2015
DOI: 10.1001/jama.2015.12790
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Association of Tdap Vaccination With Acute Events and Adverse Birth Outcomes Among Pregnant Women With Prior Tetanus-Containing Immunizations

Abstract: Among women who received Tdap vaccination during pregnancy, there was no increased risk of acute adverse events or adverse birth outcomes for those who had been previously vaccinated less than 2 years before or 2 to 5 years before compared with those who had been vaccinated more than 5 years before. These findings suggest that relatively recent receipt of a prior tetanus-containing vaccination does not increase risk after Tdap vaccination in pregnancy.

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Cited by 99 publications
(49 citation statements)
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“…Sukumaran et al addressed this concern in a retrospective cohort study of N D 4,812), 2 to 5 (N D 9,999) and more than 5 y (N D 14,344) previously. 57 No significant differences in rates of medically-attended adverse events or adverse birth outcomes (preterm delivery, low birth weight, small for gestational age) were found. It is possible that this tolerance of short tetanus vaccination intervals in pregnant women may be related to the natural immunosuppression of pregnancy, with differences in humoral and cell-mediated responses and natural killer cells that occur to protect the fetus, compared with the non-pregnant population.…”
Section: Safety Of Pertussis Immunization In Pregnancymentioning
confidence: 89%
“…Sukumaran et al addressed this concern in a retrospective cohort study of N D 4,812), 2 to 5 (N D 9,999) and more than 5 y (N D 14,344) previously. 57 No significant differences in rates of medically-attended adverse events or adverse birth outcomes (preterm delivery, low birth weight, small for gestational age) were found. It is possible that this tolerance of short tetanus vaccination intervals in pregnant women may be related to the natural immunosuppression of pregnancy, with differences in humoral and cell-mediated responses and natural killer cells that occur to protect the fetus, compared with the non-pregnant population.…”
Section: Safety Of Pertussis Immunization In Pregnancymentioning
confidence: 89%
“…Therefore, individuals who have completed their childhood vaccinations should also be administered adulthood vaccinations (8). Worldwide, vaccination rates are lower in adults than in children (5,15,16). The reason for the low adult vaccination rate is the belief that the vaccination is usually performed in childhood (30).…”
Section: Discussionmentioning
confidence: 99%
“…The status of adult vaccination is very low in our country as in the world (14)(15)(16)(17)(18)(19). Although vaccination is one of the key applications of preventive health care, little attention is paid to adult vaccination, especially to the vaccination of older individuals.…”
mentioning
confidence: 99%
“…A retrospective study of same authors measured the risk of acute adverse events and adverse events at birth in women receiving Tdap vaccine during pregnancy, and who had previously received tetanus vaccine. It was concluded that prior vaccination with tetanus vaccine does not increase the risk of acute adverse effects or the incidence of preterm or small gestational age in patients receiving Tdap vaccine during pregnancy 30 . Table 2 summarizes the safety evidence presented.…”
Section: Effectiveness and Safety Of Tdap Antenatal Vaccinementioning
confidence: 99%