A reframing of what obesity management means to a person living with obesity is required. Core story Our metaphor begins with education that the prevalence of obesity is best explained by a environment-gene interaction, 3 with 70% of the variability in weight conferred genetically. 18 The majority of the obesity risk genes are expressed in the brain. 19 We each inherit a unique central appetite system that regulates weight by regulating appetite and metabolism. This will challenge many individuals living with obesity because their dominant motivation to engage in obesity management is weight loss; the more the better.[Extracted from the article]

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