Testosterone action on skeletal muscle
KL Herbst, S Bhasin�- Current Opinion in Clinical Nutrition &�…, 2004 - journals.lww.com
KL Herbst, S Bhasin
Current Opinion in Clinical Nutrition & Metabolic Care, 2004•journals.lww.comTestosterone induces skeletal muscle hypertrophy by multiple mechanisms, including its
effects in modulating the commitment of pluripotent mesenchymal cells. These changes in
skeletal muscle lead to improved muscle strength and leg power; however, further studies
are needed to determine the effects of testosterone on physical function and health-related
outcomes in sarcopenia associated with aging and chronic illness.
effects in modulating the commitment of pluripotent mesenchymal cells. These changes in
skeletal muscle lead to improved muscle strength and leg power; however, further studies
are needed to determine the effects of testosterone on physical function and health-related
outcomes in sarcopenia associated with aging and chronic illness.
Summary
Testosterone induces skeletal muscle hypertrophy by multiple mechanisms, including its effects in modulating the commitment of pluripotent mesenchymal cells. These changes in skeletal muscle lead to improved muscle strength and leg power; however, further studies are needed to determine the effects of testosterone on physical function and health-related outcomes in sarcopenia associated with aging and chronic illness.
Lippincott Williams & Wilkins