[HTML][HTML] Triggering p53 after cytokinesis failure
PT Stukenberg�- The Journal of cell biology, 2004 - ncbi.nlm.nih.gov
The Journal of cell biology, 2004•ncbi.nlm.nih.gov
Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious
mechanism that depends upon p53. What triggers this arrest is unclear. New studies,
including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not
occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed
cytokinesis, making this phenomenon even more puzzling.
mechanism that depends upon p53. What triggers this arrest is unclear. New studies,
including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not
occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed
cytokinesis, making this phenomenon even more puzzling.
Abstract
Cells that fail to divide during cytokinesis often arrest in the next G1 phase by a mysterious mechanism that depends upon p53. What triggers this arrest is unclear. New studies, including a report in this issue (Uetake and Sluder, 2004) suggest that this arrest does not occur because cells are polyploid, are binucleate, have multiple centrosome, or have failed cytokinesis, making this phenomenon even more puzzling.
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