[citation report] Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial

Cited by 84 publications

(82 citation statements)

References 34 publications

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“…Consistent with the findings in ESRRA null mice, ESRRA inverse agonists, compound 29 (C29) and compound 50 (C50), also show obesity resistance in DIO mouse models [94][95][96]. Recent studies on the ESRRA activator, genistein, have shown beneficial effects in preclinical dietary NAFLD models, as well as in a randomized, controlled clinical trial on NAFLD patients [97][98][99][100][101]. Genistein increases AMPK activity, lipid catabolism, and mitochondrial activity, while reducing de novo lipogenesis.…”

Section: Esrra As a Target For Nafldsupporting

confidence: 64%

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi

Yen

Singh

2020

IJMS

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The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism.ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

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Section: Esrra As a Target For Nafldsupporting

confidence: 64%

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Tripathi

Yen

Singh

2020

IJMS

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“…Despite no inhibition of hepatic steatosis, genistein can attenuate steatohepatitis induced in methionine‐choline‐deficient (MCD) diet‐fed mice by alleviating AMPK inactivation and suppressing inflammation . In a recently conducted trial, oral supplementation with genistein could reduce insulin resistance, oxidative, and inflammatory indices along with improvement in fat metabolism in patients with NAFLD . Anthocyanins belong to a class of plant flavonoids rich‐contained in the berries of bilberry and black currant.…”

Section: Nafld Therapeutics From a Mitochondria‐centric Perspectivementioning

confidence: 99%

Mitochondria‐Mediated Pathogenesis and Therapeutics for Non‐Alcoholic Fatty Liver Disease

Zhang

et al. 2019

Molecular Nutrition Food Res

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Non‐alcoholic fatty liver disease (NAFLD) has become a worldwide epidemic over the last decade. Remarkable progress has been made in understanding the pathogenesis of NAFLD and, subsequently, in developing medications to treat this disease. Although the mechanisms of NAFLD are complex and multifactorial, accumulating and emerging evidence indicates that mitochondria play a critical role in the pathogenesis and progression of NAFLD. Pharmacologic therapies acting on mitochondria may therefore pave the way to novel strategies for the prevention and protection against NAFLD. This review focuses on new insights into the role of hepatic mitochondrial dysfunction in NAFLD, and summarizes recent studies on mitochondria‐centric therapies for NAFLD utilizing new medications or repurposing of currently available drugs. Although some studies presented may feature controversial results or are still in lack of clinical verification, it is undoubted that medications that may spare the mitochondria from multiple levels of damage are highly promising, and have begun to be used with some degree of success.

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“…13,14 Subsequently, emerging clinical trials and animal experiments verified the benefits of genistein on glucose intolerance, insulin sensitivity and lipid profile disorders. 15,16 It has been indicated that the potential mechanisms deciphering the protective effects of genistein against metabolic disorders included directly enhancing the proliferation of β-cells, inhibiting apoptosis, promoting insulin secretion, epigenetic modifications, regulating the cAMP/PKA signaling pathway, and modulating the gut microbiota. 12,17 However, studies exploring the effects and mechanism of perinatal genistein consumption on transgenerational metabolic health are lacking.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

et al. 2019

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Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial

Cited by 84 publications

References 34 publications

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

Mitochondria‐Mediated Pathogenesis and Therapeutics for Non‐Alcoholic Fatty Liver Disease

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

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