MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer's disease
N Tian, Z Cao, Y Zhang�- Neuroscience bulletin, 2014 - Springer
N Tian, Z Cao, Y Zhang
Neuroscience bulletin, 2014•SpringerMicroRNA alterations have been reported in patients with Alzheimer's disease (AD) and AD
mouse models. We now report that miR-206 is upregulated in the hippocampal tissue,
cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-
206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is
neuroprotective against cell death after various insults, but in embryonic and newborn
APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD�…
mouse models. We now report that miR-206 is upregulated in the hippocampal tissue,
cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-
206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is
neuroprotective against cell death after various insults, but in embryonic and newborn
APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD�…
Abstract
MicroRNA alterations have been reported in patients with Alzheimer’s disease (AD) and AD mouse models. We now report that miR-206 is upregulated in the hippocampal tissue, cerebrospinal fluid, and plasma of embryonic APP/PS1 transgenic mice. The increased miR-206 downregulates the expression of brain-derived neurotrophic factor (BDNF). BDNF is neuroprotective against cell death after various insults, but in embryonic and newborn APP/PS1 mice it is decreased. Thus, a specific microRNA alteration may contribute to AD pathology by downregulating BDNF.
Springer