[HTML][HTML] Potential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy
NM Scheltema, XM Kavelaars, K Thorburn, MP Hennus…�- Vaccine, 2018 - Elsevier
NM Scheltema, XM Kavelaars, K Thorburn, MP Hennus, JB van Woensel, CK van der Ent…
Vaccine, 2018•ElsevierBackground Respiratory syncytial virus (RSV) infection is an important cause of infant
mortality. Here, we estimated the potential impact of maternal vaccination against RSV on
life-threatening RSV infection in infants. Methods We developed a mathematical model for
maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV
vaccine currently in phase 3 of clinical development. The model was applied to data from
two cohorts of children younger than 12 months with RSV-related paediatric intensive care�…
mortality. Here, we estimated the potential impact of maternal vaccination against RSV on
life-threatening RSV infection in infants. Methods We developed a mathematical model for
maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV
vaccine currently in phase 3 of clinical development. The model was applied to data from
two cohorts of children younger than 12 months with RSV-related paediatric intensive care�…
Background
Respiratory syncytial virus (RSV) infection is an important cause of infant mortality. Here, we estimated the potential impact of maternal vaccination against RSV on life-threatening RSV infection in infants.
Methods
We developed a mathematical model for maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV vaccine currently in phase 3 of clinical development. The model was applied to data from two cohorts of children younger than 12 months with RSV-related paediatric intensive care unit (PICU) admission in the United Kingdom (n = 370) and the Netherlands (n = 167), and a cohort of 211 children younger than 12 months with RSV-related in-hospital death from 20 countries worldwide.
Results
Our model predicted that, depending on vaccine efficiency, maternal vaccination at 30 weeks’ gestational age could have prevented 62–75% of RSV-related PICU admissions in the United Kingdom and 76–87% in the Netherlands. For the global mortality cohort, the model predicted that maternal vaccination could have prevented 29–48% of RSV-related in-hospital deaths. Preterm children and children with comorbidities were predicted to benefit less than (healthy) term children.
Conclusions
Maternal vaccination against RSV may substantially decrease life-threatening RSV infections in infants.
Elsevier