The considerable heterogeneity in the number and severity of symptoms observed in autism
spectrum disorders (ASD) has been regarded as an obstacle to any future research. Some
authors believe that clinical heterogeneity results from the complex interplay of the many
genetic and environmental factors that themselves define a condition as multifactorial.
However, it is important to note that neuropathological findings in both idiopathic and
syndromic autism suggests a single pathophysiological mechanism acting during brain�…