrication, organoids, microfluidic systems, bioprinting, and image analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, 3D Cell Culture: Methods and Protocols, Second Edition is a valuable resource that will stimulate new ideas, foster interdisciplinary collaborations, and contribute to the improvement of human health and well-being.

• Foreword to the 2nd Edition
• Chapter 1 Introduction
• Chapter 2 Image processing including software considerations for medical 3D printing
• Chapter 3 Pre-processing and Preparation of Medical 3D Printed Models
• Chapter 4 3D Printing Technologies and Materials
• Chapter 5 Thoracic 3D Printing
• Chapter 6 Cardiac 3D Printing
• Chapter 7 Musculoskeletal 3D Printing
• Chapter 8 3D Printing in Oral and Maxillofacial Surgery
• Chapter 9 Case Examples of Advanced 3D Printing in Hospitals and Medical Centers
• Chapter 10 3D Printing and Digital Design for Maxillofacial Prosthetics
• Chapter 11 Patient-Specific Planning in Head and Neck Reconstruction including Virtual Reality
• Chapter 12 3D Printing and Neurotechnology in Cranial Reconstruction
• Chapter 13 3D Printing in Neurosurgery and Neurovascular Intervention
• Chapter 14 Application of 3D printing in the Spine
• Chapter 15 Applications of 3D printing in the Abdomen and Pelvis
• Chapter 16 3D Printing in the Management of Breast Cancer
• Chapter 17 Radiological Society of North America (RNSA) : American College of Radiology (ACR) 3D Printing Registry
• Chapter 18 Establishing a Medical 3D Printing Lab and Considerations for Ensuring Quality of the 3D Printed Medical Parts
• Chapter 19 3D Printing in Medical Education
• Chapter 20 Biofabricated Tissues & Organs
• Chapter 21 FDA Regulatory Pathways and Technical Considerations for the 3D Printing of Medical Models and Devices
• Chapter 22 Augmented & Virtual Reality in Medicine
• Back matter and after word (in memoriam).

This new edition describes the fundamentals of three-dimensional (3D) printing as applied to medicine and extends the scope of the first edition of 3D Printing in Medicine to include modern 3D printing within Health Care Facilities, also called at the medical "Point-Of-Care" (POC). This edition addresses the practical considerations for, and scope of hospital 3D printing facilities, image segmentation and post-processing for Computer Aided Design (CAD) and 3D printing. The book provides details regarding technologies and materials for medical applications of 3D printing, as well as practical tips of value for physicians, engineers, and technologists. Individual, comprehensive chapters span all major organ systems that are 3D printed, including cardiovascular, musculoskeletal, craniomaxillofacial, spinal, neurological, thoracic, and abdominal. The fabrication of maxillofacial prosthetics, the planning of head and neck reconstructions, and 3D printed medical devices used in cranial reconstruction are also addressed. The second edition also includes guidelines and regulatory considerations, costs and reimbursement for medical 3D printing, quality assurance, and additional applications of CAD such as virtual reality. There is a new Forward written by Ron Kikinis, PhD and a new Afterword written by Michael W. Vannier, MD. This book offers radiologists, surgeons, and other physicians a rich source of information on the practicalities and expanding medical applications of 3D printing. It will also serve engineers, physicist, technologists, and hospital administrators who undertake 3D printing. The second edition is designed as a textbook and is expected to serve in this capacity to fill educational needs in both the medical and engineering sectors.

• Overview of Pharmaceutical 3D Printing Technologies
• Clinical Benefit of 3D Printed Products
• Characterization or Quality Control of 3D Printed Products
• Polymers for HME based 3D Printing
• Cellulosic Polymers
• API and Polymer Selection Formulation and Process Variables
• Fused Deposition Modeling 3D Printing.-Semi-solid Extrusion Printing and 3D
• Future Trends Including Novel Polymeric Excipients Designed for Purpose Bioprinting.

This book is an educational text and guide for the use and properties of key polymeric excipients in the area of 3D printing in drug development. It is written by both industry experts and academic researchers. The particular focus is on hot melt extrusion and the extruded filaments suitable for optimizing the 3D printing in drug development. 3D Printing Polymeric Excipients, Technology, and Drug Formulation Development covers regulatory aspects as well as the manufacturing aspects.

"Three-dimensional printing (3DP) also known as Additive Manufacturing (AM) has emerged as exciting technology for the manufacture of pharmaceutical products for personalised patient treatment. The interindividual variability of the human population is a constant challenge when striving for effective drug delivery because patients come in different shapes, sizes, ages, genetics and necessities and so require medication personalised to their needs for the most effective outcomes [1] [2]. 3DP has been shown to be a flexible technique which can be used to manufacture drug delivery devices (DDD) for a wide array of applications such as tablets, implants, microneedles and suppositories [3-5]. In addition, compared to conventional large scale production techniques, such as tablet pressing, 3DP is much more agile with the potential to simplify supply chains and accelerate development cycles. Such traits, make 3DP an ideal candidate technology to produce on-demand personalized medicines and in turn, improve patient quality of life. However, there are still several challenges hindering its adoption. Limited availability of biocompatible materials, the incompatibility of the API and or polymer with the printing conditions and regulatory hurdles presents a significant challenge when designing 3DP pharmaceutical products. This is highlighted by the presence of just one 3DP pharmaceutical product currently on the market, Spritam® [6]. Material choice is a fundamental consideration when designing a pharmaceutical dosage form. All drug products are comprised of an active pharmaceutical ingredient (API) which is the bioactive component and inactive functional excipients which facilitate the release of the API to the target location in the body. With the advance of 3D printing medicine, API carrier materials have an increasingly important role in not only protecting the API in a convenient printable package and disguising unpalatable ingredients but also in facilitating complex release profiles. Several 3D printing techniques are applicable for manufacturing DDD: Thermal Extrusion-based deposition systems (TE), Semi-solid extrusion (SSE), Stereolithography (SLA) and Powder Bed fusion (PBF). Successful printing of pharmaceuticals requires consideration of the nature of the 3D printing process. Each technique has its own benefits and limitations in terms of material compatibility, print quality and scalability and so must be considered as a whole when designing a new DDD. The objective of this book chapter is to first discuss each printing technique exploring the key material characteristics and processing parameters that influence both printability and drug delivery performance. Subsequently, the materials which have shown suitability for 3DP manufacture of DDD will be discussed with a focus on the key material attributes relevant for printing and drug release properties"-- Provided by publisher.