2014
DOI: 10.1371/journal.pone.0106907
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The Association of Depression and Anxiety with Pain: A Study from NESDA

Abstract: Chronic pain is commonly co-morbid with a depressive or anxiety disorder. Objective of this study is to examine the influence of depression, along with anxiety, on pain-related disability, pain intensity, and pain location in a large sample of adults with and without a depressive and/or anxiety disorder. The study population consisted of 2981 participants with a depressive, anxiety, co-morbid depressive and anxiety disorder, remitted disorder or no current disorder (controls). Severity of depressive and anxiet… Show more

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Cited by 277 publications
(238 citation statements)
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“…In this regard, Clark and Watson (1) indicated to common variance and also specific variance between these two states in order to specify similarities and differences between these two emotional states by presenting tripartite anxiety and depression models. In fact, extensive studies showed anxiety and depression symptoms have high overlapping in young people (2).…”
Section: Introductionmentioning
confidence: 99%
“…In this regard, Clark and Watson (1) indicated to common variance and also specific variance between these two states in order to specify similarities and differences between these two emotional states by presenting tripartite anxiety and depression models. In fact, extensive studies showed anxiety and depression symptoms have high overlapping in young people (2).…”
Section: Introductionmentioning
confidence: 99%
“…The dysregulation in one or both of these neurotransmitters may dampen peripheral pain signals and finally contribute to the frequent presence of MSP symptoms (Marks et al, 2009;Tops et al, 2007). According to De Heer et al (2014), anxiety and burnout facilitates the central modulation of the pain response in the areas of periaqueductal gray, amygdala, and hypothalamus. When deficits occur in these areas, modulation of signals from the body is disturbed, leading to a more severe experience of pain.…”
Section: Conclusion/discussionmentioning
confidence: 99%
“…Есть предположе-ния, что хроническое болевое воздействие вызывает аф-фективные расстройства, приводящие к возникновению тревоги, последняя же в свою очередь участвует в форми-ровании «повышенной чувствительности» и поддержании очагов хронической боли [20]. Также в пользу этой тео-рии говорит тот факт, что при наличии очага хронической боли снижается эффективность лечения тревоги [8,25]. Однако стоит отметить, что существуют исследования, от-рицающие это взаимодействие, утверждая, что некоторые характеристики боли связаны с рецидивом депрессивных, но не тревожных расстройств [10].…”
Section: рис 1 связь возраста дебюта и личностной тревоги (корреляцunclassified