[citation report] Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice

Cited by 31 publications

(25 citation statements)

References 47 publications

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“…It is a pathological process that often leads to hepatocellular carcinoma (Iwaisako, Brenner, & Kisseleva, 2012), which is one of the major causes of morbidity and mortality worldwide (Jia et al, 2015). Carbon tetrachloride (CCl4) is commonly used to induce liver injury, and it has been shown that the CCl4-induced liver oxidative damage responses in animals are similar to those in humans (Hsu et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Protective effect and mechanism of action of mulberry marc anthocyanins on carbon tetrachloride-induced liver fibrosis in rats

Yang

Jia

et al. 2016

Journal of Functional Foods

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Section: Introductionmentioning

confidence: 99%

Protective effect and mechanism of action of mulberry marc anthocyanins on carbon tetrachloride-induced liver fibrosis in rats

Yang

Jia

et al. 2016

Journal of Functional Foods

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“…So, there is a need to understand mechanism of action behind all these spectacular properties of PQQ. Oxidation of glucose phosphorylation of ADP, metabolized by Entner-Doudoroff pathway [67] 16.…”

Section: Resultsmentioning

confidence: 99%

“…Six pqq genes and one GDh gene has been identified in R. aquatilis strains, found necessary for biosynthesis of the Antibacterial substqnceABS, as biocontrol of crown gall disease [67]. The (GDHm) is a 86 kDa [68] double mutants of PQQ are more sensitive and ndvB stimulates antibiotic resistance by sequestration of drugs in cyclic glucans and ethanol oxidation genes activates antibiotic resistance ( Figure 6) [69].…”

Section: Pqq Role In Antibioticsmentioning

confidence: 99%

The Life History of Pyrroloquinoline Quinone (PQQ): A Versatile Molecule with Novel Impacts on Living Systems

Naveed¹

2016

IJMBOA

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Pyrroloquinoline quinone (PQQ) acting as redox cofactor of Glucose dehydrogenase is orthocyclic antioxidant acting under multifarious environmental stress and rich conditions in prokaryotes as well as eukaryotes. Microbes are the exclusive source of PQQ biosynthesis and for biocatalysis of glucose into gluconic acid and 2-ketogluconic acid by gram positive and negative bacteria. This study focus to describe PQQ biography highlighted its applications acts as biocatalyst by enhanced production of NADH from pqqC, involved in several important mechanisms like bacterial energy transduction by m-ATPase, production of biocontrol substances, growth stimulating activities and DNA repair. PQQ acting as anti-neurological, anti-degenerative, anti-melanogenic and anti-cancer agent due to its antioxidant nature by scavenging free radicals. PQQ is modulator of immunity by CD4 cells count and IL-2, sleep maintenance by PGC-1 alpha pathway and inflammation due to ROS. The mineral phosphate solubilization results in plant growth promotional, biocontrol, antifungal and ISR activities. PQQ nanoparticles used for production of Biofuels cells and sulfonated polymers. It acts as a modulator of diverse signaling pathways like STAT, MAPK, JAK, JNK, P13K/Akt, mTOR, EGFR and Raps for cell proliferation, differentiation, apoptosis, Box translocation and metabolic pathways by phosphorylation of ADP and suppression of reactive oxygen species. It protects from oxidative stress by acting as Alpha AA modulator of lysine metabolism, TrxR1 in selenium metabolism, low density lipoprotein in lipid metabolism, ATP production in Energy, Glucose and carbohydrate metabolism. It has been structurally characterized with bioinformatics tools and future perspectives being molecular modeling and docking for analytical drug design.

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“…As a free radical scavenger, PQQ has been reported to increase nerve growth factor (NGF) concentrations in astrocytes and it inhibits melanin production in melanoma cells . In animal models, PQQ has been reported to have a cardioprotective effect, as well as to prevent hepatic alcohol damage (Jia et al, 2015).…”

Section: Pqq Concentrationmentioning

confidence: 99%

“…It has been reported that PQQ is a potent antioxidant (50-100 times more effective than ascorbic acid) (Rucker et al, 2009). It has been also reported that PQQ can function as a protector in cardiac lesions, prevents liver injury by eliminating free radicals, stimulates astrocytes and inhibits the generation of melanocytes in melanoma (Akagawa et al, 2016;Feng et al, 2014;Jia et al, 2015;Murase et al, 1993;Sato and Toriyama, 2009;Tao et al, 2007). In animal models, it has been shown that when PQQ is added to the diet (300 μg/kg body weight), reproduction and neonatal rates in rats and mice were increased (Harris et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Pyrroloquinoline Quinone (PQQ) on Viability of Human Colorectal Adenocarcinoma HT-29 Cell Line

2017

International Journal of Research Studies in Biosciences

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Pyrroloquinoline-Quinone Suppresses Liver Fibrogenesis in Mice

Cited by 31 publications

References 47 publications

Protective effect and mechanism of action of mulberry marc anthocyanins on carbon tetrachloride-induced liver fibrosis in rats

Protective effect and mechanism of action of mulberry marc anthocyanins on carbon tetrachloride-induced liver fibrosis in rats

The Life History of Pyrroloquinoline Quinone (PQQ): A Versatile Molecule with Novel Impacts on Living Systems

The Effect of Pyrroloquinoline Quinone (PQQ) on Viability of Human Colorectal Adenocarcinoma HT-29 Cell Line

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