[citation report] Characteristic cardiac phenotypes are detected by cardiovascular magnetic resonance in patients with different clinical phenotypes and genotypes of mitochondrial myopathy

Cited by 60 publications

(52 citation statements)

References 38 publications

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“…Another interesting mechanism involved in the development of the LGE pattern observed in MELAS patients might be vessels leakage due to mitochondrial angiopathy, such as for stroke-like lesions [9]. The vasogenic effect translates into changes in microvascular permeability and extracellular edema formation that may in part contribute to the myocardial LGE [9]. That is in accordance with the presence of multifocal edema at the T2-STIR sequences [9].…”

Section: Discussionmentioning

confidence: 90%

“…Furthermore, late gadolinium enhancement (LGE) at MRI, which reflects expansion of the myocardial interstitium caused by disperse interstitial fibrosis, partial myocardial disarray, and fibrous replacement of irreversibly injured myocytes, was present in 73% of patients ( n = 8/11) with a diffuse, nonischemic (predominantly intramural), patchy pattern [9], such as in the presented case. Another interesting mechanism involved in the development of the LGE pattern observed in MELAS patients might be vessels leakage due to mitochondrial angiopathy, such as for stroke-like lesions [9]. The vasogenic effect translates into changes in microvascular permeability and extracellular edema formation that may in part contribute to the myocardial LGE [9].…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, cardiac-CT can be useful to exclude obstructive coronary artery disease in the acute evaluation of chest pain patients presenting with normal or low-positive troponin-elevation [8]. According to a recent study [9], the presence of a concentric hypertrophic remodelling pattern is frequently found in MELAS-like patients. Furthermore, late gadolinium enhancement (LGE) at MRI, which reflects expansion of the myocardial interstitium caused by disperse interstitial fibrosis, partial myocardial disarray, and fibrous replacement of irreversibly injured myocytes, was present in 73% of patients ( n = 8/11) with a diffuse, nonischemic (predominantly intramural), patchy pattern [9], such as in the presented case.…”

Section: Discussionmentioning

confidence: 99%

“…According to a recent study [9], the presence of a concentric hypertrophic remodelling pattern is frequently found in MELAS-like patients. Furthermore, late gadolinium enhancement (LGE) at MRI, which reflects expansion of the myocardial interstitium caused by disperse interstitial fibrosis, partial myocardial disarray, and fibrous replacement of irreversibly injured myocytes, was present in 73% of patients ( n = 8/11) with a diffuse, nonischemic (predominantly intramural), patchy pattern [9], such as in the presented case. Another interesting mechanism involved in the development of the LGE pattern observed in MELAS patients might be vessels leakage due to mitochondrial angiopathy, such as for stroke-like lesions [9].…”

Section: Discussionmentioning

confidence: 99%

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MELAS Syndrome with Cardiac Involvement: A Multimodality Imaging Approach

Seitun

Massobrio

Rubegni

et al. 2016

Case Reports in Cardiology

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A 49-year-old man presented with chest pain, dyspnea, and lactic acidosis. Left ventricular hypertrophy and myocardial fibrosis were detected. The sequencing of mitochondrial genome (mtDNA) revealed the presence of A to G mtDNA point mutation at position 3243 (m.3243A>G) in tRNA Leu(UUR) gene. Diagnosis of cardiac involvement in a patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes syndrome (MELAS) was made. Due to increased risk of sudden cardiac death, cardioverter defibrillator was implanted.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

MELAS Syndrome with Cardiac Involvement: A Multimodality Imaging Approach

Seitun

Massobrio

Rubegni

et al. 2016

Case Reports in Cardiology

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“…This study aimed to characterize the prevalence and pattern of cardiac abnormalities and to test the additional diagnostic value of CMR in this patient population [82]. Based on assessment of 64 MM patients, cardiac involvement was a frequent finding in MM patients.…”

Section: Cardiomyopathymentioning

confidence: 99%

Review of Journal of Cardiovascular Magnetic Resonance 2015

Pennell

Baksi

Prasad

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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There were 116 articles published in the Journal of Cardiovascular Magnetic Resonance (JCMR) in 2015, which is a 14 % increase on the 102 articles published in 2014. The quality of the submissions continues to increase. The 2015 JCMR Impact Factor (which is published in June 2016) rose to 5.75 from 4.72 for 2014 (as published in June 2015), which is the highest impact factor ever recorded for JCMR. The 2015 impact factor means that the JCMR papers that were published in 2013 and 2014 were cited on average 5.75 times in 2015. The impact factor undergoes natural variation according to citation rates of papers in the 2 years following publication, and is significantly influenced by highly cited papers such as official reports. However, the progress of the journal's impact over the last 5 years has been impressive. Our acceptance rate is <25 % and has been falling because the number of articles being submitted has been increasing. In accordance with Open-Access publishing, the JCMR articles go on-line as they are accepted with no collating of the articles into sections or special thematic issues. For this reason, the Editors have felt that it is useful once per calendar year to summarize the papers for the readership into broad areas of interest or theme, so that areas of interest can be reviewed in a single article in relation to each other and other recent JCMR articles. The papers are presented in broad themes and set in context with related literature and previously published JCMR papers to guide continuity of thought in the journal. We hope that you find the open-access system increases wider reading and citation of your papers, and that you will continue to send your quality papers to JCMR for publication.

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