Intracellular progesterone receptors (PRs) are ligand-inducible transcription factors that
mediate the majority of the effects of progesterone (P) on neuroendocrine functions. During
the past decade, evidence has accumulated which suggest that PRs can also be activated
independently of P, by signals propagated through membrane-bound receptors to the
interior of cells. The activation of PRs by this type of “cross-talk” mechanism has been
implicated in the physiological regulation of several important neuroendocrine processes�…