The hormone estrogen is involved in both female and male reproduction, as well as
numerous other biological systems including the neuroendocrine, vascular, skeletal, and
immune systems. Therefore, it is also implicated in many different diseases and conditions
such as infertility, obesity, osteoporosis, endometriosis, and a variety of cancers. Estrogen
works through its two distinct nuclear receptors, estrogen receptor alpha (ERα) and estrogen
receptor beta (ERβ). Various transcriptional regulation mechanisms have been identified as�…