[HTML][HTML] Succinate: a new epigenetic hacker
M Yang, PJ Pollard�- Cancer cell, 2013 - cell.com
M Yang, PJ Pollard
Cancer cell, 2013•cell.comEpigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell,
Letouz� and colleagues describe DNA hypermethylation in paragangliomas harboring
mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which
inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in
epigenetic silencing that affects neuroendocrine differentiation.
Letouz� and colleagues describe DNA hypermethylation in paragangliomas harboring
mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which
inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in
epigenetic silencing that affects neuroendocrine differentiation.
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouz� and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
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