Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and
the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and
anti-diabetic functions. Different adiponectin complexes exert tissue-specific biological
functions and activate distinct signaling pathways. In this review, we summarize our current
understanding on the mechanisms regulating adiponectin multimerization. We also describe
the major target tissues in which distinct adiponectin multimers exert their functional roles�…