Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers
M Slifstein, M Laruelle�- Nuclear medicine and biology, 2001 - Elsevier
The science of quantitative analysis of PET and SPECT neuroreceptor imaging studies has
grown considerably over the past decade. A number of methods have been proposed in
which receptor parameter estimation results from fitting data to a model of the underlying
kinetics of ligand uptake in the brain. These approaches have come to be collectively known
as model-based methods and several have received widespread use. Here, we briefly
review the most frequently used methods and examine their strengths and weaknesses�…
grown considerably over the past decade. A number of methods have been proposed in
which receptor parameter estimation results from fitting data to a model of the underlying
kinetics of ligand uptake in the brain. These approaches have come to be collectively known
as model-based methods and several have received widespread use. Here, we briefly
review the most frequently used methods and examine their strengths and weaknesses�…