The goals of this study were to (i) examine the association of social support and strain with psychological well-being and health, (ii) investigate whether these associations depended on relationship-type (partner, family, friend), (iii) examine the buffering effects of support on strain (both within and across relationship-type), and (iv) test the extent to which these associations differed by age and sex. The sample contained 2,348 adults (55% male) aged 25 to 75 years (M = 46.3), who were married or cohabitating. Positive and negative social exchanges were more strongly related to psychological well-being than to health. For both sexes, partner support and strain and family support were predictive of well-being measures; partner strain was also predictive of health problems. However, family strain was predictive of well-being and health outcomes more often for women. Further, while we did find evidence that supportive networks could buffer the detrimental effects of strained interactions, friends and family served a buffering role more often for women than for men.