[citation report] Strategies and hurdles using DNA vaccines to fish

Cited by 82 publications

(53 citation statements)

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“…DNA vaccines and their effects against several viral and bacterial diseases in fish have been reported in the last decade (Hølvold et al 2014); however, only a few DNA vaccine strategies have been successful in providing significant protection to fish against S. agalactiae infection. Huang et al (2014) developed an oral DNA vaccine that encoded Sip.…”

Section: Dna Vaccinesmentioning

confidence: 99%

Development of Streptococcus agalactiae vaccines for tilapia

Liu¹,

Zhu²,

Chen³

et al. 2016

Dis. Aquat. Org.

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Vaccination is a widely accepted and effective method to prevent most pathogenic diseases in aquaculture. Various species of tilapia, especially Nile tilapia Oreochromis niloticus, are farmed worldwide because of their high consumer demand. Recently, the tilapia-breeding industry has been hampered by outbreaks of Streptococcus agalactiae infection, which cause high mortality and huge economic losses. Many researchers have attempted to develop effective S. agalactiae vaccines for tilapia. This review provides a summary of the different kinds of S. agalactiae vaccines for tilapia that have been developed recently. Among the various vaccine types, inactivated S. agalactiae vaccines showed superior protection efficiency when compared with live attenuated, recombinant and DNA vaccines. With respect to vaccination method, injecting the vaccine into tilapia provided the most effective immunoprotection. Freund's incomplete adjuvant appeared to be suitable for tilapia vaccines. Other factors, such as immunization duration and number, fish size and challenge dose, also influenced the vaccine efficacy.

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Section: Dna Vaccinesmentioning

confidence: 99%

Development of Streptococcus agalactiae vaccines for tilapia

Liu¹,

Zhu²,

Chen³

et al. 2016

Dis. Aquat. Org.

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“…As traditional oil‐based vaccines show similar efficacies as the bacterial DNA vaccines (Hølvold, Myhr, & Dalmo, ), the need for a bacterial DNA vaccine for fish is not as urgent as antiviral ones. Despite an enormous amount of effort invested in the development of DNA vaccines to protect veterinary animal species and humans against viruses, only a few have reached the market.…”

Section: Introductionmentioning

confidence: 99%

“…More than 20 different virus DNA vaccines have been developed experimentally for prophylactic use in fish targeting viruses such as rhabdoviridae, orthomyxoviridae, togaviridae and nodaviridae. The rhabdoviridae DNA vaccines (e.g., VHSV and IHNV) have shown high levels of efficacies, whereas others have in most instances possessed moderate to low efficacies (Hølvold et al., ; Munang'andu & Evensen, ).…”

Section: Introductionmentioning

confidence: 99%

DNA vaccines for fish: Review and perspectives on correlates of protection

Dalmo¹

2017

Journal of Fish Diseases

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“…In teleosts, PRR-associated sensing of exogenous nucleotides has been shown to lead to antiviral responses via the production of type I IFN and other cytokines. Hence, exogenous nucleic acids (i.e., DNA vaccines, viral RNA, and bacterial DNA) and their analogs can be used as vaccine adjuvants for aquaculture [43]. In this section, therefore, we summarize the nucleotide-sensing PRRs and their cascades in teleosts.…”

Section: The Immune Responses Activated By Nucleic Acid Recognitionmentioning

confidence: 99%