[citation report] DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3

Cited by 67 publications

(98 citation statements)

References 58 publications

(87 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These alterations include mutations in JAK2 , NRAS and KRAS , mutations or overexpression of CRLF2, and trisomy 21 (Figure 1). While the specific genes on Hsa21 that participate in B-ALL have been unclear, recent studies implicate HMGN1 (35), and DYRK1A (36). Several other genetic events have been found in DS-ALL, including IKZF1 deletion (37, 38), PAX5 deletion (39, 40), ETV6-IGH rearrangement (41), and histone gene deletions (42).…”

Section: Genetics Of Ds-allmentioning

confidence: 99%

“…Two recent studies have implicated specific Hsa21 genes, HMGN1 and DYRK1A , in lymphopoiesis and the disease process (35, 36). …”

Section: Driving Events In Ds-allmentioning

confidence: 99%

“…DYRK1A may play a role in promotion of ALL, but, likely through a pathway different from that in AMKL, as Dyrk1a was recently shown to be essential for lymphoid, but not myeloid, cell development (36). Ablation of Dyrk1a in the proliferative stages of pre-B and pre-T cells led to a transcriptional up-regulation of cell cycle-promoting genes.…”

Section: Driving Events In Ds-allmentioning

confidence: 99%

“…There have been previous studies suggesting a significant role for DYRK1A in cell cycle regulation in other tissues, such as phosphorylation of Lin52 (S28) and consequential assembly of the cell cycle regulatory DREAM complex (68) or phosphorylation and stabilization of p27 (69). Within developing lymphocytes, DYRK1A phosphorylates cyclin D3 on T283, a highly conserved phosphodegron site among D-type cyclins (36). Furthermore, degradation of phosphorylated cyclin D3 was associated with repression of E2F target genes.…”

Section: Driving Events In Ds-allmentioning

confidence: 99%

“…Thus by negatively regulating cyclin D3 stability, DYRK1A plays a major role shifting lymphocytes from proliferation to quiescence. Despite the fact that Dyrk1a deficient cells fail to enter quiescence, they did not accumulate in the animal (36). Rather, large pre-B cells lacking Dyrk1a completed fewer cell divisions than control cells, indicating that DYRK1A has additional roles in cell growth.…”

Section: Driving Events In Ds-allmentioning

confidence: 99%

See 4 more Smart Citations

The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome

et al. 2016

View full text Add to dashboard Cite

Children with Down syndrome (DS) are at a 20-fold increased risk for acute lymphoblastic leukemia (DS-ALL). Although the etiology of this higher risk of developing leukemia remains largely unclear, the recent identification of CRLF2 and JAK2 mutations and study of the effect of trisomy of Hmgn1 and Dyrk1a on B-cell development have shed significant new light on the disease process. Here we focus on the clinical features, biology, and genetics of ALL in children with DS. We review the unique characteristics of DS-ALL on both the clinical and molecular levels and discuss the differences in treatments and outcomes in ALL in children with DS compared to those without DS. The identification of new biological insights is expected to pave the way for novel targeted therapies.

show abstract

Section: Genetics Of Ds-allmentioning

confidence: 99%

“…Two recent studies have implicated specific Hsa21 genes, HMGN1 and DYRK1A , in lymphopoiesis and the disease process (35, 36). …”

Section: Driving Events In Ds-allmentioning

confidence: 99%

Section: Driving Events In Ds-allmentioning

confidence: 99%

Section: Driving Events In Ds-allmentioning

confidence: 99%

Section: Driving Events In Ds-allmentioning

confidence: 99%

See 3 more Smart Citations

The biology, pathogenesis and clinical aspects of acute lymphoblastic leukemia in children with Down syndrome

et al. 2016

View full text Add to dashboard Cite

show abstract

Cell cycle RNA regulons coordinating early lymphocyte development

Galloway

Turner

2017

WIREs RNA

View full text Add to dashboard Cite

Lymphocytes undergo dynamic changes in gene expression as they develop from progenitor cells lacking antigen receptors, to mature cells that are prepared to mount immune responses. While transcription factors have established roles in lymphocyte development, they act in concert with post‐transcriptional and post‐translational regulators to determine the proteome. Furthermore, the post‐transcriptional regulation of RNA regulons consisting of mRNAs whose protein products act cooperatively allows RNA binding proteins to exert their effects at multiple points in a pathway. Here, we review recent evidence demonstrating the importance of RNA binding proteins that control the cell cycle in lymphocyte development and discuss the implications for tumorigenesis. WIREs RNA 2017, 8:e1419. doi: 10.1002/wrna.1419For further resources related to this article, please visit the WIREs website.

show abstract