Contemporary workers heavily use communication/information technologies (CIT; eg, e-mails, mobile phones) at work and home. However, little research has investigated the effects of CIT use on work-family interference. Based on boundary theory, the present study focuses on employees' boundary creation around CIT use as a potential means to reduce psychological work-family interference. Hierarchical regression analyses based on the data from 281 office workers supported the mediation models where boundary creation around CIT use mediated the relationships between individual factors and psychological work-family interference. The findings suggested that maintaining impermeable work and home domains by creating more boundaries around CIT use for cross-role enactment can be beneficial for employees' psychological work-family interference.(PsycINFO Database Record (c) 2019 APA, all rights reserved)